ID   SPIC_BOVIN              Reviewed;         248 AA.
AC   Q1RML4;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Transcription factor Spi-C;
GN   Name=SPIC;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thymus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Controls the development of red pulp macrophages required for
CC       red blood cells recycling and iron homeostasis. Transcription factor
CC       that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3')
CC       that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene
CC       expression (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Binds DNA as a monomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ETS family. {ECO:0000305}.
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DR   EMBL; BC114834; AAI14835.1; -; mRNA.
DR   RefSeq; NP_001069889.1; NM_001076421.1.
DR   RefSeq; XP_005206760.1; XM_005206703.3.
DR   AlphaFoldDB; Q1RML4; -.
DR   SMR; Q1RML4; -.
DR   STRING; 9913.ENSBTAP00000013069; -.
DR   PaxDb; Q1RML4; -.
DR   PRIDE; Q1RML4; -.
DR   Ensembl; ENSBTAT00000070386; ENSBTAP00000068421; ENSBTAG00000009904.
DR   GeneID; 616438; -.
DR   KEGG; bta:616438; -.
DR   CTD; 121599; -.
DR   VEuPathDB; HostDB:ENSBTAG00000009904; -.
DR   VGNC; VGNC:35214; SPIC.
DR   eggNOG; KOG3805; Eukaryota.
DR   GeneTree; ENSGT00940000155067; -.
DR   HOGENOM; CLU_098156_0_0_1; -.
DR   InParanoid; Q1RML4; -.
DR   OMA; EIFYSPY; -.
DR   OrthoDB; 1272250at2759; -.
DR   Proteomes; UP000009136; Chromosome 5.
DR   Bgee; ENSBTAG00000009904; Expressed in spleen and 53 other tissues.
DR   ExpressionAtlas; Q1RML4; baseline.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR046328; ETS_fam.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11849; PTHR11849; 1.
DR   Pfam; PF00178; Ets; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..248
FT                   /note="Transcription factor Spi-C"
FT                   /id="PRO_0000287136"
FT   DNA_BIND        111..194
FT                   /note="ETS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00237"
SQ   SEQUENCE   248 AA;  29112 MW;  526CF8A1DD02EDC1 CRC64;
     MACAEQDKLG QAFEDAFEVL RQHSTGDFQY SSDYKNYLAF INHRSHIRGN SNSYGVQPAE
     EPIYNWRTVI NSATDLYFEG NIHQSLQNIP ENQLVQPALL QQKGGKGRKK LRLFEYLHES
     LCNPEMASCI QWIDQTKGIF QFVSKNKEKL AQLWGKRKGN RKTMTYQKMA RALRNYGRTG
     EIIKIRRKLT YQFSEAILQR LSAPYFLEKE IFYSQYVQPD QGYLSLNNWN ANYNYTYANY
     HELSHPDC