ID   SPI21_RAT               Reviewed;         214 AA.
AC   P09005;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1988, sequence version 1.
DT   25-MAY-2022, entry version 110.
DE   RecName: Full=Serine protease inhibitor 2.1;
DE            Short=SPI-2.1;
DE   Flags: Fragment;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=3493437; DOI=10.1038/326096a0;
RA   Hill R.E., Hastie N.D.;
RT   "Accelerated evolution in the reactive centre regions of serine protease
RT   inhibitors.";
RL   Nature 326:96-99(1987).
CC   -!- SIMILARITY: Belongs to the serpin family. {ECO:0000305}.
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DR   EMBL; X13149; CAA31547.1; -; mRNA.
DR   PIR; A26423; A26423.
DR   AlphaFoldDB; P09005; -.
DR   SMR; P09005; -.
DR   STRING; 10116.ENSRNOP00000013961; -.
DR   MEROPS; I04.049; -.
DR   PaxDb; P09005; -.
DR   PRIDE; P09005; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central.
DR   GO; GO:0010951; P:negative regulation of endopeptidase activity; IBA:GO_Central.
DR   Gene3D; 2.30.39.10; -; 1.
DR   Gene3D; 3.30.497.10; -; 1.
DR   InterPro; IPR023795; Serpin_CS.
DR   InterPro; IPR023796; Serpin_dom.
DR   InterPro; IPR000215; Serpin_fam.
DR   InterPro; IPR036186; Serpin_sf.
DR   InterPro; IPR042178; Serpin_sf_1.
DR   InterPro; IPR042185; Serpin_sf_2.
DR   PANTHER; PTHR11461; PTHR11461; 1.
DR   Pfam; PF00079; Serpin; 1.
DR   SMART; SM00093; SERPIN; 1.
DR   SUPFAM; SSF56574; SSF56574; 1.
DR   PROSITE; PS00284; SERPIN; 1.
PE   2: Evidence at transcript level;
KW   Protease inhibitor; Reference proteome; Serine protease inhibitor.
FT   CHAIN           <1..214
FT                   /note="Serine protease inhibitor 2.1"
FT                   /id="PRO_0000094134"
FT   SITE            180..181
FT                   /note="Reactive bond"
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
SQ   SEQUENCE   214 AA;  24218 MW;  B1F4CEC59425BAAF CRC64;
     LVLVNYLLFK GKWKVPFNPN DTFESEFYLD EKRSVKVPMM KIKEVTTPYV RDEELSCSVL
     ELKYTGNASA LFILPDQGKM QQVESSLQPE TLKKWKDSLI PSIINDLRMP KFSISTDYSL
     EKEVLPELGI KKVFSQQADL SRITGTKDLY VSQVVHKAVL DVAETGTEAT AATGVATVIR
     RQPRTLNFNQ PFMVFITDMD SQSILFVAKI TNPS