ID   SPI2_MYXVL              Reviewed;         333 AA.
AC   P68565; Q9WPF7;
DT   07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   07-APR-2021, entry version 65.
DE   RecName: Full=Serine proteinase inhibitor 2;
DE            Short=Serp-2;
DE            Short=Serpin-2;
GN   Name=SERP2; Synonyms=SPI-2; OrderedLocusNames=m151R;
OS   Myxoma virus (strain Lausanne) (MYXV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Leporipoxvirus.
OX   NCBI_TaxID=31530;
OH   NCBI_TaxID=9986; Oryctolagus cuniculus (Rabbit).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND CHARACTERIZATION.
RX   PubMed=10400732; DOI=10.1128/jvi.73.8.6394-6404.1999;
RA   Turner P.C., Sancho M.C., Thoennes S.R., Caputo A., Bleackley R.C.,
RA   Moyer R.W.;
RT   "Myxoma virus Serp2 is a weak inhibitor of granzyme B and interleukin-1-
RT   beta-converting enzyme in vitro and unlike CrmA cannot block apoptosis in
RT   cowpox virus-infected cells.";
RL   J. Virol. 73:6394-6404(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10562494; DOI=10.1006/viro.1999.0001;
RA   Cameron C., Hota-Mitchell S., Chen L., Barrett J.W., Cao J.-X.,
RA   Macaulay C., Willer D.O., Evans D.H., McFadden G.;
RT   "The complete DNA sequence of myxoma virus.";
RL   Virology 264:298-318(1999).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Best S.M., Collins S.V., Kerr P.J.;
RT   "Coevolution of host and virus: cellular localization of virus in myxoma
RT   virus infection of resistant and susceptible European rabbits.";
RL   Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Weak inhibitor of the interleukin-1-beta converting enzyme
CC       (ICE) and of granzyme B. Does not form a stable complex with ICE, but
CC       can for a stable complex with granzyme B.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the serpin family. Poxviruses subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AF141941; AAD45255.1; -; Genomic_DNA.
DR   EMBL; AF170726; AAF15038.1; -; Genomic_DNA.
DR   EMBL; AF244936; AAF72165.1; -; Genomic_DNA.
DR   EMBL; AF244937; AAF72166.1; -; Genomic_DNA.
DR   RefSeq; NP_051864.1; NC_001132.2.
DR   SMR; P68565; -.
DR   MEROPS; I04.077; -.
DR   PRIDE; P68565; -.
DR   GeneID; 932102; -.
DR   KEGG; vg:932102; -.
DR   Proteomes; UP000000867; Genome.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0039650; P:suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.39.10; -; 1.
DR   Gene3D; 3.30.497.10; -; 1.
DR   InterPro; IPR023795; Serpin_CS.
DR   InterPro; IPR023796; Serpin_dom.
DR   InterPro; IPR000215; Serpin_fam.
DR   InterPro; IPR036186; Serpin_sf.
DR   InterPro; IPR042178; Serpin_sf_1.
DR   InterPro; IPR042185; Serpin_sf_2.
DR   PANTHER; PTHR11461; PTHR11461; 1.
DR   Pfam; PF00079; Serpin; 1.
DR   SMART; SM00093; SERPIN; 1.
DR   SUPFAM; SSF56574; SSF56574; 1.
DR   PROSITE; PS00284; SERPIN; 1.
PE   1: Evidence at protein level;
KW   Host cytoplasm; Host-virus interaction;
KW   Inhibition of host caspases by virus;
KW   Modulation of host cell apoptosis by virus; Protease inhibitor;
KW   Reference proteome; Serine protease inhibitor.
FT   CHAIN           1..333
FT                   /note="Serine proteinase inhibitor 2"
FT                   /id="PRO_0000094147"
FT   SITE            294..295
FT                   /note="Reactive bond"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   333 AA;  38046 MW;  183C779B5B083471 CRC64;
     MELFKHFLQS TASDVFVSPV SISAVLAVLL EGAKGRTAAQ LRLALEPRYS HLDKVTVASR
     VYGDWRLDIK PKFMQAVRDR FELVNFNHSP EKIKDDINRW VAARTNNKIL NAVNSISPDT
     KLLIVAAIYF EVAWRNQFVP DFTIEGEFWV TKDVSKTVRM MTLSDDFRFV DVRNEGIKMI
     ELPYEYGYSM LVIIPDDLEQ VERHLSLMKV ISWLKMSTLR YVHLSFPKFK METSYTLNEA
     LATSGVTDIF AHPNFEDMTD DKNVAVSDIF HKAYIEVTEF GTTAASCTYG CVTDFGGTMD
     PVVLKVNKPF IFIIKHDDTF SLLFLGRVTS PNY