SPN1_DROME
ID SPN1_DROME Reviewed; 351 AA.
AC B7Z0I7;
DT 06-JUL-2016, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 1.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=Snurportin-1 {ECO:0000305|PubMed:23885126};
GN Name=Snup {ECO:0000312|FlyBase:FBgn0259199};
GN ORFNames=CG42303 {ECO:0000312|FlyBase:FBgn0259199};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000312|Proteomes:UP000000803};
RN [1] {ECO:0000312|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000312|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3] {ECO:0000305}
RP INTERACTION WITH MSK; SMB AND SMN, SUBCELLULAR LOCATION, AND DEVELOPMENTAL
RP STAGE.
RX PubMed=23885126; DOI=10.1091/mbc.e13-03-0118;
RA Natalizio A.H., Matera A.G.;
RT "Identification and characterization of Drosophila Snurportin reveals a
RT role for the import receptor Moleskin/Importin7 in snRNP biogenesis.";
RL Mol. Biol. Cell 24:2932-2942(2013).
CC -!- FUNCTION: Functions as an U snRNP-specific nuclear import adapter.
CC Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import
CC of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.
CC {ECO:0000250|UniProtKB:O95149}.
CC -!- SUBUNIT: Interacts with components of the snRNP complex including SmB
CC and Smn; these interactions are RNA-dependent. Interacts with importin-
CC 7 msk but not with importin subunit beta Fs(2)Ket; the interaction is
CC RNA-dependent. {ECO:0000269|PubMed:23885126}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23885126}. Cytoplasm
CC {ECO:0000269|PubMed:23885126}. Nucleus speckle
CC {ECO:0000269|PubMed:23885126}. Nucleus, Cajal body
CC {ECO:0000269|PubMed:23885126}. Note=Mostly localized to the nuclear
CC periphery. In Malpighian tubule cells, detected in nuclear foci that
CC include the Cajal bodies. Accumulates in the U bodies of the follicle
CC and nurse cells. {ECO:0000269|PubMed:23885126}.
CC -!- DEVELOPMENTAL STAGE: Expressed throughout development and in adults,
CC with highest levels of expression during embryogenesis.
CC {ECO:0000269|PubMed:23885126}.
CC -!- SIMILARITY: Belongs to the snurportin family. {ECO:0000305}.
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DR EMBL; AE014296; ACL83233.1; -; Genomic_DNA.
DR RefSeq; NP_001137877.1; NM_001144405.3.
DR AlphaFoldDB; B7Z0I7; -.
DR SMR; B7Z0I7; -.
DR STRING; 7227.FBpp0288961; -.
DR PaxDb; B7Z0I7; -.
DR EnsemblMetazoa; FBtr0299683; FBpp0288961; FBgn0259199.
DR GeneID; 7354429; -.
DR KEGG; dme:Dmel_CG42303; -.
DR CTD; 7354429; -.
DR FlyBase; FBgn0259199; Snup.
DR VEuPathDB; VectorBase:FBgn0259199; -.
DR eggNOG; KOG3132; Eukaryota.
DR GeneTree; ENSGT00510000047494; -.
DR HOGENOM; CLU_056809_0_0_1; -.
DR OMA; KRSQEGM; -.
DR PhylomeDB; B7Z0I7; -.
DR BioGRID-ORCS; 7354429; 1 hit in 1 CRISPR screen.
DR GenomeRNAi; 7354429; -.
DR PRO; PR:B7Z0I7; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0259199; Expressed in ovary and 6 other tissues.
DR Genevisible; B7Z0I7; DM.
DR GO; GO:0015030; C:Cajal body; IDA:FlyBase.
DR GO; GO:0071254; C:cytoplasmic U snRNP body; IDA:FlyBase.
DR GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR GO; GO:0030619; F:U1 snRNA binding; IDA:FlyBase.
DR GO; GO:0030620; F:U2 snRNA binding; IDA:FlyBase.
DR GO; GO:0030621; F:U4 snRNA binding; IDA:FlyBase.
DR GO; GO:0061015; P:snRNA import into nucleus; IEA:InterPro.
DR InterPro; IPR017336; Snurportin-1.
DR PANTHER; PTHR13403; PTHR13403; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Cytoplasm; Nucleus; Reference proteome; RNA-binding;
KW Transport.
FT CHAIN 1..351
FT /note="Snurportin-1"
FT /evidence="ECO:0000305"
FT /id="PRO_0000436527"
FT REGION 1..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 294..322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 274..330
FT /evidence="ECO:0000255"
FT COMPBIAS 13..54
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 294..310
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 351 AA; 41504 MW; 701326BCB160BE82 CRC64;
MESSFQELYK KGLDIGEQQK QRQKELLKQQ KLRRQQEQDD YRPLQNQEKP VPRKKSGKRS
GHQKGIPYRP QLSEWLRHKP DDLNEWLLVP CPVGKRCLVV ASKGITKAYS KGGWMFVNFR
SSLPGDWQLQ KGETILDCVY VEDADTFYVL DAISFGLQEV QECEASFRFY WLRARFEEHD
YDKISENNEK KFKLLDHFDF EDPSAVEQAL HKYPFFPENK PDLDGFLFYH KEASYVCRET
PLVCWLFPFM MEDVLGLPVN KCYKAPEDYQ PSHVLQYMDA FEQKLAEHRR TLKEQKKKVN
EQKEDPHTME AEEDVESDEY DSLKRVLDQQ RRLELGEFDM DCAEPPSADG C
