ID   SPICE_XENLA             Reviewed;         793 AA.
AC   Q6DF94;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 48.
DE   RecName: Full=Spindle and centriole-associated protein 1;
DE   AltName: Full=Coiled-coil domain-containing protein 52;
GN   Name=spice1; Synonyms=ccdc52;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulator required for centriole duplication. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome, centriole {ECO:0000250}. Cytoplasm, cytoskeleton,
CC       spindle {ECO:0000250}.
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DR   EMBL; BC076847; AAH76847.1; -; mRNA.
DR   RefSeq; NP_001086591.1; NM_001093122.1.
DR   AlphaFoldDB; Q6DF94; -.
DR   SMR; Q6DF94; -.
DR   DNASU; 446426; -.
DR   GeneID; 446426; -.
DR   KEGG; xla:446426; -.
DR   CTD; 446426; -.
DR   Xenbase; XB-GENE-993585; spice1.L.
DR   OrthoDB; 351032at2759; -.
DR   Proteomes; UP000186698; Chromosome 2L.
DR   Bgee; 446426; Expressed in egg cell and 18 other tissues.
DR   GO; GO:0005814; C:centriole; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005819; C:spindle; ISS:UniProtKB.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0090307; P:mitotic spindle assembly; IEA:InterPro.
DR   GO; GO:0046599; P:regulation of centriole replication; ISS:UniProtKB.
DR   InterPro; IPR031387; SPICE1.
DR   PANTHER; PTHR31167; PTHR31167; 1.
DR   Pfam; PF15678; SPICE; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Coiled coil; Cytoplasm; Cytoskeleton; Mitosis;
KW   Reference proteome.
FT   CHAIN           1..793
FT                   /note="Spindle and centriole-associated protein 1"
FT                   /id="PRO_0000282417"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          519..542
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          718..783
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          312..405
FT                   /evidence="ECO:0000255"
FT   COILED          622..712
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..17
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        718..777
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   793 AA;  87704 MW;  F3494361F6CAA33F CRC64;
     MSYLRASRTS SNLSLAKKPS KTRKKLQARK EWDSSVNDLT VFRATNEELE HRREIHRSKN
     QWLARWELQN KANYKQSEKE NSTQFENSRL ALMKEILSDQ YLMNDVLERS DRALAVVKDL
     FGDAPRRHTG FPNVTMAPSC DLETSRAPIV RKKDPPTQLS ILSESVMDSQ AINEVDKSLS
     RSEYSDSEAE VSISIQPNMK AERVQQLLTG EGPKSEAFIT PHKSEGDPSQ TQCALNATTA
     VNRVKVRRTE EESPKPEESD SIIGRVLNPH GKANKRISLK GKKKRTTNQS QTKDFSTFKA
     SERDLTTSNQ SSLGLLNSMI MEVEQDLAEY ERQTGREVLS APPAHGLTGF TLSLVSSLKR
     VVSYLKESDL LLQREVRERQ NLQGELVEQR LMLDALTAEI LSLKEGGNIH ENHSQTKQCP
     EVDGDKLTSI TQEAKTFPGL NGETCRTSAD CGLSKVNQFM DSQDVQDTDE KHSRLGVSKD
     EFGARLYPQG RPAEEPRLAS ALPSHVFQQA VLLSPPRQKT VGNLSSHSAV PKRAANRLPS
     PPADLMTAPV EIEWPESKLF QRSINYKNTA ALIERGTMVP GQENSKHVYS SAQGSERVNQ
     HPTESTKEVQ GLEIGESQIN PLQNEDLVSQ MQQLALQNAA LKAQLEQIHF SPEGNAPEEA
     AAEQLHNPEP ATDTPARAAL VPVSLEMRIA ELNRQSAEAR NKLLKLIEQQ KQSIVVSPTL
     SPITPQGRRT GSSLDTTPLS SCSTSGRRSS GASNKSESIS TSVGSLRSAS TGRRSQAAND
     RGEGWFALSA HIS