SPLA_STAA1
ID SPLA_STAA1 Reviewed; 235 AA.
AC A7X3R0;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 1.
DT 03-AUG-2022, entry version 69.
DE RecName: Full=Serine protease SplA;
DE EC=3.4.21.-;
DE Flags: Precursor;
GN Name=splA; OrderedLocusNames=SAHV_1798;
OS Staphylococcus aureus (strain Mu3 / ATCC 700698).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=418127;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Mu3 / ATCC 700698;
RX PubMed=17954695; DOI=10.1128/aac.00534-07;
RA Neoh H.-M., Cui L., Yuzawa H., Takeuchi F., Matsuo M., Hiramatsu K.;
RT "Mutated response regulator graR is responsible for phenotypic conversion
RT of Staphylococcus aureus from heterogeneous vancomycin-intermediate
RT resistance to vancomycin-intermediate resistance.";
RL Antimicrob. Agents Chemother. 52:45-53(2008).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the peptidase S1B family. {ECO:0000305}.
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DR EMBL; AP009324; BAF78681.1; -; Genomic_DNA.
DR RefSeq; WP_001039427.1; NC_009782.1.
DR AlphaFoldDB; A7X3R0; -.
DR SMR; A7X3R0; -.
DR MEROPS; S01.503; -.
DR KEGG; saw:SAHV_1798; -.
DR HOGENOM; CLU_073589_2_0_9; -.
DR OMA; NAQFEVV; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 2.40.10.10; -; 2.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR008256; Peptidase_S1B.
DR InterPro; IPR008353; Peptidase_S1B_tx.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR028301; V8_his_AS.
DR Pfam; PF00089; Trypsin; 1.
DR PRINTS; PR01774; EXFOLTOXIN.
DR PRINTS; PR00839; V8PROTEASE.
DR SUPFAM; SSF50494; SSF50494; 1.
DR PROSITE; PS00672; V8_HIS; 1.
PE 3: Inferred from homology;
KW Hydrolase; Protease; Secreted; Serine protease; Signal.
FT SIGNAL 1..35
FT /evidence="ECO:0000250"
FT CHAIN 36..235
FT /note="Serine protease SplA"
FT /id="PRO_0000359529"
FT ACT_SITE 74
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT ACT_SITE 113
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT ACT_SITE 189
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
SQ SEQUENCE 235 AA; 25441 MW; DE576B839B4A8682 CRC64;
MNKNVMVKGL TALTILTSLG FAENISNQPH SIAKAEKNVK EITDATKAPY NSVVAFAGGT
GVVVGKNTIV TNKHIAKSND IFKNRVAAHY SSKGKGGGNY DVKDIVEYPG KEDLAIVHVH
ETSTEGLNFN KNVSYTKFAE GAKAKDRISV IGYPKGAQTK YKMFESTGTI NHISGTFIEF
DAYAQPGNSG SPVLNSKHEL IGILYAGSGK DESEKNFGVY FTPQLKEFIQ NNIEK