ID   SPIK2_ADE40             Reviewed;         387 AA.
AC   P18048;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 3.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=Fiber protein 2;
OS   Human adenovirus F serotype 40 (HAdV-40) (Human adenovirus 40).
OC   Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes;
OC   Rowavirales; Adenoviridae; Mastadenovirus; Human mastadenovirus F.
OX   NCBI_TaxID=28284;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Dugan;
RX   PubMed=8263936; DOI=10.1006/jmbi.1993.1687;
RA   Davison A.J., Telford E.A., Watson M.S., McBride K., Mautner V.;
RT   "The DNA sequence of adenovirus type 40.";
RL   J. Mol. Biol. 234:1308-1316(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8517033; DOI=10.1006/viro.1993.1009;
RA   Kidd A.H., Chroboczek J., Cusack S., Ruigrok R.W.H.;
RT   "Adenovirus type 40 virions contain two distinct fibers.";
RL   Virology 192:73-84(1993).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 167-387.
RX   PubMed=2773314; DOI=10.1016/0042-6822(89)90115-3;
RA   Kidd A.H., Erasmus M.J.;
RT   "Sequence characterization of the adenovirus 40 fiber gene.";
RL   Virology 172:134-144(1989).
RN   [4]
RP   REVIEW.
RX   PubMed=16160140; DOI=10.1128/jvi.79.19.12125-12131.2005;
RA   Zhang Y., Bergelson J.M.;
RT   "Adenovirus receptors.";
RL   J. Virol. 79:12125-12131(2005).
CC   -!- FUNCTION: Forms spikes that protrude from each vertex of the
CC       icosahedral capsid. Interacts with host receptor CXCAR to provide
CC       virion initial attachment to target cell. Fiber proteins are shed
CC       during virus entry, when virus is still at the cell surface (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homotrimer. Interacts with host receptor CXCAR. Interacts (via
CC       N-terminal tail region) with pentons (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}. Host nucleus {ECO:0000250}.
CC       Note=Anchored to the pentons, protrudes from the virion surface.
CC       {ECO:0000250}.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC   -!- DOMAIN: The tail region anchors the fiber to penton base capsomers,
CC       whereas the shaft, built from several repeated motifs, allows the knob
CC       to protrude from the virion. {ECO:0000250}.
CC   -!- MISCELLANEOUS: All late proteins expressed from the major late promoter
CC       are produced by alternative splicing and alternative polyadenylation of
CC       the same gene giving rise to non-overlapping ORFs. A leader sequence is
CC       present in the N-terminus of all these mRNAs and is recognized by the
CC       viral shutoff protein to provide expression although conventional
CC       translation via ribosome scanning from the cap has been shut off in the
CC       host cell (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the adenoviridae fiber family. {ECO:0000305}.
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DR   EMBL; L19443; AAC13979.1; -; Genomic_DNA.
DR   EMBL; M28822; AAA03233.1; -; Unassigned_DNA.
DR   PIR; A40048; ERADY4.
DR   RefSeq; NP_040875.1; NC_001454.1.
DR   SMR; P18048; -.
DR   GeneID; 2715923; -.
DR   KEGG; vg:2715923; -.
DR   Proteomes; UP000151954; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-KW.
DR   GO; GO:0098671; P:adhesion receptor-mediated virion attachment to host cell; IEA:UniProtKB-KW.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.90.10; -; 1.
DR   InterPro; IPR000931; Adeno_fibre.
DR   InterPro; IPR000978; Adeno_fibre_knob.
DR   InterPro; IPR000939; Adenobir_fibre_prot_rpt/shaft.
DR   InterPro; IPR008982; Adenovirus_pIV-like_att.
DR   InterPro; IPR009013; Attachment_protein_shaft_sf.
DR   Pfam; PF00541; Adeno_knob; 1.
DR   Pfam; PF00608; Adeno_shaft; 4.
DR   PRINTS; PR00307; ADENOVSFIBRE.
DR   SUPFAM; SSF49835; SSF49835; 1.
DR   SUPFAM; SSF51225; SSF51225; 2.
PE   2: Evidence at transcript level;
KW   Capsid protein; Host nucleus; Host-virus interaction; Late protein;
KW   Reference proteome; Viral attachment to host adhesion receptor;
KW   Viral attachment to host cell; Virion; Virus entry into host cell.
FT   CHAIN           1..387
FT                   /note="Fiber protein 2"
FT                   /id="PRO_0000221800"
FT   CONFLICT        226
FT                   /note="G -> S (in Ref. 2 and 3)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   387 AA;  41347 MW;  11A3C1FCD61A3ACB CRC64;
     MKRTRIEDDF NPVYPYDTSS TPSIPYVAPP FVSSDGLQEN PPGVLALKYT DPITTNAKHE
     LTLKLGSNIT LQNGLLSATV PTVSPPLTNS NNSLGLATSA PIAVSANSLT LATAAPLTVS
     NNQLSINTGR GLVITNNAVA VNPTGALGFN NTGALQLNAA GGMRVDGANL ILHVAYPFEA
     INQLTLRLEN GLEVTNGGKL NVKLGSGLQF DNNGRITISN RIQTRGVTSL TTIWSISPTP
     NCSIYETQDA NLFLCLTKNG AHVLGTITIK GLKGALREMN DNALSVKLPF DNQGNLLNCA
     LESSTWRYQE TNAVASNALT FMPNSTVYPR NKTADPGNML IQISPNITFS VVYNEINSGY
     AFTFKWSAEP GKPFHPPTAV FCYITEQ