ID   SPI1_VACCC              Reviewed;         353 AA.
AC   P20531;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   29-SEP-2021, entry version 99.
DE   RecName: Full=Serine proteinase inhibitor 1;
DE            Short=Serp-1;
DE            Short=Serpin-1;
GN   Name=SPI-1; ORFNames=C12L;
OS   Vaccinia virus (strain Copenhagen) (VACV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10249;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2219722; DOI=10.1016/0042-6822(90)90294-2;
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "The complete DNA sequence of vaccinia virus.";
RL   Virology 179:247-266(1990).
RN   [2]
RP   COMPLETE GENOME.
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "Appendix to 'The complete DNA sequence of vaccinia virus'.";
RL   Virology 179:517-563(1990).
CC   -!- FUNCTION: This viral protein may be involved in the regulation of the
CC       complement cascade.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the serpin family. Poxviruses subfamily.
CC       {ECO:0000305}.
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DR   EMBL; M35027; AAA47984.1; -; Genomic_DNA.
DR   PIR; B42503; WMVZ2C.
DR   SMR; P20531; -.
DR   MEROPS; I04.028; -.
DR   Proteomes; UP000008269; Genome.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.39.10; -; 1.
DR   Gene3D; 3.30.497.10; -; 1.
DR   InterPro; IPR015557; Serpin_B1.
DR   InterPro; IPR023795; Serpin_CS.
DR   InterPro; IPR023796; Serpin_dom.
DR   InterPro; IPR000215; Serpin_fam.
DR   InterPro; IPR036186; Serpin_sf.
DR   InterPro; IPR042178; Serpin_sf_1.
DR   InterPro; IPR042185; Serpin_sf_2.
DR   PANTHER; PTHR11461; PTHR11461; 1.
DR   PANTHER; PTHR11461:SF180; PTHR11461:SF180; 1.
DR   Pfam; PF00079; Serpin; 1.
DR   SMART; SM00093; SERPIN; 1.
DR   SUPFAM; SSF56574; SSF56574; 1.
DR   PROSITE; PS00284; SERPIN; 1.
PE   3: Inferred from homology;
KW   Early protein; Host cytoplasm; Protease inhibitor; Reference proteome;
KW   Serine protease inhibitor.
FT   CHAIN           1..353
FT                   /note="Serine proteinase inhibitor 1"
FT                   /id="PRO_0000094135"
FT   SITE            318..319
FT                   /note="Reactive bond"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   353 AA;  40387 MW;  FFD1A9B7008ED0E0 CRC64;
     MDIFKELIVK HPDENVLISP VSILSTLSIL NHGAAGSTAE QLSKYIENMN ENTPDDNNDM
     DVDIPYCATL ATANKIYGSD SIEFHASFLQ KIKDDFQTVN FNNANQTKEL INEWVKTMTN
     GKINSLLTSP LSINTRMTVV SAVHFKAMWK YPFSKHLTYT DKFYISKNIV TSVDMMVGTE
     NNLQYVHINE LFGGFSIIDI PYEGNSSMVI ILPDDIEGIY NIEKNITDEK FKKWCGMLST
     KSIDLYMPKF KVEMTEPYNL VPILENLGLT NIFGYYADFS KMCNETITVE KFLHTTFIDV
     NEEYTEASAV TGVFTINFSM VYRTKVYINH PFMYMIKDTT GRILFIGKYC YPQ