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SPIKE_ADE15
ID   SPIKE_ADE15             Reviewed;         367 AA.
AC   P36847;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Fiber protein;
DE            Short=SPIKE;
DE   AltName: Full=Protein IV;
GN   ORFNames=L5;
OS   Human adenovirus D serotype 15 (HAdV-15) (Human adenovirus 15).
OC   Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes;
OC   Rowavirales; Adenoviridae; Mastadenovirus; Human mastadenovirus D.
OX   NCBI_TaxID=28276;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Isolate HXB2956;
RX   PubMed=7491756; DOI=10.1006/viro.1995.0004;
RA   Eiz B., Adrian T., Pring-Akerblom P.;
RT   "Immunological adenovirus variant strains of subgenus D: comparison of the
RT   hexon and fiber sequences.";
RL   Virology 213:313-320(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Isolate HXB2956, and Isolate HXH10009;
RX   PubMed=7831811; DOI=10.1016/s0042-6822(95)80073-5;
RA   Pring-Akerblom P., Adrian T.;
RT   "Characterization of adenovirus subgenus D fiber genes.";
RL   Virology 206:564-571(1995).
RN   [3]
RP   REVIEW.
RX   PubMed=16160140; DOI=10.1128/jvi.79.19.12125-12131.2005;
RA   Zhang Y., Bergelson J.M.;
RT   "Adenovirus receptors.";
RL   J. Virol. 79:12125-12131(2005).
CC   -!- FUNCTION: Forms spikes that protrude from each vertex of the
CC       icosahedral capsid. Interacts with host receptor CXCAR to provide
CC       virion initial attachment to target cell. Fiber proteins are shed
CC       during virus entry, when virus is still at the cell surface (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homotrimer. Interacts with host receptor CXCAR. Interacts (via
CC       N-terminal tail region) with pentons (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}. Host nucleus {ECO:0000250}.
CC       Note=Anchored to the pentons, protrudes from the virion surface.
CC       {ECO:0000250}.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC   -!- DOMAIN: The tail region anchors the fiber to penton base capsomers,
CC       whereas the shaft, built from several repeated motifs, allows the knob
CC       to protrude from the virion. {ECO:0000250}.
CC   -!- MISCELLANEOUS: All late proteins expressed from the major late promoter
CC       are produced by alternative splicing and alternative polyadenylation of
CC       the same gene giving rise to non-overlapping ORFs. A leader sequence is
CC       present in the N-terminus of all these mRNAs and is recognized by the
CC       viral shutoff protein to provide expression although conventional
CC       translation via ribosome scanning from the cap has been shut off in the
CC       host cell (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the adenoviridae fiber family. {ECO:0000305}.
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DR   EMBL; X72935; CAA51440.1; -; Genomic_DNA.
DR   EMBL; X72936; CAA51441.1; -; Genomic_DNA.
DR   EMBL; X74669; CAA52733.1; -; Genomic_DNA.
DR   PIR; S32664; S32664.
DR   PDB; 6STW; X-ray; 1.37 A; A/B/C=178-367.
DR   PDBsum; 6STW; -.
DR   SMR; P36847; -.
DR   PRIDE; P36847; -.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-KW.
DR   GO; GO:0098671; P:adhesion receptor-mediated virion attachment to host cell; IEA:UniProtKB-KW.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.90.10; -; 1.
DR   InterPro; IPR000931; Adeno_fibre.
DR   InterPro; IPR000978; Adeno_fibre_knob.
DR   InterPro; IPR008982; Adenovirus_pIV-like_att.
DR   InterPro; IPR009013; Attachment_protein_shaft_sf.
DR   Pfam; PF00541; Adeno_knob; 1.
DR   PRINTS; PR00307; ADENOVSFIBRE.
DR   SUPFAM; SSF49835; SSF49835; 1.
DR   SUPFAM; SSF51225; SSF51225; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Capsid protein; Host nucleus; Host-virus interaction;
KW   Late protein; Viral attachment to host adhesion receptor;
KW   Viral attachment to host cell; Virion; Virus entry into host cell.
FT   CHAIN           1..367
FT                   /note="Fiber protein"
FT                   /id="PRO_0000221796"
FT   STRAND          181..184
FT                   /evidence="ECO:0007829|PDB:6STW"
FT   STRAND          194..196
FT                   /evidence="ECO:0007829|PDB:6STW"
FT   STRAND          200..209
FT                   /evidence="ECO:0007829|PDB:6STW"
FT   STRAND          212..221
FT                   /evidence="ECO:0007829|PDB:6STW"
FT   HELIX           225..228
FT                   /evidence="ECO:0007829|PDB:6STW"
FT   TURN            231..233
FT                   /evidence="ECO:0007829|PDB:6STW"
FT   HELIX           237..240
FT                   /evidence="ECO:0007829|PDB:6STW"
FT   STRAND          241..248
FT                   /evidence="ECO:0007829|PDB:6STW"
FT   STRAND          258..260
FT                   /evidence="ECO:0007829|PDB:6STW"
FT   HELIX           282..284
FT                   /evidence="ECO:0007829|PDB:6STW"
FT   TURN            288..290
FT                   /evidence="ECO:0007829|PDB:6STW"
FT   STRAND          308..315
FT                   /evidence="ECO:0007829|PDB:6STW"
FT   STRAND          322..330
FT                   /evidence="ECO:0007829|PDB:6STW"
FT   STRAND          335..344
FT                   /evidence="ECO:0007829|PDB:6STW"
FT   STRAND          350..352
FT                   /evidence="ECO:0007829|PDB:6STW"
FT   STRAND          359..365
FT                   /evidence="ECO:0007829|PDB:6STW"
SQ   SEQUENCE   367 AA;  39983 MW;  E7A4B930929C5E0C CRC64;
     MSKRLRVEDD FNPVYPYGYA RNQNIPFLTP PFVSSDGFQN FPPGVLSLKL ADPIAIANGN
     VSLKMGGGLT LQEGTGNLTV NTEPPLQLTN NRIGIALDAP FDVIGGKLTL LAGHGLSIIT
     EETSPLPGLV NTLVVLTGKG LGTDTTDNGG SIRVRVGEGG GLSFNEAGDL VAFNKKEDMR
     TLWTTPDPSP NCKIIEDKDS KLTLILTKCG SQILGSVSLL VVKGKFSNIN NTTNPNEADK
     QITVKLLFDA NGVLKQGSTM DSSYWNYRSD NSNLSQPYKK AVGFMPSKTA YPKQTKPTNK
     EISQAKNKIV SNVYLGGKID QPCVIIISFN EEADSDYSIV FYFKWYKTYE NVQFDSSSFN
     FSYIAQE
 
 
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