SPJ1_SCHPO
ID SPJ1_SCHPO Reviewed; 381 AA.
AC O94625; Q9Y8G9;
DT 06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2002, sequence version 2.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=DnaJ-related protein spj1;
GN Name=spj1; ORFNames=SPBC1347.05c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Kawamukai M.;
RT "S.pombe dnaJ homolog.";
RL Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [3]
RP REVISION OF GENE MODEL.
RX PubMed=21511999; DOI=10.1126/science.1203357;
RA Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT "Comparative functional genomics of the fission yeasts.";
RL Science 332:930-936(2011).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB37436.3; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB029547; BAA82347.1; -; mRNA.
DR EMBL; CU329671; CAB37436.3; ALT_SEQ; Genomic_DNA.
DR PIR; T39393; T39393.
DR PIR; T43517; T43517.
DR RefSeq; NP_596697.3; NM_001022621.2.
DR AlphaFoldDB; O94625; -.
DR SMR; O94625; -.
DR STRING; 4896.SPBC1347.05c.1; -.
DR MaxQB; O94625; -.
DR PaxDb; O94625; -.
DR GeneID; 2540021; -.
DR KEGG; spo:SPBC1347.05c; -.
DR PomBase; SPBC1347.05c; -.
DR eggNOG; KOG0712; Eukaryota.
DR HOGENOM; CLU_017633_0_2_1; -.
DR InParanoid; O94625; -.
DR PhylomeDB; O94625; -.
DR PRO; PR:O94625; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005788; C:endoplasmic reticulum lumen; ISO:PomBase.
DR GO; GO:0051087; F:chaperone binding; IBA:GO_Central.
DR GO; GO:0030544; F:Hsp70 protein binding; ISM:PomBase.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR GO; GO:0034620; P:cellular response to unfolded protein; ISO:PomBase.
DR GO; GO:0034975; P:protein folding in endoplasmic reticulum; ISO:PomBase.
DR GO; GO:0042026; P:protein refolding; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; ISO:PomBase.
DR CDD; cd06257; DnaJ; 1.
DR CDD; cd10719; DnaJ_zf; 1.
DR Gene3D; 1.10.287.110; -; 1.
DR InterPro; IPR002939; DnaJ_C.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR018253; DnaJ_domain_CS.
DR InterPro; IPR044713; DNJA1/2-like.
DR InterPro; IPR008971; HSP40/DnaJ_pept-bd.
DR InterPro; IPR001305; HSP_DnaJ_Cys-rich_dom.
DR InterPro; IPR036410; HSP_DnaJ_Cys-rich_dom_sf.
DR InterPro; IPR036869; J_dom_sf.
DR PANTHER; PTHR43888; PTHR43888; 1.
DR Pfam; PF00226; DnaJ; 1.
DR Pfam; PF01556; DnaJ_C; 1.
DR Pfam; PF00684; DnaJ_CXXCXGXG; 1.
DR PRINTS; PR00625; JDOMAIN.
DR SMART; SM00271; DnaJ; 1.
DR SUPFAM; SSF46565; SSF46565; 1.
DR SUPFAM; SSF49493; SSF49493; 2.
DR SUPFAM; SSF57938; SSF57938; 1.
DR PROSITE; PS00636; DNAJ_1; 1.
DR PROSITE; PS50076; DNAJ_2; 1.
DR PROSITE; PS51188; ZF_CR; 1.
PE 2: Evidence at transcript level;
KW Chaperone; Endoplasmic reticulum; Metal-binding; Protein transport;
KW Reference proteome; Repeat; Transport; Zinc; Zinc-finger.
FT CHAIN 1..381
FT /note="DnaJ-related protein spj1"
FT /id="PRO_0000071092"
FT DOMAIN 5..74
FT /note="J"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00286"
FT REPEAT 151..158
FT /note="CXXCXGXG motif"
FT REPEAT 172..179
FT /note="CXXCXGXG motif"
FT REPEAT 199..206
FT /note="CXXCXGXG motif"
FT REPEAT 213..220
FT /note="CXXCXGXG motif"
FT ZN_FING 138..225
FT /note="CR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00546"
FT REGION 72..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 378..381
FT /note="Prevents secretion from ER"
FT /evidence="ECO:0000255"
SQ SEQUENCE 381 AA; 42384 MW; 8D60C754B8A80B2B CRC64;
MFTNNFSQKQ ILGVSKDASE SEIRKAYRQL TKQWHPDKNP GNEEAQEKFI EINKAHEVLS
DPEQRKIYDA YGEEGLNGQP GGPGGGPGEG FPGGGFGFDP FGDIFDNIFG GRRRQNAVRR
GPSMEQIVQI HLSSFYTGGS FTLEIPVKRT CSVCSGQGFN PKYSADKAIE SCPVCGGSGF
RVIEHMIAPG FRQQMRMPCN ACNGNGRTIK HKCPRCKGER VAEVVESFDI KVPAGAPEGY
RIGFRGKADE IPGMEAGDII VILEAAGGDY GWTRKDNDLY RKETISVREA LLGNWKRKIQ
KLDGSFMEVK RSAGEVVHPG ETERVKNQGM PIYNLHKGKT TSAHGSAYIE WEVKFPKKLK
GKFLKDLNNL FEKYDNEFDE L
