ID   SPIKE_ADE08             Reviewed;         362 AA.
AC   P36845;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   12-AUG-2020, entry version 81.
DE   RecName: Full=Fiber protein;
DE            Short=SPIKE;
DE   AltName: Full=Protein IV;
GN   ORFNames=L5;
OS   Human adenovirus D serotype 8 (HAdV-8) (Human adenovirus 8).
OC   Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes;
OC   Rowavirales; Adenoviridae; Mastadenovirus; Human mastadenovirus D.
OX   NCBI_TaxID=31545;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Isolate 1127;
RX   PubMed=7831811; DOI=10.1016/s0042-6822(95)80073-5;
RA   Pring-Akerblom P., Adrian T.;
RT   "Characterization of adenovirus subgenus D fiber genes.";
RL   Virology 206:564-571(1995).
RN   [2]
RP   REVIEW.
RX   PubMed=16160140; DOI=10.1128/jvi.79.19.12125-12131.2005;
RA   Zhang Y., Bergelson J.M.;
RT   "Adenovirus receptors.";
RL   J. Virol. 79:12125-12131(2005).
CC   -!- FUNCTION: Forms spikes that protrude from each vertex of the
CC       icosahedral capsid. Interacts with host sialic acid to provide virion
CC       initial attachment to target cell. Fiber proteins are shed during virus
CC       entry, when virus is still at the cell surface.
CC   -!- SUBUNIT: Homotrimer. Interacts with host sialic acid. Interacts (via N-
CC       terminal tail region) with pentons (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}. Host nucleus {ECO:0000250}.
CC       Note=Anchored to the pentons, protrudes from the virion surface.
CC       {ECO:0000250}.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC   -!- DOMAIN: The tail region anchors the fiber to penton base capsomers,
CC       whereas the shaft, built from several repeated motifs, allows the knob
CC       to protrude from the virion. {ECO:0000250}.
CC   -!- MISCELLANEOUS: All late proteins expressed from the major late promoter
CC       are produced by alternative splicing and alternative polyadenylation of
CC       the same gene giving rise to non-overlapping ORFs. A leader sequence is
CC       present in the N-terminus of all these mRNAs and is recognized by the
CC       viral shutoff protein to provide expression although conventional
CC       translation via ribosome scanning from the cap has been shut off in the
CC       host cell (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the adenoviridae fiber family. {ECO:0000305}.
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DR   EMBL; X74660; CAA52724.1; -; Genomic_DNA.
DR   PIR; S37218; S37218.
DR   SMR; P36845; -.
DR   PRIDE; P36845; -.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-KW.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.90.10; -; 1.
DR   InterPro; IPR000931; Adeno_fibre.
DR   InterPro; IPR000978; Adeno_fibre_knob.
DR   InterPro; IPR008982; Adenovirus_pIV-like_att.
DR   InterPro; IPR009013; Attachment_protein_shaft_sf.
DR   Pfam; PF00541; Adeno_knob; 1.
DR   PRINTS; PR00307; ADENOVSFIBRE.
DR   SUPFAM; SSF49835; SSF49835; 1.
DR   SUPFAM; SSF51225; SSF51225; 2.
PE   2: Evidence at transcript level;
KW   Capsid protein; Host nucleus; Host-virus interaction; Late protein;
KW   Viral attachment to host cell; Virion; Virus entry into host cell.
FT   CHAIN           1..362
FT                   /note="Fiber protein"
FT                   /id="PRO_0000221791"
SQ   SEQUENCE   362 AA;  39661 MW;  C7ECBE5DA13EFF86 CRC64;
     MTKRLRAEDD FNPVYPYGYA RNQNIPFLTP PFVSSNGFQN FPPGVLSLKL ADPITINNQN
     VSLKVGGGLT LQEETGKLTV NTEPPLHLTN NKLGIALDAP FDVIDNKLTL LAGHGLSIIT
     KETSTLPGLV NTLVVLTGKG IGTDLSNNGG NICVRVGEGG GLSFNDNGDL VAFNKKEDKR
     TLWTTPDTSP NCRIDQDKDS KLSLVLTKCG SQILANVSLI VVAGRYKIIN NNTNPALKGF
     TIKLLFDKNG VLMESSNLGK SYWNFRNQNS IMSTAYEKAI GFMPNLVAYP KPTTGSKKYA
     RDIVYGNIYL GGKPHQPVTI KTTFNQETGC EYSITFDFSW AKTYVNVEFE TTSFTFSYIA
     QE