ID   SPN1_CHICK              Reviewed;         365 AA.
AC   Q5ZI43;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Snurportin-1;
DE   AltName: Full=RNA U transporter 1;
GN   Name=SNUPN; Synonyms=RNUT1; ORFNames=RCJMB04_30h8;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Functions as an U snRNP-specific nuclear import adapter.
CC       Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import
CC       of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.
CC       {ECO:0000250|UniProtKB:O95149}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O95149}. Cytoplasm
CC       {ECO:0000250|UniProtKB:O95149}. Note=Nucleoplasmic shuttling protein.
CC       {ECO:0000250|UniProtKB:O95149}.
CC   -!- SIMILARITY: Belongs to the snurportin family. {ECO:0000305}.
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DR   EMBL; AJ720941; CAG32600.1; -; mRNA.
DR   RefSeq; NP_001074347.1; NM_001080878.1.
DR   AlphaFoldDB; Q5ZI43; -.
DR   SMR; Q5ZI43; -.
DR   STRING; 9031.ENSGALP00000041377; -.
DR   GeneID; 770225; -.
DR   KEGG; gga:770225; -.
DR   CTD; 10073; -.
DR   VEuPathDB; HostDB:geneid_770225; -.
DR   eggNOG; KOG3132; Eukaryota.
DR   InParanoid; Q5ZI43; -.
DR   OrthoDB; 1342398at2759; -.
DR   PhylomeDB; Q5ZI43; -.
DR   PRO; PR:Q5ZI43; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042564; C:NLS-dependent protein nuclear import complex; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0061608; F:nuclear import signal receptor activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR   GO; GO:0061015; P:snRNA import into nucleus; IEA:InterPro.
DR   InterPro; IPR002652; Importin-a_IBB.
DR   InterPro; IPR017336; Snurportin-1.
DR   InterPro; IPR024721; Snurportin-1_N.
DR   PANTHER; PTHR13403; PTHR13403; 1.
DR   Pfam; PF11538; Snurportin1; 1.
DR   PIRSF; PIRSF037955; Snurportin-1; 1.
DR   PROSITE; PS51214; IBB; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; RNA-binding; Transport.
FT   CHAIN           1..365
FT                   /note="Snurportin-1"
FT                   /id="PRO_0000191074"
FT   DOMAIN          10..72
FT                   /note="IBB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00561"
FT   REGION          15..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          69..90
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          129..131
FT                   /note="Interaction with m3G-cap structure"
FT                   /evidence="ECO:0000250|UniProtKB:O95149"
FT   REGION          211..333
FT                   /note="Necessary for binding to the m3G-cap structure"
FT                   /evidence="ECO:0000250|UniProtKB:O95149"
FT   REGION          317..365
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        71..87
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        345..365
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   SITE            107
FT                   /note="Interaction with m3G-cap structure"
FT                   /evidence="ECO:0000250|UniProtKB:O95149"
FT   SITE            146
FT                   /note="Interaction with m3G-cap structure"
FT                   /evidence="ECO:0000250|UniProtKB:O95149"
FT   SITE            279
FT                   /note="Interaction with m3G-cap structure"
FT                   /evidence="ECO:0000250|UniProtKB:O95149"
SQ   SEQUENCE   365 AA;  40742 MW;  39F5572397E47C77 CRC64;
     MEELCAALAG GVALAAPNSP AAPHPRLSAY KGRGDRLGQA ERRRRLLCLQ RERRLDYVNH
     ARRLAEGDWA GVESDEDGGE DGDGEEEMEV DAGRRLPKRY ANQLMLSEWL VDVPVDLEQE
     WIVVVCPVGK RALVVASRGS TAAYTKSGFC VNRFPSLLPG GNRHNTMNEK VYCILDCIYN
     EAEQTYYILD VMCWRGHPVY DCQTDFRFFW LSSKIQEEEG LGEKSRINPY KFVGLQNFPC
     TSESLCEVLT TNFPFEVDGL LFYHKQTHYT PGSTPLVGWL RPYMVPDILG LTVPATPLTA
     KPDYAGRQLQ QIIESKRSKK LAAGKAQPSA EAAARNGHYE LEHLSTPQPA NSAQGQEEAG
     SQMEN