ID   SPNS1_XENTR             Reviewed;         526 AA.
AC   A8WGF7;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 2.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Protein spinster homolog 1;
GN   Name=spns1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Sphingolipid transporter. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=A8WGF7-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=A8WGF7-2; Sequence=VSP_036365;
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Spinster (TC
CC       2.A.1.49) family. {ECO:0000305}.
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DR   EMBL; BC154692; AAI54693.1; -; mRNA.
DR   RefSeq; NP_001106495.1; NM_001113024.1. [A8WGF7-2]
DR   AlphaFoldDB; A8WGF7; -.
DR   SMR; A8WGF7; -.
DR   PaxDb; A8WGF7; -.
DR   DNASU; 100127684; -.
DR   GeneID; 100127684; -.
DR   KEGG; xtr:100127684; -.
DR   CTD; 83985; -.
DR   Xenbase; XB-GENE-959720; spns1.
DR   eggNOG; KOG1330; Eukaryota.
DR   InParanoid; A8WGF7; -.
DR   OrthoDB; 891881at2759; -.
DR   Proteomes; UP000008143; Chromosome 9.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   CDD; cd17328; MFS_spinster_like; 1.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR044770; MFS_spinster-like.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   PANTHER; PTHR23505; PTHR23505; 1.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Lipid transport; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..526
FT                   /note="Protein spinster homolog 1"
FT                   /id="PRO_0000363953"
FT   TRANSMEM        48..68
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        98..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        126..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        159..179
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        187..207
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        218..238
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        272..292
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        321..341
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        355..375
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        385..405
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        419..439
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        463..483
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        24..43
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         439..526
FT                   /note="ISDQIQKGKAPSFLIQMRSLEYALMICAFVGVIGGGFFLATALFIEKDRKRA
FT                   ELFSQGLLPADETDAERIVVPKRGRSTKVPVSSVLI -> VSRGPPAVG (in
FT                   isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_036365"
SQ   SEQUENCE   526 AA;  57510 MW;  ECD582DE993D255A CRC64;
     MTSRSSQGDA APFLTQADNT EEEGAPDPGG HSSDEEEEEG KDHGKEAHLL TGISYRHSVT
     IVIILFYINL LNYMDRFTVA GVLSDIKEDY HISDSNSGLV QTVFICSYMF LAPVFGYLGD
     RYNRKLIMCI GISFWSLVTL LSSFVSKQYF WLFLLTRGLV GVGEASYSTI APTIIADLFL
     ADQRSRMLSF FYFATPVGCG LGYIAGSKVT STAGDWHWAL RVTPGLGLVA VLLLIFVAKE
     PPRGALERKS DRPLTNTSWF SDVKALLKNP SFILSTFGFT TVAFVTGALA LWGPTYLMRS
     RRVIYKTEPC QGGICNYDDS MIFGGITCVT GVLGVLTGVE ISKRYRKTNP RADPLVCAVG
     MISSAPFLYL SLAFADTSLV ATYAFIFIGE TLLSLNWALV ADILLYVVIP TRRSTAEALQ
     IVVSHLLGDA GSPYLIGVIS DQIQKGKAPS FLIQMRSLEY ALMICAFVGV IGGGFFLATA
     LFIEKDRKRA ELFSQGLLPA DETDAERIVV PKRGRSTKVP VSSVLI