ID   SPIN3_PONAB             Reviewed;         258 AA.
AC   Q5RAW7; H2PVT5;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2017, sequence version 2.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Spindlin-3;
DE   AltName: Full=Spindlin-like protein 3;
DE            Short=SPIN-3;
GN   Name=SPIN3;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Wilson R.K., Mardis E.;
RT   "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-77.
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Exhibits H3K4me3-binding activity.
CC       {ECO:0000250|UniProtKB:Q5JUX0}.
CC   -!- SUBUNIT: Interacts with C11orf84/SPINDOC.
CC       {ECO:0000250|UniProtKB:Q5JUX0}.
CC   -!- SIMILARITY: Belongs to the SPIN/STSY family. {ECO:0000305}.
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DR   EMBL; ABGA01017836; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CR858894; CAH91093.1; -; mRNA.
DR   RefSeq; NP_001125637.1; NM_001132165.1.
DR   AlphaFoldDB; Q5RAW7; -.
DR   SMR; Q5RAW7; -.
DR   STRING; 9601.ENSPPYP00000022837; -.
DR   Ensembl; ENSPPYT00000037538; ENSPPYP00000031536; ENSPPYG00000034066.
DR   GeneID; 100172555; -.
DR   KEGG; pon:100172555; -.
DR   CTD; 169981; -.
DR   eggNOG; ENOG502QRYD; Eukaryota.
DR   GeneTree; ENSGT00950000182925; -.
DR   InParanoid; Q5RAW7; -.
DR   OMA; HLAEIMI; -.
DR   TreeFam; TF332665; -.
DR   Proteomes; UP000001595; Chromosome X.
DR   GO; GO:0035064; F:methylated histone binding; ISS:UniProtKB.
DR   GO; GO:0007276; P:gamete generation; IEA:InterPro.
DR   Gene3D; 2.80.10.70; -; 1.
DR   InterPro; IPR003671; SPIN/Ssty.
DR   InterPro; IPR042567; SPIN/Ssty_sf.
DR   InterPro; IPR029567; Spindlin-3.
DR   PANTHER; PTHR10405; PTHR10405; 1.
DR   PANTHER; PTHR10405:SF18; PTHR10405:SF18; 1.
DR   Pfam; PF02513; Spin-Ssty; 3.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..258
FT                   /note="Spindlin-3"
FT                   /id="PRO_0000259592"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          50..99
FT                   /note="Tudor-like domain 1"
FT                   /evidence="ECO:0000255"
FT   REGION          129..178
FT                   /note="Tudor-like domain 2"
FT                   /evidence="ECO:0000255"
FT   REGION          138
FT                   /note="Histone H3K4me3 and H3R8me2a binding"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y657"
FT   REGION          210..255
FT                   /note="Tudor-like domain 3"
FT                   /evidence="ECO:0000255"
FT   REGION          246..248
FT                   /note="Histone H3K4me3 and H3R8me2a binding"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y657"
FT   SITE            169
FT                   /note="Histone H3K4me3 and H3R8me2a binding"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y657"
FT   SITE            176
FT                   /note="Histone H3K4me3 and H3R8me2a binding"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y657"
FT   SITE            180
FT                   /note="Histone H3K4me3 and H3R8me2a binding"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y657"
FT   CONFLICT        15
FT                   /note="R -> G (in Ref. 2; CAH91093)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        76..77
FT                   /note="VP -> LL (in Ref. 2; CAH91093)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   258 AA;  29306 MW;  4BA05FE811A44E2A CRC64;
     MKTPFGKAAA GQRSRTGAGH GSVSVTMIKR KAAHKKHRSR PTSQPRRNIV GCRIQHGWKD
     GDEPLTQWKG TVLDQVPVNP SLYLIKYDGF DCVYGLELHR DERVSSLEVL PNRVASSRIS
     DTHLAEIMVG KAVEHIFETE EGSKNEWRGM VLAQAPVMNT WFYITYEKDP VLYMYQLLDD
     YKDGDLRILQ DSNDSPLAER EPGEVIDSLV GKQVEYAKDD GSKRTGMVIH QVEAKPSVYF
     IKFDDDFHIY VYDLVKTS