ID   SPIKE_ADE09             Reviewed;         362 AA.
AC   P68982; P36846;
DT   01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   02-DEC-2020, entry version 63.
DE   RecName: Full=Fiber protein;
DE            Short=SPIKE;
DE   AltName: Full=Protein IV;
GN   ORFNames=L5;
OS   Human adenovirus D serotype 9 (HAdV-9) (Human adenovirus 9).
OC   Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes;
OC   Rowavirales; Adenoviridae; Mastadenovirus; Human mastadenovirus D.
OX   NCBI_TaxID=10527;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Isolate ATCC VR-1086 / Hicks / V-209-003-014;
RX   PubMed=7831811; DOI=10.1016/s0042-6822(95)80073-5;
RA   Pring-Akerblom P., Adrian T.;
RT   "Characterization of adenovirus subgenus D fiber genes.";
RL   Virology 206:564-571(1995).
RN   [2]
RP   REVIEW.
RX   PubMed=16160140; DOI=10.1128/jvi.79.19.12125-12131.2005;
RA   Zhang Y., Bergelson J.M.;
RT   "Adenovirus receptors.";
RL   J. Virol. 79:12125-12131(2005).
CC   -!- FUNCTION: Forms spikes that protrude from each vertex of the
CC       icosahedral capsid. Interacts with host receptor CXCAR to provide
CC       virion initial attachment to target cell. Fiber proteins are shed
CC       during virus entry, when virus is still at the cell surface (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homotrimer. Interacts with host receptor CXCAR. Interacts (via
CC       N-terminal tail region) with pentons (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}. Host nucleus {ECO:0000250}.
CC       Note=Anchored to the pentons, protrudes from the virion surface.
CC       {ECO:0000250}.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC   -!- DOMAIN: The tail region anchors the fiber to penton base capsomers,
CC       whereas the shaft, built from several repeated motifs, allows the knob
CC       to protrude from the virion. {ECO:0000250}.
CC   -!- MISCELLANEOUS: All late proteins expressed from the major late promoter
CC       are produced by alternative splicing and alternative polyadenylation of
CC       the same gene giving rise to non-overlapping ORFs. A leader sequence is
CC       present in the N-terminus of all these mRNAs and is recognized by the
CC       viral shutoff protein to provide expression although conventional
CC       translation via ribosome scanning from the cap has been shut off in the
CC       host cell (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the adenoviridae fiber family. {ECO:0000305}.
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DR   EMBL; X74659; CAA52723.1; -; Genomic_DNA.
DR   PIR; S37220; S37220.
DR   SMR; P68982; -.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-KW.
DR   GO; GO:0098671; P:adhesion receptor-mediated virion attachment to host cell; IEA:UniProtKB-KW.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.90.10; -; 1.
DR   InterPro; IPR000931; Adeno_fibre.
DR   InterPro; IPR000978; Adeno_fibre_knob.
DR   InterPro; IPR008982; Adenovirus_pIV-like_att.
DR   InterPro; IPR009013; Attachment_protein_shaft_sf.
DR   Pfam; PF00541; Adeno_knob; 1.
DR   PRINTS; PR00307; ADENOVSFIBRE.
DR   SUPFAM; SSF49835; SSF49835; 1.
DR   SUPFAM; SSF51225; SSF51225; 2.
PE   2: Evidence at transcript level;
KW   Capsid protein; Host nucleus; Host-virus interaction; Late protein;
KW   Viral attachment to host adhesion receptor; Viral attachment to host cell;
KW   Virion; Virus entry into host cell.
FT   CHAIN           1..362
FT                   /note="Fiber protein"
FT                   /id="PRO_0000221792"
SQ   SEQUENCE   362 AA;  39420 MW;  2662E5546A9C4DA0 CRC64;
     MSKRLRVEDD FNPVYPYGYA RNQNIPFLTP PFVSSDGFQN FPPGVLSLKL ADPIAIVNGN
     VSLKVGGGLT LQDGTGKLTV NADPPLQLTN NKLGIALDAP FDVIDNKLTL LAGHGLSIIT
     KETSTLPGLR NTLVVLTGKG IGTESTDNGG TVCVRVGEGG GLSFNNDGDL VAFNKKEDKR
     TLWTTPDTSP NCKIDQDKDS KLTLVLTKCG SQILANVSLI VVDGKYKIIN NNTQPALKGF
     TIKLLFDENG VLMESSNLGK SYWNFRNENS IMSTAYEKAI GFMPNLVAYP KPTAGSKKYA
     RDIVYGNIYL GGKPDQPVTI KTTFNQETGC EYSITFDFSW AKTYVNVEFE TTSFTFSYIA
     QE