ID   SPIC_HUMAN              Reviewed;         248 AA.
AC   Q8N5J4;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 150.
DE   RecName: Full=Transcription factor Spi-C;
GN   Name=SPIC;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=12459275; DOI=10.1016/s0378-1119(02)01078-8;
RA   Carlsson R., Hjalmarsson A., Liberg D., Persson C., Leanderson T.;
RT   "Genomic structure of mouse SPI-C and genomic structure and expression
RT   pattern of human SPI-C.";
RL   Gene 299:271-278(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Pancreas;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Controls the development of red pulp macrophages required for
CC       red blood cells recycling and iron homeostasis. Transcription factor
CC       that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3')
CC       that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene
CC       expression (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Binds DNA as a monomer.
CC   -!- INTERACTION:
CC       Q8N5J4; Q5TA45: INTS11; NbExp=3; IntAct=EBI-12261246, EBI-748258;
CC       Q8N5J4; P50221: MEOX1; NbExp=3; IntAct=EBI-12261246, EBI-2864512;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Preferentially detected in fetal and adult spleen,
CC       lymph nodes and at lower levels in bone marrow and fetal liver.
CC       {ECO:0000269|PubMed:12459275}.
CC   -!- SIMILARITY: Belongs to the ETS family. {ECO:0000305}.
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DR   EMBL; BC032317; AAH32317.1; -; mRNA.
DR   EMBL; AF518404; AAN84476.1; -; mRNA.
DR   CCDS; CCDS9082.1; -.
DR   RefSeq; NP_689536.1; NM_152323.2.
DR   RefSeq; XP_005268703.1; XM_005268646.3.
DR   RefSeq; XP_006719302.1; XM_006719239.3.
DR   AlphaFoldDB; Q8N5J4; -.
DR   SMR; Q8N5J4; -.
DR   BioGRID; 125739; 4.
DR   IntAct; Q8N5J4; 3.
DR   STRING; 9606.ENSP00000448580; -.
DR   PhosphoSitePlus; Q8N5J4; -.
DR   BioMuta; SPIC; -.
DR   DMDM; 68566054; -.
DR   PaxDb; Q8N5J4; -.
DR   PRIDE; Q8N5J4; -.
DR   ProteomicsDB; 72069; -.
DR   Antibodypedia; 30388; 143 antibodies from 23 providers.
DR   DNASU; 121599; -.
DR   Ensembl; ENST00000551346.2; ENSP00000448580.1; ENSG00000166211.8.
DR   GeneID; 121599; -.
DR   KEGG; hsa:121599; -.
DR   MANE-Select; ENST00000551346.2; ENSP00000448580.1; NM_152323.3; NP_689536.1.
DR   UCSC; uc001tid.3; human.
DR   CTD; 121599; -.
DR   DisGeNET; 121599; -.
DR   GeneCards; SPIC; -.
DR   HGNC; HGNC:29549; SPIC.
DR   HPA; ENSG00000166211; Tissue enriched (lymphoid).
DR   MIM; 612568; gene.
DR   neXtProt; NX_Q8N5J4; -.
DR   OpenTargets; ENSG00000166211; -.
DR   PharmGKB; PA134897775; -.
DR   VEuPathDB; HostDB:ENSG00000166211; -.
DR   eggNOG; KOG3805; Eukaryota.
DR   GeneTree; ENSGT00940000155067; -.
DR   HOGENOM; CLU_098156_0_0_1; -.
DR   InParanoid; Q8N5J4; -.
DR   OMA; EIFYSPY; -.
DR   OrthoDB; 1272250at2759; -.
DR   PhylomeDB; Q8N5J4; -.
DR   TreeFam; TF318679; -.
DR   PathwayCommons; Q8N5J4; -.
DR   SignaLink; Q8N5J4; -.
DR   BioGRID-ORCS; 121599; 25 hits in 1038 CRISPR screens.
DR   GenomeRNAi; 121599; -.
DR   Pharos; Q8N5J4; Tbio.
DR   PRO; PR:Q8N5J4; -.
DR   Proteomes; UP000005640; Chromosome 12.
DR   RNAct; Q8N5J4; protein.
DR   Bgee; ENSG00000166211; Expressed in spleen and 37 other tissues.
DR   Genevisible; Q8N5J4; HS.
DR   GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0001824; P:blastocyst development; IEA:Ensembl.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR046328; ETS_fam.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11849; PTHR11849; 1.
DR   Pfam; PF00178; Ets; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..248
FT                   /note="Transcription factor Spi-C"
FT                   /id="PRO_0000204140"
FT   DNA_BIND        111..194
FT                   /note="ETS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00237"
SQ   SEQUENCE   248 AA;  29180 MW;  D4DC97EA0FFEE71E CRC64;
     MTCVEQDKLG QAFEDAFEVL RQHSTGDLQY SPDYRNYLAL INHRPHVKGN SSCYGVLPTE
     EPVYNWRTVI NSAADFYFEG NIHQSLQNIT ENQLVQPTLL QQKGGKGRKK LRLFEYLHES
     LYNPEMASCI QWVDKTKGIF QFVSKNKEKL AELWGKRKGN RKTMTYQKMA RALRNYGRSG
     EITKIRRKLT YQFSEAILQR LSPSYFLGKE IFYSQCVQPD QEYLSLNNWN ANYNYTYANY
     HELNHHDC