SPIN3_HUMAN
ID SPIN3_HUMAN Reviewed; 258 AA.
AC Q5JUX0; B2RUW3; B7Z8W2; Q8N5D9;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Spindlin-3;
DE AltName: Full=Spindlin-like protein 3;
DE Short=SPIN-3;
GN Name=SPIN3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain cortex;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN [5]
RP FUNCTION, AND INTERACTION WITH C11ORF84/SPINDOC.
RX PubMed=29061846; DOI=10.1074/jbc.m117.814913;
RA Bae N., Gao M., Li X., Premkumar T., Sbardella G., Chen J., Bedford M.T.;
RT "A transcriptional coregulator, SPIN-DOC, attenuates the coactivator
RT activity of Spindlin1.";
RL J. Biol. Chem. 292:20808-20817(2017).
CC -!- FUNCTION: Exhibits H3K4me3-binding activity.
CC {ECO:0000269|PubMed:29061846}.
CC -!- SUBUNIT: Interacts with C11orf84/SPINDOC (PubMed:29061846).
CC {ECO:0000269|PubMed:29061846}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5JUX0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5JUX0-2; Sequence=VSP_021482, VSP_021483;
CC -!- MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the SPIN/STSY family. {ECO:0000305}.
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DR EMBL; AK304047; BAH14098.1; -; mRNA.
DR EMBL; AL139397; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC018073; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC032490; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC146899; AAI46900.1; -; mRNA.
DR EMBL; BC146906; AAI46907.1; -; mRNA.
DR CCDS; CCDS43963.1; -. [Q5JUX0-1]
DR RefSeq; NP_001010862.2; NM_001010862.2. [Q5JUX0-1]
DR RefSeq; XP_006724640.1; XM_006724577.3. [Q5JUX0-1]
DR RefSeq; XP_006724641.1; XM_006724578.3. [Q5JUX0-1]
DR RefSeq; XP_016884804.1; XM_017029315.1. [Q5JUX0-1]
DR PDB; 5A1H; X-ray; 2.00 A; A/B/C/D=45-258.
DR PDBsum; 5A1H; -.
DR AlphaFoldDB; Q5JUX0; -.
DR SMR; Q5JUX0; -.
DR BioGRID; 127992; 53.
DR IntAct; Q5JUX0; 13.
DR MINT; Q5JUX0; -.
DR STRING; 9606.ENSP00000364054; -.
DR BindingDB; Q5JUX0; -.
DR ChEMBL; CHEMBL4523325; -.
DR iPTMnet; Q5JUX0; -.
DR PhosphoSitePlus; Q5JUX0; -.
DR BioMuta; SPIN3; -.
DR DMDM; 74742352; -.
DR EPD; Q5JUX0; -.
DR jPOST; Q5JUX0; -.
DR MassIVE; Q5JUX0; -.
DR MaxQB; Q5JUX0; -.
DR PaxDb; Q5JUX0; -.
DR PeptideAtlas; Q5JUX0; -.
DR PRIDE; Q5JUX0; -.
DR ProteomicsDB; 63302; -. [Q5JUX0-1]
DR ProteomicsDB; 63303; -. [Q5JUX0-2]
DR Antibodypedia; 432; 56 antibodies from 12 providers.
DR DNASU; 169981; -.
DR Ensembl; ENST00000374919.6; ENSP00000364054.3; ENSG00000204271.13. [Q5JUX0-1]
DR Ensembl; ENST00000475785.7; ENSP00000436805.1; ENSG00000204271.13. [Q5JUX0-2]
DR Ensembl; ENST00000478405.1; ENSP00000433337.1; ENSG00000204271.13. [Q5JUX0-2]
DR Ensembl; ENST00000638257.1; ENSP00000492795.1; ENSG00000204271.13. [Q5JUX0-1]
DR Ensembl; ENST00000638289.1; ENSP00000491751.1; ENSG00000204271.13. [Q5JUX0-1]
DR Ensembl; ENST00000638386.1; ENSP00000491624.1; ENSG00000204271.13. [Q5JUX0-1]
DR Ensembl; ENST00000638664.1; ENSP00000492829.1; ENSG00000204271.13. [Q5JUX0-2]
DR Ensembl; ENST00000638712.1; ENSP00000492344.1; ENSG00000204271.13. [Q5JUX0-1]
DR Ensembl; ENST00000638819.1; ENSP00000491334.1; ENSG00000204271.13. [Q5JUX0-2]
DR Ensembl; ENST00000638834.1; ENSP00000492685.1; ENSG00000204271.13. [Q5JUX0-2]
DR Ensembl; ENST00000638873.1; ENSP00000492648.1; ENSG00000204271.13. [Q5JUX0-2]
DR Ensembl; ENST00000638940.1; ENSP00000491878.1; ENSG00000204271.13. [Q5JUX0-2]
DR Ensembl; ENST00000639000.1; ENSP00000491947.1; ENSG00000204271.13. [Q5JUX0-2]
DR Ensembl; ENST00000639007.1; ENSP00000492381.1; ENSG00000204271.13. [Q5JUX0-1]
DR Ensembl; ENST00000639053.1; ENSP00000491667.1; ENSG00000204271.13. [Q5JUX0-2]
DR Ensembl; ENST00000639257.1; ENSP00000492259.1; ENSG00000204271.13. [Q5JUX0-2]
DR Ensembl; ENST00000639418.1; ENSP00000491050.1; ENSG00000204271.13. [Q5JUX0-2]
DR Ensembl; ENST00000639482.1; ENSP00000491221.1; ENSG00000204271.13. [Q5JUX0-2]
DR Ensembl; ENST00000639605.1; ENSP00000491179.1; ENSG00000204271.13. [Q5JUX0-1]
DR Ensembl; ENST00000639607.1; ENSP00000492130.1; ENSG00000204271.13. [Q5JUX0-2]
DR Ensembl; ENST00000639794.1; ENSP00000491103.1; ENSG00000204271.13. [Q5JUX0-2]
DR Ensembl; ENST00000639809.1; ENSP00000491646.1; ENSG00000204271.13. [Q5JUX0-2]
DR Ensembl; ENST00000639888.1; ENSP00000491629.1; ENSG00000204271.13. [Q5JUX0-2]
DR Ensembl; ENST00000639895.1; ENSP00000491610.1; ENSG00000204271.13. [Q5JUX0-2]
DR Ensembl; ENST00000639956.1; ENSP00000491098.1; ENSG00000204271.13. [Q5JUX0-2]
DR Ensembl; ENST00000640039.1; ENSP00000491607.1; ENSG00000204271.13. [Q5JUX0-2]
DR Ensembl; ENST00000640101.1; ENSP00000492502.1; ENSG00000204271.13. [Q5JUX0-2]
DR Ensembl; ENST00000640104.1; ENSP00000491400.1; ENSG00000204271.13. [Q5JUX0-2]
DR Ensembl; ENST00000640131.1; ENSP00000491666.1; ENSG00000204271.13. [Q5JUX0-2]
DR Ensembl; ENST00000640187.1; ENSP00000492486.1; ENSG00000204271.13. [Q5JUX0-2]
DR Ensembl; ENST00000640421.1; ENSP00000491130.1; ENSG00000204271.13. [Q5JUX0-2]
DR Ensembl; ENST00000640463.1; ENSP00000491882.1; ENSG00000204271.13. [Q5JUX0-2]
DR Ensembl; ENST00000640507.1; ENSP00000492445.1; ENSG00000204271.13. [Q5JUX0-2]
DR Ensembl; ENST00000640511.1; ENSP00000491321.1; ENSG00000204271.13. [Q5JUX0-2]
DR Ensembl; ENST00000640577.1; ENSP00000492824.1; ENSG00000204271.13. [Q5JUX0-2]
DR Ensembl; ENST00000640717.1; ENSP00000491217.1; ENSG00000204271.13. [Q5JUX0-2]
DR Ensembl; ENST00000640728.1; ENSP00000492383.1; ENSG00000204271.13. [Q5JUX0-2]
DR GeneID; 169981; -.
DR KEGG; hsa:169981; -.
DR MANE-Select; ENST00000374919.6; ENSP00000364054.3; NM_001010862.3; NP_001010862.2.
DR UCSC; uc004dux.2; human. [Q5JUX0-1]
DR CTD; 169981; -.
DR DisGeNET; 169981; -.
DR GeneCards; SPIN3; -.
DR HGNC; HGNC:27272; SPIN3.
DR HPA; ENSG00000204271; Low tissue specificity.
DR neXtProt; NX_Q5JUX0; -.
DR OpenTargets; ENSG00000204271; -.
DR PharmGKB; PA134909757; -.
DR VEuPathDB; HostDB:ENSG00000204271; -.
DR eggNOG; ENOG502QRYD; Eukaryota.
DR GeneTree; ENSGT00950000182925; -.
DR HOGENOM; CLU_068595_2_0_1; -.
DR InParanoid; Q5JUX0; -.
DR OMA; HLAEIMI; -.
DR OrthoDB; 1027563at2759; -.
DR PhylomeDB; Q5JUX0; -.
DR TreeFam; TF332665; -.
DR PathwayCommons; Q5JUX0; -.
DR SignaLink; Q5JUX0; -.
DR BioGRID-ORCS; 169981; 18 hits in 707 CRISPR screens.
DR ChiTaRS; SPIN3; human.
DR GenomeRNAi; 169981; -.
DR Pharos; Q5JUX0; Tchem.
DR PRO; PR:Q5JUX0; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q5JUX0; protein.
DR Bgee; ENSG00000204271; Expressed in secondary oocyte and 144 other tissues.
DR ExpressionAtlas; Q5JUX0; baseline and differential.
DR Genevisible; Q5JUX0; HS.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR GO; GO:0035064; F:methylated histone binding; IDA:UniProtKB.
DR GO; GO:0007276; P:gamete generation; IEA:InterPro.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR Gene3D; 2.80.10.70; -; 1.
DR InterPro; IPR003671; SPIN/Ssty.
DR InterPro; IPR042567; SPIN/Ssty_sf.
DR InterPro; IPR029567; Spindlin-3.
DR PANTHER; PTHR10405; PTHR10405; 1.
DR PANTHER; PTHR10405:SF18; PTHR10405:SF18; 1.
DR Pfam; PF02513; Spin-Ssty; 3.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Reference proteome.
FT CHAIN 1..258
FT /note="Spindlin-3"
FT /id="PRO_0000259591"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 50..99
FT /note="Tudor-like domain 1"
FT /evidence="ECO:0000255"
FT REGION 129..178
FT /note="Tudor-like domain 2"
FT /evidence="ECO:0000255"
FT REGION 138
FT /note="Histone H3K4me3 and H3R8me2a binding"
FT /evidence="ECO:0000250|UniProtKB:Q9Y657"
FT REGION 210..255
FT /note="Tudor-like domain 3"
FT /evidence="ECO:0000255"
FT REGION 246..248
FT /note="Histone H3K4me3 and H3R8me2a binding"
FT /evidence="ECO:0000250|UniProtKB:Q9Y657"
FT SITE 169
FT /note="Histone H3K4me3 and H3R8me2a binding"
FT /evidence="ECO:0000250|UniProtKB:Q9Y657"
FT SITE 176
FT /note="Histone H3K4me3 and H3R8me2a binding"
FT /evidence="ECO:0000250|UniProtKB:Q9Y657"
FT SITE 180
FT /note="Histone H3K4me3 and H3R8me2a binding"
FT /evidence="ECO:0000250|UniProtKB:Q9Y657"
FT VAR_SEQ 76..77
FT /note="VP -> LL (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_021482"
FT VAR_SEQ 78..258
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_021483"
FT CONFLICT 4
FT /note="P -> A (in Ref. 1; BAH14098)"
FT /evidence="ECO:0000305"
FT STRAND 53..58
FT /evidence="ECO:0007829|PDB:5A1H"
FT STRAND 66..75
FT /evidence="ECO:0007829|PDB:5A1H"
FT STRAND 83..87
FT /evidence="ECO:0007829|PDB:5A1H"
FT STRAND 94..96
FT /evidence="ECO:0007829|PDB:5A1H"
FT TURN 98..100
FT /evidence="ECO:0007829|PDB:5A1H"
FT STRAND 104..109
FT /evidence="ECO:0007829|PDB:5A1H"
FT HELIX 123..128
FT /evidence="ECO:0007829|PDB:5A1H"
FT STRAND 132..138
FT /evidence="ECO:0007829|PDB:5A1H"
FT STRAND 144..154
FT /evidence="ECO:0007829|PDB:5A1H"
FT STRAND 156..158
FT /evidence="ECO:0007829|PDB:5A1H"
FT STRAND 162..166
FT /evidence="ECO:0007829|PDB:5A1H"
FT STRAND 169..175
FT /evidence="ECO:0007829|PDB:5A1H"
FT HELIX 177..183
FT /evidence="ECO:0007829|PDB:5A1H"
FT STRAND 186..188
FT /evidence="ECO:0007829|PDB:5A1H"
FT STRAND 213..217
FT /evidence="ECO:0007829|PDB:5A1H"
FT STRAND 223..231
FT /evidence="ECO:0007829|PDB:5A1H"
FT STRAND 238..243
FT /evidence="ECO:0007829|PDB:5A1H"
FT STRAND 250..253
FT /evidence="ECO:0007829|PDB:5A1H"
SQ SEQUENCE 258 AA; 29207 MW; 431F7EB61F5FBA81 CRC64;
MKTPFGKAAA GQRSRTGAGH GSVSVTMIKR KAAHKKHRSR PTSQPRGNIV GCRIQHGWKD
GDEPLTQWKG TVLDQVPVNP SLYLIKYDGF DCVYGLELHR DERVSSLEVL PNRVASSRIS
DTHLAEIMVG KAVEHIFETE EGSKNEWRGM VLAQAPVMNT WFYITYEKDP VLYMYQLLDD
YKDGDLRILQ DSNDSPLAER EPGEVIDSLV GKQVEYAKDD GSKRTGMVIH QVEAKPSVYF
IKFDDDFHIY VYDLVKTS
