SPL2B_BOVIN
ID SPL2B_BOVIN Reviewed; 240 AA.
AC P79125;
DT 29-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 25-MAY-2022, entry version 88.
DE RecName: Full=Short palate, lung and nasal epithelium carcinoma-associated protein 2B;
DE AltName: Full=BSP30b;
DE AltName: Full=Common salivary protein form b;
DE Flags: Precursor;
GN Name=SPLUNC2B; Synonyms=BSP30B;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Holstein-Friesian; TISSUE=Parotid gland;
RX PubMed=12427544; DOI=10.1016/s0167-4781(02)00508-0;
RA Wheeler T.T., Haigh B.J., McCracken J.Y., Wilkins R.J., Morris C.A.,
RA Grigor M.R.;
RT "The BSP30 salivary proteins from cattle, LUNX/PLUNC and von Ebner's minor
RT salivary gland protein are members of the PSP/LBP superfamily of
RT proteins.";
RL Biochim. Biophys. Acta 1579:92-100(2002).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Parotid glands.
CC -!- SIMILARITY: Belongs to the BPI/LBP/Plunc superfamily. Plunc family.
CC {ECO:0000305}.
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DR EMBL; U79414; AAB38283.1; -; mRNA.
DR RefSeq; NP_777227.1; NM_174802.2.
DR PDB; 5WD6; X-ray; 2.00 A; A/B=20-240.
DR PDB; 6O1T; X-ray; 2.30 A; A/B=29-229.
DR PDBsum; 5WD6; -.
DR PDBsum; 6O1T; -.
DR AlphaFoldDB; P79125; -.
DR SMR; P79125; -.
DR STRING; 9913.ENSBTAP00000026321; -.
DR PaxDb; P79125; -.
DR GeneID; 286881; -.
DR KEGG; bta:286881; -.
DR CTD; 286881; -.
DR eggNOG; ENOG502TE6F; Eukaryota.
DR InParanoid; P79125; -.
DR OrthoDB; 1389938at2759; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0030141; C:secretory granule; IBA:GO_Central.
DR GO; GO:0001530; F:lipopolysaccharide binding; IBA:GO_Central.
DR InterPro; IPR017943; Bactericidal_perm-incr_a/b_dom.
DR InterPro; IPR017942; Lipid-bd_serum_glycop_N.
DR Pfam; PF01273; LBP_BPI_CETP; 1.
DR SUPFAM; SSF55394; SSF55394; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Disulfide bond; Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..240
FT /note="Short palate, lung and nasal epithelium carcinoma-
FT associated protein 2B"
FT /id="PRO_0000017183"
FT DISULFID 163..206
FT /evidence="ECO:0000250"
FT HELIX 31..39
FT /evidence="ECO:0007829|PDB:5WD6"
FT HELIX 41..44
FT /evidence="ECO:0007829|PDB:5WD6"
FT HELIX 47..60
FT /evidence="ECO:0007829|PDB:5WD6"
FT TURN 61..63
FT /evidence="ECO:0007829|PDB:5WD6"
FT HELIX 72..91
FT /evidence="ECO:0007829|PDB:5WD6"
FT STRAND 92..100
FT /evidence="ECO:0007829|PDB:5WD6"
FT STRAND 105..110
FT /evidence="ECO:0007829|PDB:5WD6"
FT STRAND 113..128
FT /evidence="ECO:0007829|PDB:5WD6"
FT TURN 129..131
FT /evidence="ECO:0007829|PDB:5WD6"
FT STRAND 132..149
FT /evidence="ECO:0007829|PDB:5WD6"
FT STRAND 158..163
FT /evidence="ECO:0007829|PDB:5WD6"
FT HELIX 167..169
FT /evidence="ECO:0007829|PDB:5WD6"
FT STRAND 170..176
FT /evidence="ECO:0007829|PDB:5WD6"
FT HELIX 184..203
FT /evidence="ECO:0007829|PDB:5WD6"
FT HELIX 205..214
FT /evidence="ECO:0007829|PDB:5WD6"
FT HELIX 218..227
FT /evidence="ECO:0007829|PDB:5WD6"
SQ SEQUENCE 240 AA; 26513 MW; 850611DE9E43E358 CRC64;
MVQLWKLVLL CGLLAGTSAS LPDIRGNDVL RKLKSGLERG LDTFDSTIEI IFQNLKTELE
SRCSDEVVEQ QETENFLEQL ISRIFQVVSR LTGVRIRNVQ VPDITFEATS ENSANVLIPI
TADVTVSLPF LGEIVDLDLN VDLQTTVSIE TDTEDPQVVV GECTNNPESI SLTVLHSRFG
LVNDVVDIGV NLARRVVSSV VEGELCPRFR ELLESLDAEC VEKLIGESQD TTQQEPEGSR
