SPIKE_WBV24
ID SPIKE_WBV24 Reviewed; 1220 AA.
AC Q008X4;
DT 31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 14-NOV-2006, sequence version 1.
DT 25-MAY-2022, entry version 37.
DE RecName: Full=Spike glycoprotein;
DE Short=S glycoprotein;
DE Flags: Precursor;
GN Name=S;
OS White bream virus (isolate Blicca bjoerkna L./Germany/DF24/00) (WBV).
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Nidovirales; Tornidovirineae; Tobaniviridae; Piscanivirinae; Bafinivirus;
OC Blicbavirus.
OX NCBI_TaxID=766180;
OH NCBI_TaxID=58317; Blicca bjoerkna (white bream).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=16987966; DOI=10.1128/jvi.01758-06;
RA Schuetze H., Ulferts R., Schelle B., Bayer S., Granzow H., Hoffmann B.,
RA Mettenleiter T.C., Ziebuhr J.;
RT "Characterization of White bream virus reveals a novel genetic cluster of
RT nidoviruses.";
RL J. Virol. 80:11598-11609(2006).
CC -!- FUNCTION: Mediates the binding of virions to the host cell receptor and
CC is involved in membrane fusion. {ECO:0000250}.
CC -!- SUBUNIT: Homotrimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the torovirinae spike protein family.
CC {ECO:0000305}.
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DR EMBL; DQ898157; ABI97395.1; -; Genomic_RNA.
DR RefSeq; YP_803215.1; NC_008516.1.
DR GeneID; 4443109; -.
DR KEGG; vg:4443109; -.
DR Proteomes; UP000000680; Genome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0039663; P:membrane fusion involved in viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR InterPro; IPR031412; S_torovirinae.
DR Pfam; PF17072; Spike_torovirin; 1.
PE 3: Inferred from homology;
KW Coiled coil; Fusion of virus membrane with host membrane; Glycoprotein;
KW Host-virus interaction; Membrane; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix; Viral attachment to host cell;
KW Viral envelope protein; Viral penetration into host cytoplasm; Virion;
KW Virulence; Virus entry into host cell.
FT SIGNAL 1..15
FT /evidence="ECO:0000255"
FT CHAIN 16..1220
FT /note="Spike glycoprotein"
FT /id="PRO_0000408904"
FT TOPO_DOM 16..1181
FT /note="Virion surface"
FT /evidence="ECO:0000255"
FT TRANSMEM 1182..1202
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1203..1220
FT /note="Intravirion"
FT /evidence="ECO:0000255"
FT COILED 1118..1169
FT /evidence="ECO:0000255"
FT CARBOHYD 60
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 80
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 111
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 262
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 403
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 601
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 644
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 711
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 774
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 789
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 1004
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 1028
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 1091
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 1121
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 1143
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1220 AA; 136440 MW; 10055266F11FDEF8 CRC64;
MWLITILATI SCVTAQLSQT NPDCPIPTCT ILPPPKTTLD NTKFRVVYTK DQEALIYATN
FTSPFNNAQY PLPTLGNHLN RSYTLNYDKV FLNIADSPDM LNLKTSWTVV NNSNLCPLSP
SVYRSTSPLQ TLTTAEQYCF MTTATLTSAF LYDYTAMKPV GYIRARAEET ISFFSIMKTN
MVNRPTSPSL SQAHTHTLAA MRTTATGIQA QTFKPQTGFF IVLDASRARA VTNPLDTAIQ
PKFSPSFIKE VTFDHIFQTT INETARSVTR ETTTGYIMNA AKTGALYKAS PAYYLFLISS
DCRLQQALSV PYDFSLGRFC PASMSCCLNK GYEQYYVNTW LFHYYNLKRL NVLNLESSPV
SDHFIQLHRT FNTEHSMHCD GSPYASDTTY NIALLRDTVQ FLNGTKTTTP LANEIPQLTD
SLGYLKYQPD MVDASDHQNY MAYVTYLMAI FYPTFTEAQK FEFHNLLQSV CYFDKGSISR
NQAYHSICHI ISFQTTASVP YPIELQIPFT TEPTSGYNAY LVKTPIGSVA IGNQNPFDGE
GVCFLTTCIY HPTKKINQKL TIPPVRWQVV PEGIAVVTGI PPNCLGYETY TQGSSFFTIY
NDSKPCQPQT MQIAQARSVI TTVYSAAQKS DIFVQPYGKS SWVNGSYQFD QFVGGALNLR
TLTFTMRKPT QLYVLDPIEG TYIIPDYQTK FPLLTSGTQT YYYDPDQTVT NTTEVSKVTI
DFSIRTMITL DPLVFNCEEF ICDKDPTCRT QFSSYCQTTQ PILAALKDAF EKYNRSIADY
TSTIRALTNT TQDLFASATP VRYRRGVEVP LGYGHDLEQP SWVYDLGGTA IVPWIGTAVA
VGKLANRVAS IEATLYQITQ GVKQSIQSTN DKFDKITNIL HTHLRPVTEG LVRTNEQLNA
FSKQVRDQFT MINTVTTELS AYVDQLQQVF TVGAFYQNQI LQVISQLNSL QVYVDTLTSS
FTDCISDLNQ KILSPACITT HQLLQINKPS DNLGLKNVLT HYINGSAATF YHLTSTKGVY
KPLPKLFNNT HFLAPTTAYN PVTGTCFFCG SNACDKSVTV DCDYQPQPLQ STILAVYPTP
TGLDLLTITS NKTFEIKHGS TVVTSVAIPP PPILSSTINI NVTFQQQLLQ LQEQVDQLNL
QTNYTTTEIQ SIIDKYNVEI QNALNQIVDF GPGTPSLALW KVILILIAVV VVIVIIATTI
FCSVRKNQSE LPLQVLSRLR
