ID   SPI3_LONON              Reviewed;         383 AA.
AC   Q5MGH0; Q5MGG9;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 41.
DE   RecName: Full=Serine protease inhibitor 3/4;
DE            Short=Serpin-3/4;
DE   Flags: Precursor; Fragment;
OS   Lonomia obliqua (Moth).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Saturniidae; Hemileucinae; Lonomia.
OX   NCBI_TaxID=304329;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAV91430.1}
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Tegument {ECO:0000312|EMBL:AAV91430.1};
RX   PubMed=16023793; DOI=10.1016/j.gene.2005.05.002;
RA   Veiga A.B.G., Ribeiro J.M.C., Guimaraes J.A., Francischetti I.M.B.;
RT   "A catalog for the transcripts from the venomous structures of the
RT   caterpillar Lonomia obliqua: identification of the proteins potentially
RT   involved in the coagulation disorder and hemorrhagic syndrome.";
RL   Gene 355:11-27(2005).
RN   [2] {ECO:0000305}
RP   PROTEIN SEQUENCE OF 329-341.
RC   TISSUE=Larval bristle {ECO:0000269|PubMed:18342903};
RX   PubMed=18342903; DOI=10.1016/j.toxicon.2008.01.013;
RA   Ricci-Silva M.E., Valente R.H., Leon I.R., Tambourgi D.V., Ramos O.H.P.,
RA   Perales J., Chudzinski-Tavassi A.M.;
RT   "Immunochemical and proteomic technologies as tools for unravelling toxins
RT   involved in envenoming by accidental contact with Lonomia obliqua
RT   caterpillars.";
RL   Toxicon 51:1017-1028(2008).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1 {ECO:0000269|PubMed:16023793};
CC         IsoId=Q5MGH0-1; Sequence=Displayed;
CC       Name=2 {ECO:0000269|PubMed:16023793};
CC         IsoId=Q5MGH0-2; Sequence=VSP_052493, VSP_052494;
CC   -!- SIMILARITY: Belongs to the serpin family. {ECO:0000255}.
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DR   EMBL; AY829816; AAV91430.1; -; mRNA.
DR   EMBL; AY829817; AAV91431.1; -; mRNA.
DR   AlphaFoldDB; Q5MGH0; -.
DR   SMR; Q5MGH0; -.
DR   MEROPS; I04.031; -.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.39.10; -; 1.
DR   Gene3D; 3.30.497.10; -; 1.
DR   InterPro; IPR023796; Serpin_dom.
DR   InterPro; IPR000215; Serpin_fam.
DR   InterPro; IPR036186; Serpin_sf.
DR   InterPro; IPR042178; Serpin_sf_1.
DR   InterPro; IPR042185; Serpin_sf_2.
DR   PANTHER; PTHR11461; PTHR11461; 1.
DR   Pfam; PF00079; Serpin; 1.
DR   SMART; SM00093; SERPIN; 1.
DR   SUPFAM; SSF56574; SSF56574; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Direct protein sequencing; Protease inhibitor;
KW   Serine protease inhibitor; Signal.
FT   SIGNAL          <1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..383
FT                   /note="Serine protease inhibitor 3/4"
FT                   /id="PRO_0000296379"
FT   SITE            363..364
FT                   /note="Reactive bond"
FT                   /evidence="ECO:0000250|UniProtKB:P80034"
FT   VAR_SEQ         7..82
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16023793"
FT                   /id="VSP_052493"
FT   VAR_SEQ         358..383
FT                   /note="EFAANFSSFTRDRNYLIVKQTVRVFP -> AFGISYLSAVITQPRSFVADHP
FT                   FIFMLKEGRKILFFGTMMS (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16023793"
FT                   /id="VSP_052494"
FT   CONFLICT        279
FT                   /note="V -> A (in Ref. 1; AAV91431)"
FT                   /evidence="ECO:0000305"
FT   NON_TER         1
FT                   /evidence="ECO:0000312|EMBL:AAV91430.1"
SQ   SEQUENCE   383 AA;  43194 MW;  F3AD6E92424371C8 CRC64;
     RPLRPGKILI CIFALAALTT ATETDLQRIL RDGNDQFTAK MLPEIVKENP NKNIVFSAFS
     VMSPLAQLAI ASAGESRDEL FSAIGFPNEN VTKAVFTDLN RELKSVKGVT LKIANKIYIA
     NGFELNDQFA VVSKDVFNSE VQKLDFAQNK VAAKTINTWV EDHTNNRIKD LVDPNSLDDY
     TRAVLVNALY FKGSWKNKFD KESTIDRPFH VDNTKTIQVP TMHRSGQYSY GESRELNAKI
     IEMPYEGDET SLVIVLPNTV DGIHNLLEKL KDPKVLSRVE KDMHEIDVDV YVPKFKIETT
     TDLKKVLQNM NIKKLFNGSE ARLDYLLKKS DALYVSEAVQ KAFIEVNEEG AEAAAANEFA
     ANFSSFTRDR NYLIVKQTVR VFP