ID   SPIKE_ADE04             Reviewed;         426 AA.
AC   P36844;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   12-AUG-2020, entry version 73.
DE   RecName: Full=Fiber protein;
DE            Short=SPIKE;
DE   AltName: Full=Protein IV;
GN   ORFNames=L5;
OS   Human adenovirus E serotype 4 (HAdV-4) (Human adenovirus 4).
OC   Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes;
OC   Rowavirales; Adenoviridae; Mastadenovirus; Human mastadenovirus E.
OX   NCBI_TaxID=28280;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Isolate RJ-67;
RA   Pring-Akerblom P., Adrian T.;
RL   Submitted (NOV-1993) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   REVIEW.
RX   PubMed=16160140; DOI=10.1128/jvi.79.19.12125-12131.2005;
RA   Zhang Y., Bergelson J.M.;
RT   "Adenovirus receptors.";
RL   J. Virol. 79:12125-12131(2005).
CC   -!- FUNCTION: Forms spikes that protrude from each vertex of the
CC       icosahedral capsid. Interacts with host receptor CXCAR to provide
CC       virion initial attachment to target cell. Fiber proteins are shed
CC       during virus entry, when virus is still at the cell surface (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homotrimer. Interacts with host receptor CXCAR. Interacts (via
CC       N-terminal tail region) with pentons (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}. Host nucleus {ECO:0000250}.
CC       Note=Anchored to the pentons, protrudes from the virion surface.
CC       {ECO:0000250}.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC   -!- DOMAIN: The tail region anchors the fiber to penton base capsomers,
CC       whereas the shaft, built from several repeated motifs, allows the knob
CC       to protrude from the virion. {ECO:0000250}.
CC   -!- MISCELLANEOUS: All late proteins expressed from the major late promoter
CC       are produced by alternative splicing and alternative polyadenylation of
CC       the same gene giving rise to non-overlapping ORFs. A leader sequence is
CC       present in the N-terminus of all these mRNAs and is recognized by the
CC       viral shutoff protein to provide expression although conventional
CC       translation via ribosome scanning from the cap has been shut off in the
CC       host cell (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the adenoviridae fiber family. {ECO:0000305}.
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DR   EMBL; X76547; CAA54049.1; -; Genomic_DNA.
DR   PIR; S39300; S39300.
DR   SMR; P36844; -.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-KW.
DR   GO; GO:0098671; P:adhesion receptor-mediated virion attachment to host cell; IEA:UniProtKB-KW.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.90.10; -; 1.
DR   InterPro; IPR000931; Adeno_fibre.
DR   InterPro; IPR000978; Adeno_fibre_knob.
DR   InterPro; IPR000939; Adenobir_fibre_prot_rpt/shaft.
DR   InterPro; IPR008982; Adenovirus_pIV-like_att.
DR   InterPro; IPR009013; Attachment_protein_shaft_sf.
DR   Pfam; PF00541; Adeno_knob; 1.
DR   Pfam; PF00608; Adeno_shaft; 3.
DR   PRINTS; PR00307; ADENOVSFIBRE.
DR   SUPFAM; SSF49835; SSF49835; 1.
DR   SUPFAM; SSF51225; SSF51225; 1.
PE   2: Evidence at transcript level;
KW   Capsid protein; Host nucleus; Host-virus interaction; Late protein;
KW   Viral attachment to host adhesion receptor; Viral attachment to host cell;
KW   Virion; Virus entry into host cell.
FT   CHAIN           1..426
FT                   /note="Fiber protein"
FT                   /id="PRO_0000221788"
SQ   SEQUENCE   426 AA;  45643 MW;  F780F5D0CF56D186 CRC64;
     MSKSARGWSD GFDPVYPYDA DNDRPCPSST LPSFSSDGFQ EKPLGVLSLG PGRPCHTKNG
     EITLKLGEGV DLDDSGKLIA NTVNKAIAPL SFFQQHHFPL TWIPLYTPKM ENYPYKFLPP
     LSILKSTILN TLVSAFGSGL GLSGSALAVQ LASPLTFDDK GNIKITLNRG LHVTTGDAIE
     SNISWAKGIK FEDGAIATNI GKGSRFGTSS TETGVNNAYP IQVKLGSGLS FDSTGAIMAG
     NKDYDKLTLW TTPDPSPNCQ ILAENDAKLT LCLTMCDSQI LATVSVLVVR SGNLNPITGT
     VSSAQVFLRF DANGVLLTEH STSKKYWGYK QGDSIDGTPY TNAVGFMPNS TAYPKTQSST
     TKNNIVGQVY MNGDVSKPML LTITLNGTDD TTSAYSMSFS YTWTNGSYIG ATFGANSYTF
     SYIAQQ