ID   SPI2C_MOUSE             Reviewed;         257 AA.
AC   Q6NVE3;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Spindlin-2C;
DE   AltName: Full=Spindlin-like protein 2C;
DE            Short=SPIN-2;
DE            Short=SPIN-2C;
GN   Name=Spin2c; Synonyms=Spin2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May be involved in the regulation of cell cycle progression.
CC       Exhibits H3K4me3-binding activity. {ECO:0000250|UniProtKB:Q99865}.
CC   -!- SUBUNIT: Interacts with C11orf84/SPINDOC.
CC       {ECO:0000250|UniProtKB:Q99865}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9BPZ2}.
CC   -!- SIMILARITY: Belongs to the SPIN/STSY family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC068162; AAH68162.1; -; mRNA.
DR   CCDS; CCDS30485.1; -.
DR   RefSeq; NP_001005370.1; NM_001005370.1.
DR   RefSeq; XP_006528931.1; XM_006528868.3.
DR   RefSeq; XP_006528932.1; XM_006528869.3.
DR   AlphaFoldDB; Q6NVE3; -.
DR   SMR; Q6NVE3; -.
DR   STRING; 10090.ENSMUSP00000059499; -.
DR   iPTMnet; Q6NVE3; -.
DR   PhosphoSitePlus; Q6NVE3; -.
DR   MaxQB; Q6NVE3; -.
DR   PaxDb; Q6NVE3; -.
DR   PRIDE; Q6NVE3; -.
DR   ProteomicsDB; 257320; -.
DR   DNASU; 278240; -.
DR   Ensembl; ENSMUST00000049999; ENSMUSP00000059499; ENSMUSG00000046550.
DR   GeneID; 278240; -.
DR   KEGG; mmu:278240; -.
DR   UCSC; uc009urb.1; mouse.
DR   CTD; 278240; -.
DR   MGI; MGI:3605548; Spin2c.
DR   VEuPathDB; HostDB:ENSMUSG00000046550; -.
DR   eggNOG; ENOG502QRYD; Eukaryota.
DR   GeneTree; ENSGT00950000182925; -.
DR   HOGENOM; CLU_068595_0_0_1; -.
DR   InParanoid; Q6NVE3; -.
DR   OMA; DVHLANT; -.
DR   OrthoDB; 1027563at2759; -.
DR   PhylomeDB; Q6NVE3; -.
DR   TreeFam; TF332665; -.
DR   BioGRID-ORCS; 278240; 2 hits in 71 CRISPR screens.
DR   PRO; PR:Q6NVE3; -.
DR   Proteomes; UP000000589; Chromosome X.
DR   RNAct; Q6NVE3; protein.
DR   Bgee; ENSMUSG00000046550; Expressed in primitive streak and 188 other tissues.
DR   ExpressionAtlas; Q6NVE3; baseline and differential.
DR   Genevisible; Q6NVE3; MM.
DR   GO; GO:0005829; C:cytosol; ISO:MGI.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0035064; F:methylated histone binding; ISS:UniProtKB.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0007276; P:gamete generation; IEA:InterPro.
DR   GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 2.80.10.70; -; 1.
DR   InterPro; IPR029564; SPIN-2.
DR   InterPro; IPR003671; SPIN/Ssty.
DR   InterPro; IPR042567; SPIN/Ssty_sf.
DR   PANTHER; PTHR10405; PTHR10405; 1.
DR   PANTHER; PTHR10405:SF32; PTHR10405:SF32; 1.
DR   Pfam; PF02513; Spin-Ssty; 3.
PE   2: Evidence at transcript level;
KW   Cell cycle; Nucleus; Reference proteome.
FT   CHAIN           1..257
FT                   /note="Spindlin-2C"
FT                   /id="PRO_0000259590"
FT   REGION          1..47
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          48..97
FT                   /note="Tudor-like domain 1"
FT                   /evidence="ECO:0000255"
FT   REGION          127..176
FT                   /note="Tudor-like domain 2"
FT                   /evidence="ECO:0000255"
FT   REGION          136
FT                   /note="Histone H3K4me3 and H3R8me2a binding"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y657"
FT   REGION          208..253
FT                   /note="Tudor-like domain 3"
FT                   /evidence="ECO:0000255"
FT   REGION          244..246
FT                   /note="Histone H3K4me3 and H3R8me2a binding"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y657"
FT   COMPBIAS        24..42
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   SITE            167
FT                   /note="Histone H3K4me3 and H3R8me2a binding"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y657"
FT   SITE            174
FT                   /note="Histone H3K4me3 and H3R8me2a binding"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y657"
FT   SITE            178
FT                   /note="Histone H3K4me3 and H3R8me2a binding"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y657"
SQ   SEQUENCE   257 AA;  29207 MW;  32F52B2A262A73F3 CRC64;
     MKTPHKKGAA KEQMGEGVGH HIGSTTIKKK KASQKRQRSR SSSRRSIVGC RISHGWKEGD
     EPITQWKGTV LDQVPINPSL YLVKYDGIDC VYGLELHRDE RILKLKILPD KVSFSGVSDV
     RLANTIIGKA VEHMFEGEHG SKDEWRGMVL AQAPIMNAWF YITYERDPVL YMYQLLDDYK
     EGDLRIMPES SASPPADREP EGVVDGLIGK HVEYTKEDGS KRTGKVIHQV KAKPSVYFIK
     FDDDFHIYVY DLVKKNS