ID   SPNS1_BOVIN             Reviewed;         528 AA.
AC   Q08DX7;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Protein spinster homolog 1;
GN   Name=SPNS1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal pons;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Sphingolipid transporter. May be involved in necrotic or
CC       autophagic cell death (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with BCL2 and BCL2L1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Spinster (TC
CC       2.A.1.49) family. {ECO:0000305}.
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DR   EMBL; BT030723; ABS45039.1; -; mRNA.
DR   EMBL; BC123522; AAI23523.1; -; mRNA.
DR   RefSeq; NP_001070276.1; NM_001076808.2.
DR   AlphaFoldDB; Q08DX7; -.
DR   SMR; Q08DX7; -.
DR   STRING; 9913.ENSBTAP00000019510; -.
DR   PaxDb; Q08DX7; -.
DR   PRIDE; Q08DX7; -.
DR   Ensembl; ENSBTAT00000019510; ENSBTAP00000019510; ENSBTAG00000014653.
DR   GeneID; 505997; -.
DR   KEGG; bta:505997; -.
DR   CTD; 83985; -.
DR   VEuPathDB; HostDB:ENSBTAG00000014653; -.
DR   eggNOG; KOG1330; Eukaryota.
DR   GeneTree; ENSGT00390000005976; -.
DR   HOGENOM; CLU_001265_5_12_1; -.
DR   InParanoid; Q08DX7; -.
DR   OMA; DQMVMSP; -.
DR   OrthoDB; 891881at2759; -.
DR   TreeFam; TF314395; -.
DR   Proteomes; UP000009136; Chromosome 25.
DR   Bgee; ENSBTAG00000014653; Expressed in conceptus and 104 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   CDD; cd17328; MFS_spinster_like; 1.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR044770; MFS_spinster-like.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   PANTHER; PTHR23505; PTHR23505; 1.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   2: Evidence at transcript level;
KW   Lipid transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..528
FT                   /note="Protein spinster homolog 1"
FT                   /id="PRO_0000305038"
FT   TRANSMEM        50..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        98..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        126..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        160..180
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        187..207
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        218..238
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        278..298
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        323..343
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        357..377
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        381..401
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        421..441
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        465..485
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..44
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         518
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H2V7"
SQ   SEQUENCE   528 AA;  56519 MW;  1DF9FB8825E04C47 CRC64;
     MSGSDTAPFL SQADDTDDGP APGTPGLPGS MGNPKSEDPA VPDQEGLQRI TGLSSGHSAL
     IVAVLCYINL LNYMDRFTVA GVLPDIEQFF DIGDGSSGLI QTVFISSYMV LAPVFGYLGD
     RYNRKYLMCG GIAFWSLVTL GSSFIPRERF WLLLLTRGLV GVGEASYSTI APTLIADLFV
     ADQRSRMLSV FYFAIPVGSG LGYIAGSKVK DVAGDWHWAL RVTPGLGVLA VVLLFLVVQE
     PPRGAVERHS DSPPLNPTSW WADLRALARN PSFILSSLGF TAVAFVTGSL ALWAPAFLLR
     SRVVLGETPP CLPGDSCSSS DSLIFGLITC LTGVLGVGLG VEISRRLRRT NPRADPLVCA
     AGLLGSAPFL FLALACARGS IVATYIFIFI GETLLSMNWA IVADILLYVV IPTRRSTAEA
     FQIVLSHLLG DAGSPYLIGS ISDRLRRDWP PSFLSEFRAL QFSLMLCAFV GALGGAAFLG
     TAIFIESDRR QAQLHVQGLL PETGPTDDRI VVPQRGRSTR VPVSSVLI