ID   SPIKE_ADECR             Reviewed;         543 AA.
AC   Q96689;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   02-JUN-2021, entry version 85.
DE   RecName: Full=Fiber protein;
DE            Short=SPIKE;
DE   AltName: Full=Protein IV;
GN   ORFNames=L5;
OS   Canine adenovirus serotype 1 (strain RI261) (CAdV-1) (Canine adenovirus 1
OS   (strain RI261)).
OC   Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes;
OC   Rowavirales; Adenoviridae; Mastadenovirus; Canine mastadenovirus A.
OX   NCBI_TaxID=69151;
OH   NCBI_TaxID=9615; Canis lupus familiaris (Dog) (Canis familiaris).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=9129661; DOI=10.1099/0022-1317-78-4-873;
RA   Morrison M.D., Onions D.E., Nicolson L.;
RT   "Complete DNA sequence of canine adenovirus type 1.";
RL   J. Gen. Virol. 78:873-878(1997).
CC   -!- FUNCTION: Forms spikes that protrude from each vertex of the
CC       icosahedral capsid. Interacts with host receptor to provide virion
CC       initial attachment to target cell. Fiber proteins are shed during virus
CC       entry, when virus is still at the cell surface (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homotrimer. Interacts (via N-terminal tail region) with
CC       pentons (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}. Host nucleus {ECO:0000250}.
CC       Note=Anchored to the pentons, protrudes from the virion surface.
CC       {ECO:0000250}.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC   -!- DOMAIN: The tail region anchors the fiber to penton base capsomers,
CC       whereas the shaft, built from several repeated motifs, allows the knob
CC       to protrude from the virion. {ECO:0000250}.
CC   -!- MISCELLANEOUS: All late proteins expressed from the major late promoter
CC       are produced by alternative splicing and alternative polyadenylation of
CC       the same gene giving rise to non-overlapping ORFs. A leader sequence is
CC       present in the N-terminus of all these mRNAs and is recognized by the
CC       viral shutoff protein to provide expression although conventional
CC       translation via ribosome scanning from the cap has been shut off in the
CC       host cell (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the adenoviridae fiber family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Y07760; CAA69045.1; -; Genomic_DNA.
DR   RefSeq; AP_000069.1; AC_000003.1.
DR   RefSeq; NP_044207.1; NC_001734.1.
DR   SMR; Q96689; -.
DR   GeneID; 1488941; -.
DR   KEGG; vg:1488941; -.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-KW.
DR   GO; GO:0098671; P:adhesion receptor-mediated virion attachment to host cell; IEA:UniProtKB-KW.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.90.10; -; 1.
DR   InterPro; IPR000931; Adeno_fibre.
DR   InterPro; IPR000939; Adenobir_fibre_prot_rpt/shaft.
DR   InterPro; IPR008982; Adenovirus_pIV-like_att.
DR   InterPro; IPR009013; Attachment_protein_shaft_sf.
DR   Pfam; PF00608; Adeno_shaft; 7.
DR   PRINTS; PR00307; ADENOVSFIBRE.
DR   SUPFAM; SSF49835; SSF49835; 1.
DR   SUPFAM; SSF51225; SSF51225; 3.
PE   2: Evidence at transcript level;
KW   Capsid protein; Host nucleus; Host-virus interaction; Late protein;
KW   Viral attachment to host adhesion receptor; Viral attachment to host cell;
KW   Virion; Virus entry into host cell.
FT   CHAIN           1..543
FT                   /note="Fiber protein"
FT                   /id="PRO_0000221806"
FT   REGION          1..36
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   543 AA;  56974 MW;  36CC8094D3E22E26 CRC64;
     MKRTRSALPA NFDPVYPYDA PKPSTQPPFF NDRKGLTESS PGTLAVNISP PLTFSNLGAI
     KLSTGAGLIL KEGKLEANIG PGLTTNQEGQ ITVEKDSDGL TFTSPLHKIE NTVSLSIGEG
     LEDESGTLKV NFPSPPPPLL FSPPLAEAGG TVSLPLQESM QVTEGKLGVK PTTYSPPLQK
     TDQQVSLRVG PGLTVLNGQL QAVQPPATTY KEPLLETENS VSLKVGAGLA VQDGALVATP
     PNVTFSAPLE KNGNAVSVRV GAGLSIQGNA LVATTSPTLT FAYPLIKNNN HITLSAGSGL
     RVSGGSLTVA TGPGLSHING TIAAVIGAGL KFENNAILAK LGNGLTIRDG AIEAVAPQPS
     FTPVTLWTGP DPNVNTSING TPVIRSFISL TRDSNLVTVN ASFTGEGSYQ SVSPTQSQFS
     LILEFNQFGQ LMSTGNLNST TTWGEKPWGN NTVQVQPSHT WKLCMPNREV YSTPAATLTS
     CGLNSIAHDG APNRSIDCML IINKLAGAAT YTLTFRFLNF NKLSSSTVFK TDVLTFTYVG
     ENQ