SPIK1_ADE41
ID SPIK1_ADE41 Reviewed; 562 AA.
AC P14267;
DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1990, sequence version 1.
DT 23-FEB-2022, entry version 90.
DE RecName: Full=Fiber protein 1;
OS Human adenovirus F serotype 41 (HAdV-41) (Human adenovirus 41).
OC Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes;
OC Rowavirales; Adenoviridae; Mastadenovirus; Human mastadenovirus F.
OX NCBI_TaxID=10524;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Tak;
RX PubMed=2587268; DOI=10.1093/nar/17.22.9474;
RA Pieniazek N.J., Slemenda S.B., Pieniazek D., Velarde J. Jr., Luftig R.B.;
RT "Sequence of human enteric adenovirus type 41 Tak fiber protein gene.";
RL Nucleic Acids Res. 17:9474-9474(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=FB585;
RX PubMed=2219717; DOI=10.1016/0042-6822(90)90283-w;
RA Kidd A.H., Erasmus M.J., Tiemessen C.T.;
RT "Fiber sequence heterogeneity in subgroup F adenoviruses.";
RL Virology 179:139-150(1990).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-14.
RC STRAIN=Tak;
RX PubMed=2336370; DOI=10.1093/nar/18.7.1901;
RA Pieniazek N.J., Slemenda S.B., Pieniazek D., Velarde J. Jr., Luftig R.B.;
RT "Human enteric adenovirus type 41 (Tak) contains a second fiber protein
RT gene.";
RL Nucleic Acids Res. 18:1901-1901(1990).
RN [4]
RP REVIEW.
RX PubMed=16160140; DOI=10.1128/jvi.79.19.12125-12131.2005;
RA Zhang Y., Bergelson J.M.;
RT "Adenovirus receptors.";
RL J. Virol. 79:12125-12131(2005).
CC -!- FUNCTION: Forms spikes that protrude from each vertex of the
CC icosahedral capsid. Interacts with host receptor CXCAR to provide
CC virion initial attachment to target cell. Fiber proteins are shed
CC during virus entry, when virus is still at the cell surface (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homotrimer. Interacts with host receptor CXCAR. Interacts (via
CC N-terminal tail region) with pentons (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}. Host nucleus {ECO:0000250}.
CC Note=Anchored to the pentons, protrudes from the virion surface.
CC {ECO:0000250}.
CC -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC -!- DOMAIN: The tail region anchors the fiber to penton base capsomers,
CC whereas the shaft, built from several repeated motifs, allows the knob
CC to protrude from the virion. {ECO:0000250}.
CC -!- MISCELLANEOUS: All late proteins expressed from the major late promoter
CC are produced by alternative splicing and alternative polyadenylation of
CC the same gene giving rise to non-overlapping ORFs. A leader sequence is
CC present in the N-terminus of all these mRNAs and is recognized by the
CC viral shutoff protein to provide expression although conventional
CC translation via ribosome scanning from the cap has been shut off in the
CC host cell (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the adenoviridae fiber family. {ECO:0000305}.
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DR EMBL; X16583; CAA34600.1; -; Genomic_DNA.
DR EMBL; M60327; AAA42506.1; -; Genomic_DNA.
DR EMBL; X17016; CAA34883.1; -; Genomic_DNA.
DR PIR; A34145; ERADN2.
DR SMR; P14267; -.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0019028; C:viral capsid; IEA:UniProtKB-KW.
DR GO; GO:0098671; P:adhesion receptor-mediated virion attachment to host cell; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR Gene3D; 2.60.90.10; -; 1.
DR InterPro; IPR000931; Adeno_fibre.
DR InterPro; IPR000978; Adeno_fibre_knob.
DR InterPro; IPR000939; Adenobir_fibre_prot_rpt/shaft.
DR InterPro; IPR008982; Adenovirus_pIV-like_att.
DR InterPro; IPR009013; Attachment_protein_shaft_sf.
DR Pfam; PF00541; Adeno_knob; 1.
DR Pfam; PF00608; Adeno_shaft; 8.
DR PRINTS; PR00307; ADENOVSFIBRE.
DR SUPFAM; SSF49835; SSF49835; 1.
DR SUPFAM; SSF51225; SSF51225; 4.
PE 2: Evidence at transcript level;
KW Capsid protein; Host nucleus; Host-virus interaction; Late protein;
KW Viral attachment to host adhesion receptor; Viral attachment to host cell;
KW Virion; Virus entry into host cell.
FT CHAIN 1..562
FT /note="Fiber protein 1"
FT /id="PRO_0000221801"
SQ SEQUENCE 562 AA; 60601 MW; 7677C06B29C46BFA CRC64;
MKRARLEDDF NPVYPYEHYN PLDIPFITPP FASSNGLQEK PPGVLSLKYT DPLTTKNGAL
TLKLGTGLNI DENGDLSSDA SVEVSAPITK TNKIVGLNYT KPLALRSNAL TLSYNAPLNV
VNNNLALNIS QPVTVNANNE LSLLIDAPLN ADTGTLRLQS AAPLGLVDKT LKVLFSSPLY
LDNNFLTLAI ERPLALSSSR AVTLKYSPPL KIENENLTLS TGGPFTVSGG NLNLTTSAPL
SVQNNSLSLV ITSPLKVINS MLAVGVNPPF TITDSGLAMD LGDGLALGGS KLIINLGPGL
QMSNGAITLA LDAALPLQYR DNQLQLRIGS TSGLIMSGVT QTLNVNANTG KGLAVENNSL
VVKLGNGLRF DSWGSITVSP TTTTPTTLWT TADPSPNATF YESLDAKVWL VLVKCNGMVN
GTISIKAQKG ILLRPTASFI SFVMYFYSDG TWRKNYPVFD NEGILANSAT WGYRQGQSAN
TNVSNAVEFM PSSKRYPNQK GSEVQNMALT YTFLQGDPNM AISFQSIYNH ALEGYSLKFT
WRVRNNERFD IPCCSFSYVT EQ