SPLA_STAA3
ID SPLA_STAA3 Reviewed; 235 AA.
AC Q2FFS9;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2006, sequence version 1.
DT 03-AUG-2022, entry version 69.
DE RecName: Full=Serine protease SplA;
DE EC=3.4.21.-;
DE Flags: Precursor;
GN Name=splA; OrderedLocusNames=SAUSA300_1758;
OS Staphylococcus aureus (strain USA300).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=367830;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=USA300;
RX PubMed=16517273; DOI=10.1016/s0140-6736(06)68231-7;
RA Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G.,
RA Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F.,
RA Perdreau-Remington F.;
RT "Complete genome sequence of USA300, an epidemic clone of community-
RT acquired meticillin-resistant Staphylococcus aureus.";
RL Lancet 367:731-739(2006).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the peptidase S1B family. {ECO:0000305}.
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DR EMBL; CP000255; ABD21885.1; -; Genomic_DNA.
DR RefSeq; WP_001039435.1; NZ_CP027476.1.
DR AlphaFoldDB; Q2FFS9; -.
DR SMR; Q2FFS9; -.
DR MEROPS; S01.503; -.
DR PRIDE; Q2FFS9; -.
DR EnsemblBacteria; ABD21885; ABD21885; SAUSA300_1758.
DR KEGG; saa:SAUSA300_1758; -.
DR HOGENOM; CLU_073589_2_0_9; -.
DR OMA; NAQFEVV; -.
DR Proteomes; UP000001939; Chromosome.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 2.40.10.10; -; 2.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR008256; Peptidase_S1B.
DR InterPro; IPR008353; Peptidase_S1B_tx.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR028301; V8_his_AS.
DR Pfam; PF00089; Trypsin; 1.
DR PRINTS; PR01774; EXFOLTOXIN.
DR PRINTS; PR00839; V8PROTEASE.
DR SUPFAM; SSF50494; SSF50494; 1.
DR PROSITE; PS00672; V8_HIS; 1.
PE 3: Inferred from homology;
KW Hydrolase; Protease; Secreted; Serine protease; Signal.
FT SIGNAL 1..35
FT /evidence="ECO:0000250"
FT CHAIN 36..235
FT /note="Serine protease SplA"
FT /id="PRO_0000359536"
FT ACT_SITE 74
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT ACT_SITE 113
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT ACT_SITE 189
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
SQ SEQUENCE 235 AA; 25549 MW; DBC6B23C6648BCF9 CRC64;
MNKNVMVKGL TALTILTSLG FAENISNQPH SIAKAEKNVK EITDATKEPY NSVVAFVGGT
GVVVGKNTIV TNKHIAKSND IFKNRVSAHH SSKGKGGGNY DVKDIVEYPG KEDLAIVHVH
ETSTEGLNFN KNVSYTKFAD GAKVKDRISV IGYPKGAQTK YKMFESTGTI NHISGTFMEF
DAYAQPGNSG SPVLNSKHEL IGILYAGSGK DESEKNFGVY FTPQLKEFIQ NNIEK