ID   SPLC_STAAU              Reviewed;         239 AA.
AC   Q53782;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Serine protease SplC;
DE            EC=3.4.21.-;
DE   Flags: Precursor;
GN   Name=splC;
OS   Staphylococcus aureus.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=1280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=FDA 485;
RX   PubMed=9048880; DOI=10.1016/s0167-4781(96)00216-3;
RA   Rieneck K., Renneberg J., Diamant M., Gutschik E., Bendtzen K.;
RT   "Molecular cloning and expression of a novel Staphylococcus aureus
RT   antigen.";
RL   Biochim. Biophys. Acta 1350:128-132(1997).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase S1B family. {ECO:0000305}.
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DR   EMBL; U63529; AAC12901.1; -; Genomic_DNA.
DR   RefSeq; WP_001038872.1; NZ_WYDB01000002.1.
DR   PDB; 2AS9; X-ray; 1.70 A; A/B=37-239.
DR   PDBsum; 2AS9; -.
DR   AlphaFoldDB; Q53782; -.
DR   SMR; Q53782; -.
DR   MEROPS; S01.283; -.
DR   OMA; DYPGNED; -.
DR   EvolutionaryTrace; Q53782; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.10.10; -; 2.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR   InterPro; IPR008256; Peptidase_S1B.
DR   InterPro; IPR008353; Peptidase_S1B_tx.
DR   InterPro; IPR001254; Trypsin_dom.
DR   InterPro; IPR028301; V8_his_AS.
DR   Pfam; PF00089; Trypsin; 1.
DR   PRINTS; PR01774; EXFOLTOXIN.
DR   PRINTS; PR00839; V8PROTEASE.
DR   SUPFAM; SSF50494; SSF50494; 1.
DR   PROSITE; PS00672; V8_HIS; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Hydrolase; Protease; Secreted; Serine protease; Signal.
FT   SIGNAL          1..36
FT                   /evidence="ECO:0000250"
FT   CHAIN           37..239
FT                   /note="Serine protease SplC"
FT                   /id="PRO_0000359551"
FT   ACT_SITE        75
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        113
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        193
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   239 AA;  26099 MW;  A56BB3CDB77B29A9 CRC64;
     MNKNIVIKSM AALAILTSVT GINAAVVEET QQIANAEKNV TQVKDTNNFP YNGVVSFKDA
     TGFVIGKNTI ITNKHVSKDY KVGDRITAHP NGDKGNGGIY KIKSISDYPG DEDISVMNIE
     EQAVERGPKG FNFNENVQAF NFAKDAKVDD KIKVIGYPLP AQNSFKQFES TGTIKRIKDN
     ILNFDAYIEP GNSGSPVLNS NNEVIGVVYG GIGKIGSEYN GAVYFTPQIK DFIQKHIEQ