ID   SPIKE_ADE31             Reviewed;         556 AA.
AC   P36848;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   02-JUN-2021, entry version 84.
DE   RecName: Full=Fiber protein;
DE            Short=SPIKE;
DE   AltName: Full=Protein IV;
GN   ORFNames=L5;
OS   Human adenovirus A serotype 31 (HAdV-31) (Human adenovirus 31).
OC   Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes;
OC   Rowavirales; Adenoviridae; Mastadenovirus; Human mastadenovirus A.
OX   NCBI_TaxID=10529;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=VRL 15/62;
RX   PubMed=8578008; DOI=10.1016/0923-2516(96)80597-8;
RA   Pring-Akerblom P., Adrian T.;
RT   "Sequence characterization of the adenovirus 31 fibre and comparison with
RT   serotypes of subgenera A to F.";
RL   Res. Virol. 146:343-354(1995).
RN   [2]
RP   REVIEW.
RX   PubMed=16160140; DOI=10.1128/jvi.79.19.12125-12131.2005;
RA   Zhang Y., Bergelson J.M.;
RT   "Adenovirus receptors.";
RL   J. Virol. 79:12125-12131(2005).
CC   -!- FUNCTION: Forms spikes that protrude from each vertex of the
CC       icosahedral capsid. Interacts with host receptor CXCAR to provide
CC       virion initial attachment to target cell. Fiber proteins are shed
CC       during virus entry, when virus is still at the cell surface (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homotrimer. Interacts with host receptor CXCAR. Interacts (via
CC       N-terminal tail region) with pentons (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}. Host nucleus {ECO:0000250}.
CC       Note=Anchored to the pentons, protrudes from the virion surface.
CC       {ECO:0000250}.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC   -!- DOMAIN: The tail region anchors the fiber to penton base capsomers,
CC       whereas the shaft, built from several repeated motifs, allows the knob
CC       to protrude from the virion. {ECO:0000250}.
CC   -!- MISCELLANEOUS: All late proteins expressed from the major late promoter
CC       are produced by alternative splicing and alternative polyadenylation of
CC       the same gene giving rise to non-overlapping ORFs. A leader sequence is
CC       present in the N-terminus of all these mRNAs and is recognized by the
CC       viral shutoff protein to provide expression although conventional
CC       translation via ribosome scanning from the cap has been shut off in the
CC       host cell (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the adenoviridae fiber family. {ECO:0000305}.
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DR   EMBL; X76548; CAA54050.1; -; Genomic_DNA.
DR   PIR; S39297; S39297.
DR   SMR; P36848; -.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-KW.
DR   GO; GO:0098671; P:adhesion receptor-mediated virion attachment to host cell; IEA:UniProtKB-KW.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.90.10; -; 1.
DR   InterPro; IPR000931; Adeno_fibre.
DR   InterPro; IPR000978; Adeno_fibre_knob.
DR   InterPro; IPR000939; Adenobir_fibre_prot_rpt/shaft.
DR   InterPro; IPR008982; Adenovirus_pIV-like_att.
DR   InterPro; IPR009013; Attachment_protein_shaft_sf.
DR   Pfam; PF00541; Adeno_knob; 1.
DR   Pfam; PF00608; Adeno_shaft; 5.
DR   PRINTS; PR00307; ADENOVSFIBRE.
DR   SUPFAM; SSF49835; SSF49835; 1.
DR   SUPFAM; SSF51225; SSF51225; 3.
PE   2: Evidence at transcript level;
KW   Capsid protein; Host nucleus; Host-virus interaction; Late protein;
KW   Viral attachment to host adhesion receptor; Viral attachment to host cell;
KW   Virion; Virus entry into host cell.
FT   CHAIN           1..556
FT                   /note="Fiber protein"
FT                   /id="PRO_0000221798"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   556 AA;  58944 MW;  6FB13A60ED1D0C33 CRC64;
     MKRSRTQYAE EPEENDDFNP VYPFDPYDTA HVPFVTPPFT SSNAFQEKPP GVLSLNYKDP
     IVTENGSLTL KLGNGIKLNS QGQLTTTNTK VLEPLPHTSQ GLTLSWSAPL SVKASALTLN
     TMAPFTTTNE SLSLVTAPPI TVEASQLGLA SCSTSKLRGG GNLGFHLPAP FVVPSSNALT
     LSASDPLTVN SNSLGLNITS PITLINGSLA LATSPPLDTT GSTLNLSVAA PLSVSQNALT
     VSTGNGLQVS GSQLVTRIGD GLRFDNGVIK AHVAGGNETL RGKIILDVNY PFDATTNLSL
     RRGSGLIYNE STNWNLTTDI STEKGLTFSG NQIAINAGPC GLTFNNRKLQ VKLGAGHTFS
     SNDNIALNSI ATPYDPLTLW TTPDPPPNCT LRQELDAKLT LCLTKNESIV NGIVSLIGVK
     GDLLHIQPTT TTVGLHLVFD RQGRLVTTTP TALVPQASWG YKQGQSVSSS AVANALGFMP
     NVSAYPRPNA GEAKSQMLSQ TYLQGDTTKP ITMKVVFNGN ATVDGYSLTF MWTGVSNYLN
     QQFSTPSCSF SYIAQE