ID   SPIKE_ADE1A             Reviewed;         325 AA.
AC   P35773;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   12-AUG-2020, entry version 80.
DE   RecName: Full=Fiber protein;
DE            Short=SPIKE;
DE   AltName: Full=Protein IV;
GN   ORFNames=L5;
OS   Human adenovirus B serotype 11 (strain BC34) (HAdV-11) (Human adenovirus
OS   11A (strain BC34)).
OC   Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes;
OC   Rowavirales; Adenoviridae; Mastadenovirus; Human mastadenovirus B.
OX   NCBI_TaxID=343463;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8503168; DOI=10.1006/viro.1993.1284;
RA   Mei Y.-F., Wadell G.;
RT   "Hemagglutination properties and nucleotide sequence analysis of the fiber
RT   gene of adenovirus genome types 11p and 11a.";
RL   Virology 194:453-462(1993).
RN   [2]
RP   REVIEW.
RX   PubMed=16160140; DOI=10.1128/jvi.79.19.12125-12131.2005;
RA   Zhang Y., Bergelson J.M.;
RT   "Adenovirus receptors.";
RL   J. Virol. 79:12125-12131(2005).
CC   -!- FUNCTION: Forms spikes that protrude from each vertex of the
CC       icosahedral capsid. Interacts with host receptor CD46 to provide virion
CC       initial attachment to target cell. Fiber proteins are shed during virus
CC       entry, when virus is still at the cell surface.
CC   -!- SUBUNIT: Homotrimer. Interacts with host receptor CD46. Interacts (via
CC       N-terminal tail region) with pentons (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}. Host nucleus {ECO:0000250}.
CC       Note=Anchored to the pentons, protrudes from the virion surface.
CC       {ECO:0000250}.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC   -!- DOMAIN: The tail region anchors the fiber to penton base capsomers,
CC       whereas the shaft, built from several repeated motifs, allows the knob
CC       to protrude from the virion. {ECO:0000250}.
CC   -!- MISCELLANEOUS: All late proteins expressed from the major late promoter
CC       are produced by alternative splicing and alternative polyadenylation of
CC       the same gene giving rise to non-overlapping ORFs. A leader sequence is
CC       present in the N-terminus of all these mRNAs and is recognized by the
CC       viral shutoff protein to provide expression although conventional
CC       translation via ribosome scanning from the cap has been shut off in the
CC       host cell (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the adenoviridae fiber family. {ECO:0000305}.
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DR   EMBL; L08232; AAA42491.1; -; Genomic_DNA.
DR   SMR; P35773; -.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-KW.
DR   GO; GO:0098671; P:adhesion receptor-mediated virion attachment to host cell; IEA:UniProtKB-KW.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.90.10; -; 1.
DR   InterPro; IPR000931; Adeno_fibre.
DR   InterPro; IPR000978; Adeno_fibre_knob.
DR   InterPro; IPR000939; Adenobir_fibre_prot_rpt/shaft.
DR   InterPro; IPR008982; Adenovirus_pIV-like_att.
DR   InterPro; IPR009013; Attachment_protein_shaft_sf.
DR   Pfam; PF00541; Adeno_knob; 1.
DR   Pfam; PF00608; Adeno_shaft; 2.
DR   PRINTS; PR00307; ADENOVSFIBRE.
DR   SUPFAM; SSF49835; SSF49835; 1.
DR   SUPFAM; SSF51225; SSF51225; 1.
PE   2: Evidence at transcript level;
KW   Capsid protein; Host nucleus; Host-virus interaction; Late protein;
KW   Viral attachment to host adhesion receptor; Viral attachment to host cell;
KW   Virion; Virus entry into host cell.
FT   CHAIN           1..325
FT                   /note="Fiber protein"
FT                   /id="PRO_0000221793"
SQ   SEQUENCE   325 AA;  35331 MW;  2109E69685A078B9 CRC64;
     MTKRVRLSDS FNPVYPYEDE STSQHPFINP GFISPNGFTQ SPDGVLTLKC LTPLTTTGGS
     LQLKVGGGLT VDDTDGTLQE NIGTTTPLVK TGHSIGLSLG AGLGTDENKL CTKLGKGLTF
     NSNNICIDDN INTLWTGINP TEANCQMMDS SESNDCKLIL TLVKTGALVT AFVYVIGVSN
     NFNMLTTYRN INFTAELFFD SAGNLLTSLS SLKTPLNHKS GQNMATGAIT NAKSFMPSTT
     AYPFNNNSRE KENYIYGTCH YTASDHTAFP IDISVMLNQR AIRADTSYCI RITWSWNTGD
     APEGQTSATT LVTSPFTFYY IREDD