ID   SPNS1_XENLA             Reviewed;         526 AA.
AC   Q5XGK0;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Protein spinster homolog 1;
GN   Name=spns1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Sphingolipid transporter. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Spinster (TC
CC       2.A.1.49) family. {ECO:0000305}.
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DR   EMBL; BC084438; AAH84438.1; -; mRNA.
DR   RefSeq; NP_001088358.1; NM_001094889.1.
DR   AlphaFoldDB; Q5XGK0; -.
DR   SMR; Q5XGK0; -.
DR   DNASU; 495202; -.
DR   GeneID; 495202; -.
DR   KEGG; xla:495202; -.
DR   CTD; 495202; -.
DR   Xenbase; XB-GENE-959723; spns1.L.
DR   OrthoDB; 891881at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 495202; Expressed in testis and 20 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   CDD; cd17328; MFS_spinster_like; 1.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR044770; MFS_spinster-like.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   PANTHER; PTHR23505; PTHR23505; 1.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   2: Evidence at transcript level;
KW   Lipid transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..526
FT                   /note="Protein spinster homolog 1"
FT                   /id="PRO_0000305042"
FT   TRANSMEM        59..79
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        98..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        126..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        159..179
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        187..207
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        218..238
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        272..292
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        321..341
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        355..375
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        384..404
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        419..439
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        463..483
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..44
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..18
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   526 AA;  57806 MW;  C36588C0CB6865D3 CRC64;
     MTSRRSHGDV TPFLTQADNT EEEGVRDPES QSSDEEEEEG KDHGKETHLL TGISYKRSVI
     IVIILFYINL LNYMDRFTVA GVLPDIKKAF NISDSNSGLV QTVFICSYMF LAPVFGYLGD
     RYNRKLIMCV GISFWSLVTL LSSFVSNQYF WLFLITRGLV GVGEASYSTI APTIIADLFL
     ADQRTRMLSF FYFATPVGCG LGYIVGSEMT SAAGDWHWAL RVTPGLGLLA VLLLIFVAEE
     PPRGALERKT DRPLTNTSWS SDMKALLKNP SFILSTFGFT TVAFVTGALA LWGPTYLMRS
     RMVIYKSKPC EGGICNYDDS MIFGGITCIT GILGVLTGVE ISKRYRKTNP RADPLVCAVG
     MISSAPFLFL SLAFADTSLV ATYVFIFIGE TLLSLNWALV ADILLYVVIP TRRSTAEALQ
     IVVSHLLGDA GSPYLIGVIS DQIQKGKPAS FLIQMRSLEY ALMICAFVGV IGGGFFLTTA
     LFIEKDRKKA ELFSQGLLPA DETDAERIVV PKRGRSTKVP VSSVLI