SPI2_HUMAN
ID SPI2_HUMAN Reviewed; 405 AA.
AC O75830;
DT 23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 181.
DE RecName: Full=Serpin I2;
DE AltName: Full=Myoepithelium-derived serine protease inhibitor;
DE AltName: Full=Pancpin;
DE AltName: Full=Pancreas-specific protein TSA2004;
DE AltName: Full=Peptidase inhibitor 14;
DE Short=PI-14;
DE Flags: Precursor;
GN Name=SERPINI2; Synonyms=MEPI, PI14;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=9624529;
RX DOI=10.1002/(sici)1098-2264(199807)22:3<179::aid-gcc3>3.0.co;2-t;
RA Ozaki K., Nagata M., Suzuki M., Fujiwara T., Miyoshi Y., Ishikawa O.,
RA Ohigashi H., Imaoka S., Takahashi E., Nakamura Y.;
RT "Isolation and characterization of a novel human pancreas-specific gene,
RT pancpin, that is down-regulated in pancreatic cancer cells.";
RL Genes Chromosomes Cancer 22:179-185(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10097100; DOI=10.1073/pnas.96.7.3700;
RA Xiao G., Liu Y.E., Gentz R., Sang Q.A., Ni J., Goldberg I.D., Shi Y.E.;
RT "Suppression of breast cancer growth and metastasis by a serpin
RT myoepithelium-derived serine proteinase inhibitor expressed in the mammary
RT myoepithelial cells.";
RL Proc. Natl. Acad. Sci. U.S.A. 96:3700-3705(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pancreas, and Spleen;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC O75830; P37235: HPCAL1; NbExp=3; IntAct=EBI-750144, EBI-749311;
CC O75830; O43765: SGTA; NbExp=3; IntAct=EBI-750144, EBI-347996;
CC O75830; Q96EQ0: SGTB; NbExp=4; IntAct=EBI-750144, EBI-744081;
CC O75830; Q9UMX0: UBQLN1; NbExp=10; IntAct=EBI-750144, EBI-741480;
CC O75830; Q9UMX0-2: UBQLN1; NbExp=3; IntAct=EBI-750144, EBI-10173939;
CC O75830; Q9UHD9: UBQLN2; NbExp=3; IntAct=EBI-750144, EBI-947187;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in pancreas and adipose tissues.
CC {ECO:0000269|PubMed:9624529}.
CC -!- SIMILARITY: Belongs to the serpin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH27859.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB006423; BAA33766.1; -; mRNA.
DR EMBL; AF130470; AAD34723.1; -; mRNA.
DR EMBL; BC027859; AAH27859.2; ALT_INIT; mRNA.
DR CCDS; CCDS3200.1; -.
DR CCDS; CCDS75047.1; -.
DR RefSeq; NP_001012303.1; NM_001012303.2.
DR RefSeq; NP_006208.1; NM_006217.4.
DR AlphaFoldDB; O75830; -.
DR SMR; O75830; -.
DR BioGRID; 111294; 15.
DR IntAct; O75830; 10.
DR MINT; O75830; -.
DR STRING; 9606.ENSP00000481699; -.
DR MEROPS; I04.026; -.
DR GlyGen; O75830; 3 sites.
DR iPTMnet; O75830; -.
DR PhosphoSitePlus; O75830; -.
DR BioMuta; SERPINI2; -.
DR EPD; O75830; -.
DR jPOST; O75830; -.
DR MassIVE; O75830; -.
DR PaxDb; O75830; -.
DR PeptideAtlas; O75830; -.
DR PRIDE; O75830; -.
DR ProteomicsDB; 50219; -.
DR Antibodypedia; 33688; 270 antibodies from 34 providers.
DR DNASU; 5276; -.
DR Ensembl; ENST00000264677.8; ENSP00000264677.4; ENSG00000114204.15.
DR Ensembl; ENST00000461846.5; ENSP00000417692.1; ENSG00000114204.15.
DR Ensembl; ENST00000471111.5; ENSP00000419407.1; ENSG00000114204.15.
DR Ensembl; ENST00000476257.5; ENSP00000420621.1; ENSG00000114204.15.
DR GeneID; 5276; -.
DR KEGG; hsa:5276; -.
DR MANE-Select; ENST00000264677.9; ENSP00000264677.4; NM_006217.6; NP_006208.1.
DR UCSC; uc003fer.3; human.
DR CTD; 5276; -.
DR DisGeNET; 5276; -.
DR GeneCards; SERPINI2; -.
DR HGNC; HGNC:8945; SERPINI2.
DR HPA; ENSG00000114204; Tissue enriched (pancreas).
DR MIM; 605587; gene.
DR neXtProt; NX_O75830; -.
DR OpenTargets; ENSG00000114204; -.
DR PharmGKB; PA35513; -.
DR VEuPathDB; HostDB:ENSG00000114204; -.
DR eggNOG; KOG2392; Eukaryota.
DR GeneTree; ENSGT00940000161641; -.
DR HOGENOM; CLU_023330_0_4_1; -.
DR InParanoid; O75830; -.
DR OMA; RQTLKFQ; -.
DR OrthoDB; 1124079at2759; -.
DR PhylomeDB; O75830; -.
DR TreeFam; TF343094; -.
DR PathwayCommons; O75830; -.
DR SignaLink; O75830; -.
DR BioGRID-ORCS; 5276; 8 hits in 1064 CRISPR screens.
DR ChiTaRS; SERPINI2; human.
DR GeneWiki; SERPINI2; -.
DR GenomeRNAi; 5276; -.
DR Pharos; O75830; Tbio.
DR PRO; PR:O75830; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; O75830; protein.
DR Bgee; ENSG00000114204; Expressed in body of pancreas and 109 other tissues.
DR ExpressionAtlas; O75830; baseline and differential.
DR Genevisible; O75830; HS.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central.
DR GO; GO:0010951; P:negative regulation of endopeptidase activity; IBA:GO_Central.
DR GO; GO:0030155; P:regulation of cell adhesion; IEA:Ensembl.
DR Gene3D; 2.30.39.10; -; 1.
DR Gene3D; 3.30.497.10; -; 1.
DR InterPro; IPR023795; Serpin_CS.
DR InterPro; IPR023796; Serpin_dom.
DR InterPro; IPR000215; Serpin_fam.
DR InterPro; IPR036186; Serpin_sf.
DR InterPro; IPR042178; Serpin_sf_1.
DR InterPro; IPR042185; Serpin_sf_2.
DR PANTHER; PTHR11461; PTHR11461; 1.
DR Pfam; PF00079; Serpin; 1.
DR SMART; SM00093; SERPIN; 1.
DR SUPFAM; SSF56574; SSF56574; 1.
DR PROSITE; PS00284; SERPIN; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Protease inhibitor; Reference proteome; Secreted;
KW Serine protease inhibitor; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..405
FT /note="Serpin I2"
FT /id="PRO_0000032525"
FT SITE 357..358
FT /note="Reactive bond"
FT /evidence="ECO:0000250"
FT CARBOHYD 202
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 207
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 306
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 6
FT /note="L -> V (in dbSNP:rs17246389)"
FT /id="VAR_051957"
FT VARIANT 148
FT /note="E -> G (in dbSNP:rs9841174)"
FT /id="VAR_024357"
SQ SEQUENCE 405 AA; 46145 MW; 5BA18C60E4FDE9A4 CRC64;
MDTIFLWSLL LLFFGSQASR CSAQKNTEFA VDLYQEVSLS HKDNIIFSPL GITLVLEMVQ
LGAKGKAQQQ IRQTLKQQET SAGEEFFVLK SFFSAISEKK QEFTFNLANA LYLQEGFTVK
EQYLHGNKEF FQSAIKLVDF QDAKACAEMI STWVERKTDG KIKDMFSGEE FGPLTRLVLV
NAIYFKGDWK QKFRKEDTQL INFTKKNGST VKIPMMKALL RTKYGYFSES SLNYQVLELS
YKGDEFSLII ILPAEGMDIE EVEKLITAQQ ILKWLSEMQE EEVEISLPRF KVEQKVDFKD
VLYSLNITEI FSGGCDLSGI TDSSEVYVSQ VTQKVFFEIN EDGSEAATST GIHIPVIMSL
AQSQFIANHP FLFIMKHNPT ESILFMGRVT NPDTQEIKGR DLDSL
