SPIN4_MOUSE
ID SPIN4_MOUSE Reviewed; 249 AA.
AC Q8K1L2; Q8BXD0;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Spindlin-4;
GN Name=Spin4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Cerebellum, and Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Exhibits H3K4me3-binding activity.
CC {ECO:0000250|UniProtKB:Q56A73}.
CC -!- SUBUNIT: Interacts with C11orf84/SPINDOC.
CC {ECO:0000250|UniProtKB:Q56A73}.
CC -!- SIMILARITY: Belongs to the SPIN/STSY family. {ECO:0000305}.
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DR EMBL; AK036158; BAC29325.1; -; mRNA.
DR EMBL; AK043030; BAC31440.1; -; mRNA.
DR EMBL; AK047896; BAC33186.1; -; mRNA.
DR EMBL; AK147852; BAE28181.1; -; mRNA.
DR EMBL; AK155170; BAE33091.1; -; mRNA.
DR EMBL; BX470092; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC027796; AAH27796.1; -; mRNA.
DR CCDS; CCDS30282.1; -.
DR RefSeq; NP_848868.1; NM_178753.4.
DR AlphaFoldDB; Q8K1L2; -.
DR SMR; Q8K1L2; -.
DR STRING; 10090.ENSMUSP00000094095; -.
DR PhosphoSitePlus; Q8K1L2; -.
DR EPD; Q8K1L2; -.
DR MaxQB; Q8K1L2; -.
DR PaxDb; Q8K1L2; -.
DR PeptideAtlas; Q8K1L2; -.
DR PRIDE; Q8K1L2; -.
DR ProteomicsDB; 258721; -.
DR Antibodypedia; 52266; 79 antibodies from 13 providers.
DR DNASU; 270624; -.
DR Ensembl; ENSMUST00000096367; ENSMUSP00000094095; ENSMUSG00000071722.
DR GeneID; 270624; -.
DR KEGG; mmu:270624; -.
DR UCSC; uc009tts.2; mouse.
DR CTD; 139886; -.
DR MGI; MGI:2444925; Spin4.
DR VEuPathDB; HostDB:ENSMUSG00000071722; -.
DR eggNOG; ENOG502QRYD; Eukaryota.
DR GeneTree; ENSGT00950000182925; -.
DR HOGENOM; CLU_068595_0_0_1; -.
DR InParanoid; Q8K1L2; -.
DR OMA; HGRKDEW; -.
DR OrthoDB; 1027563at2759; -.
DR PhylomeDB; Q8K1L2; -.
DR TreeFam; TF332665; -.
DR BioGRID-ORCS; 270624; 2 hits in 71 CRISPR screens.
DR PRO; PR:Q8K1L2; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q8K1L2; protein.
DR Bgee; ENSMUSG00000071722; Expressed in vas deferens and 138 other tissues.
DR Genevisible; Q8K1L2; MM.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR GO; GO:0035064; F:methylated histone binding; ISS:UniProtKB.
DR GO; GO:0007276; P:gamete generation; IEA:InterPro.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR Gene3D; 2.80.10.70; -; 1.
DR InterPro; IPR003671; SPIN/Ssty.
DR InterPro; IPR042567; SPIN/Ssty_sf.
DR InterPro; IPR029578; Spindlin-4.
DR PANTHER; PTHR10405; PTHR10405; 1.
DR PANTHER; PTHR10405:SF9; PTHR10405:SF9; 1.
DR Pfam; PF02513; Spin-Ssty; 3.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..249
FT /note="Spindlin-4"
FT /id="PRO_0000313795"
FT REGION 41..90
FT /note="Tudor-like domain 1"
FT /evidence="ECO:0000255"
FT REGION 80..85
FT /note="Histone H3K4me3 and H3R8me2a binding"
FT /evidence="ECO:0000250|UniProtKB:Q9Y657"
FT REGION 119..168
FT /note="Tudor-like domain 2"
FT /evidence="ECO:0000255"
FT REGION 128
FT /note="Histone H3K4me3 and H3R8me2a binding"
FT /evidence="ECO:0000250|UniProtKB:Q9Y657"
FT REGION 201..246
FT /note="Tudor-like domain 3"
FT /evidence="ECO:0000255"
FT REGION 237..239
FT /note="Histone H3K4me3 and H3R8me2a binding"
FT /evidence="ECO:0000250|UniProtKB:Q9Y657"
FT SITE 159
FT /note="Histone H3K4me3 and H3R8me2a binding"
FT /evidence="ECO:0000250|UniProtKB:Q9Y657"
FT SITE 170
FT /note="Histone H3K4me3 and H3R8me2a binding"
FT /evidence="ECO:0000250|UniProtKB:Q9Y657"
FT CONFLICT 41
FT /note="V -> G (in Ref. 1; BAC33186)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 249 AA; 28508 MW; 0B0485959A4A2F10 CRC64;
MSPPTVPPTG VDGVSAYLMK KRHTHKKQRR KPTFLTHRNI VGCRIQHGWK EGNEPVEQWK
GTVLEQVSVK PTLYIIKYDG KDSVYGLELH RDKRVLALEI LPERVPSPRI DSRLADSLVG
KAVGHVFEGE HGKKDEWKGM VLARAPIMDT WFYITYEKDP VLYMYTLLDD YKDGDLRIIP
DSNYYFPAAE QEPGEVLDSL VGKQVEHAKD DGSKRTGIFI HQVVAKPSVY FIKFDDDIHI
YVYGLVKTP
