ID   SPIN2_BOVIN             Reviewed;         258 AA.
AC   Q2KI39;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Spindlin-2;
DE   AltName: Full=Spindlin-like protein 2;
DE            Short=SPIN-2;
GN   Name=SPIN2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in the regulation of cell cycle progression.
CC       Exhibits H3K4me3-binding activity. {ECO:0000250|UniProtKB:Q99865}.
CC   -!- SUBUNIT: Interacts with C11orf84/SPINDOC.
CC       {ECO:0000250|UniProtKB:Q99865}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9BPZ2}.
CC   -!- SIMILARITY: Belongs to the SPIN/STSY family. {ECO:0000305}.
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DR   EMBL; BC112780; AAI12781.1; -; mRNA.
DR   RefSeq; NP_001073238.1; NM_001079770.2.
DR   RefSeq; XP_005228298.1; XM_005228241.3.
DR   AlphaFoldDB; Q2KI39; -.
DR   SMR; Q2KI39; -.
DR   STRING; 9913.ENSBTAP00000017636; -.
DR   PaxDb; Q2KI39; -.
DR   PRIDE; Q2KI39; -.
DR   Ensembl; ENSBTAT00000017636; ENSBTAP00000017636; ENSBTAG00000013260.
DR   GeneID; 506451; -.
DR   KEGG; bta:506451; -.
DR   CTD; 506451; -.
DR   VEuPathDB; HostDB:ENSBTAG00000013260; -.
DR   eggNOG; ENOG502QRYD; Eukaryota.
DR   GeneTree; ENSGT00950000182925; -.
DR   HOGENOM; CLU_068595_0_0_1; -.
DR   InParanoid; Q2KI39; -.
DR   OMA; DVHLANT; -.
DR   OrthoDB; 1027563at2759; -.
DR   TreeFam; TF332665; -.
DR   Proteomes; UP000009136; Chromosome X.
DR   Bgee; ENSBTAG00000013260; Expressed in adenohypophysis and 99 other tissues.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR   GO; GO:0035064; F:methylated histone binding; ISS:UniProtKB.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0007276; P:gamete generation; IEA:InterPro.
DR   GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 2.80.10.70; -; 1.
DR   InterPro; IPR029564; SPIN-2.
DR   InterPro; IPR003671; SPIN/Ssty.
DR   InterPro; IPR042567; SPIN/Ssty_sf.
DR   PANTHER; PTHR10405; PTHR10405; 1.
DR   PANTHER; PTHR10405:SF32; PTHR10405:SF32; 1.
DR   Pfam; PF02513; Spin-Ssty; 3.
PE   2: Evidence at transcript level;
KW   Cell cycle; Nucleus; Reference proteome.
FT   CHAIN           1..258
FT                   /note="Spindlin-2"
FT                   /id="PRO_0000259589"
FT   REGION          1..47
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          50..99
FT                   /note="Tudor-like domain 1"
FT                   /evidence="ECO:0000255"
FT   REGION          129..178
FT                   /note="Tudor-like domain 2"
FT                   /evidence="ECO:0000255"
FT   REGION          138
FT                   /note="Histone H3K4me3 and H3R8me2a binding"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y657"
FT   REGION          210..255
FT                   /note="Tudor-like domain 3"
FT                   /evidence="ECO:0000255"
FT   REGION          246..248
FT                   /note="Histone H3K4me3 and H3R8me2a binding"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y657"
FT   COMPBIAS        9..27
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        28..42
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   SITE            169
FT                   /note="Histone H3K4me3 and H3R8me2a binding"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y657"
FT   SITE            176
FT                   /note="Histone H3K4me3 and H3R8me2a binding"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y657"
FT   SITE            180
FT                   /note="Histone H3K4me3 and H3R8me2a binding"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y657"
SQ   SEQUENCE   258 AA;  29807 MW;  6CBB457BF9E9DE99 CRC64;
     MKTPHKKATA RQQTREIVDD HTLSASMRKK KISQKKQRGR PSSQTRRNIV GCRISHGWKE
     GDEPITQWKG TVLDQVPINP SLYLVKYDGI DCVYGLELHR DKRILKLKIL PDKVPFSRVR
     DVHLANTIIG KAVEHMFEGE HGSKDGWRGM VLAQAPIMKA WFYITYEKDP VLYMYQLLDD
     YKEGDLHIMP ESSKSSPKER EPEGVIDGLI GKHVEYTKED GSKRTGKVIH QVKAKPSVYF
     IKFDDDFHIY VYDLVKKS