SPNS3_ARATH
ID SPNS3_ARATH Reviewed; 510 AA.
AC F4IKF6; Q9ZQ41;
DT 25-JAN-2012, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 62.
DE RecName: Full=Probable sphingolipid transporter spinster homolog 3;
GN OrderedLocusNames=At2g22730; ORFNames=T9I22.17;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- FUNCTION: Probable sphingolipid transporter. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=F4IKF6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=F4IKF6-2; Sequence=VSP_042228;
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Spinster (TC
CC 2.A.1.49) family. {ECO:0000305}.
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DR EMBL; AC006340; AAD15581.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC07346.1; -; Genomic_DNA.
DR EMBL; CP002685; ANM62554.1; -; Genomic_DNA.
DR PIR; B84616; B84616.
DR RefSeq; NP_001324703.1; NM_001335818.1. [F4IKF6-2]
DR RefSeq; NP_179858.2; NM_127838.3. [F4IKF6-1]
DR AlphaFoldDB; F4IKF6; -.
DR SMR; F4IKF6; -.
DR STRING; 3702.AT2G22730.1; -.
DR TCDB; 2.A.1.49.3; the major facilitator superfamily (mfs).
DR PaxDb; F4IKF6; -.
DR PRIDE; F4IKF6; -.
DR EnsemblPlants; AT2G22730.1; AT2G22730.1; AT2G22730. [F4IKF6-1]
DR EnsemblPlants; AT2G22730.6; AT2G22730.6; AT2G22730. [F4IKF6-2]
DR GeneID; 816803; -.
DR Gramene; AT2G22730.1; AT2G22730.1; AT2G22730. [F4IKF6-1]
DR Gramene; AT2G22730.6; AT2G22730.6; AT2G22730. [F4IKF6-2]
DR KEGG; ath:AT2G22730; -.
DR Araport; AT2G22730; -.
DR TAIR; locus:2066045; AT2G22730.
DR eggNOG; KOG1330; Eukaryota.
DR HOGENOM; CLU_001265_55_3_1; -.
DR InParanoid; F4IKF6; -.
DR PRO; PR:F4IKF6; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; F4IKF6; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR CDD; cd17328; MFS_spinster_like; 1.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR044770; MFS_spinster-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR23505; PTHR23505; 1.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Glycoprotein; Lipid transport; Membrane;
KW Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..510
FT /note="Probable sphingolipid transporter spinster homolog
FT 3"
FT /id="PRO_0000415371"
FT TRANSMEM 44..64
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 106..126
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 136..156
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 158..178
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 185..205
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 219..239
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 298..318
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 336..356
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 369..387
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 392..414
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 430..450
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 462..482
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 75
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 98
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 479..510
FT /note="KINLNSFYSNDESFLVQIKLFVANLCFCKGYS -> IFINSVDRFNQEETGS
FT ENPRRPELSSRTP (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_042228"
SQ SEQUENCE 510 AA; 55667 MW; 90BA57046049B7CD CRC64;
MVTKEEDCLP PVTETTSRCY STSSSTPLAE LETVRSLEIV ESSSSLSPVW LLVIFCIINL
LNYMDRGAIA SNGVNGSTRS CNDKGKCTLA TGIQGHFNLS NFEDGVLSSS FMVGLLIASP
IFASLAKRLI GVGLTVWTIA VLGCGSSFAF WFIVLCRMFV GVGEASFISL AAPFIDDNAP
QEQKAAWLGL FYMCIPSGVA LGYVYGGYVG KHFSWRYAFW GEAVLMAPFA VLGFLMKPLQ
LKGSETLKNN NRLQVDNEIE HDQFEVSIET SKSSYANAVF KSFTGFAKDM KVLYKEKVFV
VNVLGYVSYN FVIGAYSYWG PKAGYNIYKM KNADMIFGAV TIICGIVGTL SGGFILDRVT
ATIPNAFKLL SGATFLGAVF CFTAFTLKSL YGFIALFALG ELLVFATQAP VNYVCLHCVK
PSLRPLSMAI STVAIHIFGD VPSSPLVGIV QDHINSWRKT TLILTSILFL AAAIWFIGKI
NLNSFYSNDE SFLVQIKLFV ANLCFCKGYS
