ID   SPICE_BOVIN             Reviewed;         860 AA.
AC   Q2T9X8;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Spindle and centriole-associated protein 1;
DE   AltName: Full=Coiled-coil domain-containing protein 52;
GN   Name=SPICE1; Synonyms=CCDC52;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulator required for centriole duplication. for proper
CC       bipolar spindle formation and chromosome congression in mitosis (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with CEP120. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome, centriole {ECO:0000250}. Cytoplasm, cytoskeleton,
CC       spindle {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC111217; AAI11218.1; -; mRNA.
DR   RefSeq; NP_001033206.1; NM_001038117.2.
DR   AlphaFoldDB; Q2T9X8; -.
DR   SMR; Q2T9X8; -.
DR   STRING; 9913.ENSBTAP00000049245; -.
DR   PaxDb; Q2T9X8; -.
DR   PRIDE; Q2T9X8; -.
DR   GeneID; 515350; -.
DR   KEGG; bta:515350; -.
DR   CTD; 152185; -.
DR   eggNOG; ENOG502QQ0H; Eukaryota.
DR   InParanoid; Q2T9X8; -.
DR   OrthoDB; 351032at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005814; C:centriole; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005819; C:spindle; ISS:UniProtKB.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0090307; P:mitotic spindle assembly; ISS:UniProtKB.
DR   GO; GO:0046599; P:regulation of centriole replication; ISS:UniProtKB.
DR   InterPro; IPR031387; SPICE1.
DR   PANTHER; PTHR31167; PTHR31167; 1.
DR   Pfam; PF15678; SPICE; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Coiled coil; Cytoplasm; Cytoskeleton; Mitosis;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..860
FT                   /note="Spindle and centriole-associated protein 1"
FT                   /id="PRO_0000282412"
FT   REGION          160..200
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          232..254
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          293..330
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          790..860
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          383..437
FT                   /evidence="ECO:0000255"
FT   COILED          729..755
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        167..181
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        182..200
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        309..330
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        796..836
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         236
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8N0Z3"
FT   MOD_RES         646
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8N0Z3"
FT   MOD_RES         765
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8N0Z3"
FT   MOD_RES         769
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8N0Z3"
FT   MOD_RES         824
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8C804"
SQ   SEQUENCE   860 AA;  95713 MW;  7AD87FE7C8D6A9FD CRC64;
     MSFVRVNRYG PRGGGRKTLK VKKKTSVKQE WDNTVTDLTV HRATPEDLIR RHEIHKSKNR
     ALVHWELQEK ALKRRWKKQK PEISNLEKRR LSIMKEILSD QYQLQDVLEK SDHLMATAKG
     LFVDFPRRRT GFPNVTMAPE SSQSPTVVSK DPVTQAIRSE SVIEPQALNE VDDDEQEGTV
     NSQSEESENE LDNSLSSQSN ANAGTFLHQI KEENSELINK LWTDIQQKVA TQSQMTASSG
     TPSSASPSGE QKAALNATNA VKRIHTRLQP EESTETLDSS YVVGQVLNSR KQKQLLNKVK
     RKPDSRAPSK QKSSMLSAST ASTDLPSSSN PSLDVLKHMI HEVEHEIEEY ERWTGREVQG
     LQNSQGLTGF TLSLVSSLCR LVRYLKESEL QLRKEVETRQ RLEEALGDHR ELIDALTAEV
     LFLREENTAT QARLQQYMIT TDEQLISLTH AIKNCPVISN KESQALERGA TSQRHIDNPE
     DPAVNASVSM PLMFRGEDVV EFPQEDLPVK LSQVPNPPES GDLASSLPGH IFEPAVLLTP
     PRQKSNSEFS PLQDVLRRTV QTRPAPRIPP TVEIIEKEQN WEKKTLPVGA DIQNSSDESH
     LFTQRWRASH MGEDSQSKTQ APFVSLSQPL CSSQSSMQQS RNPTLSEEPL VLGDGQQLRT
     NETLIQRKDI MARIAELTLQ NSDIRAHLNN IIGPGGEQGD GLREFNRQET SHASDTMATF
     PAVQPLTPSS MEERIAELNR QSMEARGKLL QLIEQQKLLG LNPSSPPVSP VQSPLRAWAE
     GGKRTIEVSI PGAEAPESSK CSTDSPTSGL NSRRSSGAAS NSCSPLNATS GSGRLTPLNP
     RAKIEKQNEE GWFALSTHVS