ID   SPI2_RABPU              Reviewed;         345 AA.
AC   P42926; Q6RZB6;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   10-FEB-2021, entry version 80.
DE   RecName: Full=Serine proteinase inhibitor 2;
DE            Short=Serp-2;
DE            Short=Serpin-2;
GN   Name=SPI-2; OrderedLocusNames=RPXV175;
OS   Rabbitpox virus (strain Utrecht) (RPV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=45417;
OH   NCBI_TaxID=9986; Oryctolagus cuniculus (Rabbit).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8009842; DOI=10.1006/viro.1994.1347;
RA   Ali A.N., Turner P.C., Brooks M.A., Moyer R.W.;
RT   "The SPI-1 gene of rabbitpox virus determines host range and is required
RT   for hemorrhagic pock formation.";
RL   Virology 202:305-314(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16227218; DOI=10.1099/vir.0.81331-0;
RA   Li G., Chen N., Roper R.L., Feng Z., Hunter A.L., Danila M.,
RA   Lefkowitz E.J., Buller R.M.L., Upton C.;
RT   "Complete coding sequences of the rabbitpox virus genome.";
RL   J. Gen. Virol. 86:2969-2977(2005).
CC   -!- FUNCTION: May be involved in the regulation of the complement cascade.
CC       Involved in red pock formation.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the serpin family. Poxviruses subfamily.
CC       {ECO:0000305}.
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DR   EMBL; U07763; AAA19158.1; -; Genomic_DNA.
DR   EMBL; AY484669; AAS49888.1; -; Genomic_DNA.
DR   SMR; P42926; -.
DR   MEROPS; I04.028; -.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0039650; P:suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.39.10; -; 1.
DR   Gene3D; 3.30.497.10; -; 1.
DR   InterPro; IPR015557; Serpin_B1.
DR   InterPro; IPR023795; Serpin_CS.
DR   InterPro; IPR023796; Serpin_dom.
DR   InterPro; IPR000215; Serpin_fam.
DR   InterPro; IPR036186; Serpin_sf.
DR   InterPro; IPR042178; Serpin_sf_1.
DR   InterPro; IPR042185; Serpin_sf_2.
DR   PANTHER; PTHR11461; PTHR11461; 1.
DR   PANTHER; PTHR11461:SF180; PTHR11461:SF180; 1.
DR   Pfam; PF00079; Serpin; 1.
DR   SMART; SM00093; SERPIN; 1.
DR   SUPFAM; SSF56574; SSF56574; 1.
DR   PROSITE; PS00284; SERPIN; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host-virus interaction;
KW   Inhibition of host caspases by virus;
KW   Modulation of host cell apoptosis by virus; Protease inhibitor;
KW   Serine protease inhibitor.
FT   CHAIN           1..345
FT                   /note="Serine proteinase inhibitor 2"
FT                   /id="PRO_0000094149"
FT   SITE            306..307
FT                   /note="Reactive bond"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   345 AA;  38548 MW;  52AD4B3E3F671913 CRC64;
     MDIFREIASS MKGENVFISP ASISSVLTIL YYGANGSTAE QLSKYVEKEE NMDKVSAQNI
     SFKSINKVYG RYSAVFKDSF LRKIGDKFQT VDFTDCRTID AINKCVDIFT EGKINPLLDE
     QLSPDTCLLA ISAVYFKAKW LTPFEKEFTS DYPFYVSPTE MVDVSMMSMY GKAFNHASVK
     ESFGNFSIIE LPYVGDTSMM VILPDKIDGL ESIEQNLTDT NFKKWCNSLE ATFIDVHIPK
     FKVTGSYNLV DTLVKSGLTE VFGSTGDYSN MCNLDVSVDA MIHKTYIDVN EEYTEAAAAT
     SVLVADCAST VTNEFCADHP FIYVIRHVDG KILFVGRYCS PTTNC