ID   SPIKE_ADEM1             Reviewed;         613 AA.
AC   P19721;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   23-FEB-2022, entry version 90.
DE   RecName: Full=Fiber protein;
DE            Short=SPIKE;
DE   AltName: Full=Protein IV;
GN   ORFNames=L5;
OS   Murine adenovirus A serotype 1 (MAdV-1) (Murine adenovirus 1).
OC   Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes;
OC   Rowavirales; Adenoviridae; Mastadenovirus; Murine mastadenovirus A.
OX   NCBI_TaxID=10530;
OH   NCBI_TaxID=10090; Mus musculus (Mouse).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2531236; DOI=10.1128/jvi.63.12.5455-5458.1989;
RA   Raviprakash K.S., Grunhaus A., el Kholy M.A., Horwitz M.S.;
RT   "The mouse adenovirus type 1 contains an unusual E3 region.";
RL   J. Virol. 63:5455-5458(1989).
CC   -!- FUNCTION: Forms spikes that protrude from each vertex of the
CC       icosahedral capsid. Interacts with host receptor to provide virion
CC       initial attachment to target cell. Fiber proteins are shed during virus
CC       entry, when virus is still at the cell surface (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homotrimer. Interacts (via N-terminal tail region) with
CC       pentons (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}. Host nucleus {ECO:0000250}.
CC       Note=Anchored to the pentons, protrudes from the virion surface.
CC       {ECO:0000250}.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC   -!- DOMAIN: The tail region anchors the fiber to penton base capsomers,
CC       whereas the shaft, built from several repeated motifs, allows the knob
CC       to protrude from the virion. {ECO:0000250}.
CC   -!- MISCELLANEOUS: All late proteins expressed from the major late promoter
CC       are produced by alternative splicing and alternative polyadenylation of
CC       the same gene giving rise to non-overlapping ORFs. A leader sequence is
CC       present in the N-terminus of all these mRNAs and is recognized by the
CC       viral shutoff protein to provide expression although conventional
CC       translation via ribosome scanning from the cap has been shut off in the
CC       host cell (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the adenoviridae fiber family. {ECO:0000305}.
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DR   EMBL; M30594; AAA42434.1; -; Genomic_DNA.
DR   PIR; C33382; ERADFM.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-KW.
DR   GO; GO:0098671; P:adhesion receptor-mediated virion attachment to host cell; IEA:UniProtKB-KW.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.90.10; -; 2.
DR   InterPro; IPR000931; Adeno_fibre.
DR   InterPro; IPR000939; Adenobir_fibre_prot_rpt/shaft.
DR   InterPro; IPR008982; Adenovirus_pIV-like_att.
DR   InterPro; IPR009013; Attachment_protein_shaft_sf.
DR   Pfam; PF00608; Adeno_shaft; 5.
DR   PRINTS; PR00307; ADENOVSFIBRE.
DR   SUPFAM; SSF49835; SSF49835; 1.
DR   SUPFAM; SSF51225; SSF51225; 3.
PE   2: Evidence at transcript level;
KW   Capsid protein; Host nucleus; Host-virus interaction; Late protein;
KW   Viral attachment to host adhesion receptor; Viral attachment to host cell;
KW   Virion; Virus entry into host cell.
FT   CHAIN           1..613
FT                   /note="Fiber protein"
FT                   /id="PRO_0000221810"
FT   REGION          474..496
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        474..493
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   613 AA;  66802 MW;  4C6E7936DD594247 CRC64;
     MVEALNAVYP YDLALLPEDY EKTTAPDAVQ AANAARPFLN PVYPYQQPVA GDFGFPIVMP
     PFFNSYDFTS IHGNTLSLRL NKPLKRTAKG LQLLLGSGLS VNADGQLESS EGISEADAPL
     QINDGVLQLS FGEGLSVNDH GELESKGKVE AVTLPLALQD HVMSLSFGQG LQVNDQGQLE
     ALAMVHSTSA PLKVTNNNLE LALGRGLIVD DQGQLRLAPN LLWPESPLAI EQGTNHLILF
     YNQSLDVEDG KLTLPEPFDP LTLDGGRLRM QLAPNSGLAV TEKGSLGINW GEGIQVKEQK
     ITLKVTPANG LAVTEQGGLN INWGNGIKVD EQKVTLKTSN EFALTENGLY LTSPLNPIEV
     NQHGQLGIAL GYGFHAHRGY LELTPQTLWT GLPIGNNGTF HTKQDCKIFL SLTRLGPMVH
     GTFMLQAPQY ELTTNGMREI TFSFNSTGGL EQPAPVTYWG ALDPPPTAKA AEIENQKRVK
     KRAAPDPPVE PPPKRRGDLA VLFAKVAEQA MELAKEQAVQ AQPPEHVNTD WADHMNLLRF
     MPNTLVYPTA ATIAANLQFH DTRLSLRRAT LKIRLNGSPD SAYQLGFMLE LVGTQSASIV
     TDTISFWYYA EDY