ID   SPNS3_DANRE             Reviewed;         498 AA.
AC   A2CER7; A2SWM3;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Protein spinster homolog 3;
DE   AltName: Full=Spinster-like protein 3;
GN   Name=spns3; Synonyms=spinl3; ORFNames=si:ch211-117m20.8;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 98-498.
RX   PubMed=19062281; DOI=10.1016/j.cub.2008.10.061;
RA   Osborne N., Brand-Arzamendi K., Ober E.A., Jin S.-W., Verkade H.,
RA   Holtzman N.G., Yelon D., Stainier D.Y.R.;
RT   "The spinster homolog, two of hearts, is required for sphingosine 1-
RT   phosphate signaling in zebrafish.";
RL   Curr. Biol. 18:1882-1888(2008).
CC   -!- FUNCTION: Sphingolipid transporter. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Spinster (TC
CC       2.A.1.49) family. {ECO:0000305}.
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DR   EMBL; CR753844; CAM15238.1; -; Genomic_DNA.
DR   EMBL; DQ360112; ABC88834.1; -; mRNA.
DR   RefSeq; NP_001093506.1; NM_001100036.1.
DR   RefSeq; XP_009299816.1; XM_009301541.1.
DR   RefSeq; XP_009299817.1; XM_009301542.2.
DR   RefSeq; XP_017211639.1; XM_017356150.1.
DR   RefSeq; XP_017211640.1; XM_017356151.1.
DR   AlphaFoldDB; A2CER7; -.
DR   SMR; A2CER7; -.
DR   STRING; 7955.ENSDARP00000051391; -.
DR   PaxDb; A2CER7; -.
DR   Ensembl; ENSDART00000051392; ENSDARP00000051391; ENSDARG00000035459.
DR   Ensembl; ENSDART00000127787; ENSDARP00000110713; ENSDARG00000035459.
DR   Ensembl; ENSDART00000182367; ENSDARP00000145247; ENSDARG00000035459.
DR   Ensembl; ENSDART00000188528; ENSDARP00000150728; ENSDARG00000115176.
DR   GeneID; 568387; -.
DR   KEGG; dre:568387; -.
DR   CTD; 201305; -.
DR   ZFIN; ZDB-GENE-060531-7; spns3.
DR   eggNOG; KOG1330; Eukaryota.
DR   GeneTree; ENSGT00390000005976; -.
DR   InParanoid; A2CER7; -.
DR   OMA; WHWAFRI; -.
DR   OrthoDB; 891881at2759; -.
DR   PhylomeDB; A2CER7; -.
DR   PRO; PR:A2CER7; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 5.
DR   Bgee; ENSDARG00000035459; Expressed in granulocyte and 16 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   CDD; cd17328; MFS_spinster_like; 1.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR044770; MFS_spinster-like.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   PANTHER; PTHR23505; PTHR23505; 1.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   2: Evidence at transcript level;
KW   Lipid transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..498
FT                   /note="Protein spinster homolog 3"
FT                   /id="PRO_0000305048"
FT   TRANSMEM        49..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        114..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        148..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        175..195
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        207..227
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        260..280
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        309..329
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        343..363
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        373..393
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        407..427
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        451..471
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   498 AA;  54289 MW;  47AC44BCBC2DE615 CRC64;
     MASDQHRPKP RLSLRSSTTI RYGSMSSEHP DGDPSTPQTT SISQRRSYIA VAVLCYINLL
     NYMDRYTIAG VLLRIQKFFF ISDSTSGLLQ TVFICSFMFL APVFGYLGDR YDRKLIMIVG
     LVMWIVTTLG SSFVRKSHFW VLVATRALVG TGEASYSTIA PTIIGDLFAG SKRTLMISFF
     YIFIPVGSGL GYIIGATVAD ATGDWRWALR VSPALGGLGL LLLVFLIPNP PRGASDNGGA
     NMETTSYTED IKYLLKNRSF VWSSLGVTAM AFVTGALAFW TPTFLSRAQV TQGLKQPCKE
     EPCDSVDSYI FGAITVVTGV VGVFLGTCIS KKLRDRVPNA DPLICAVGML SSSPCFFIAI
     VLASTSIPAT YTFIAIGETL LSLNWAILAD ILLYVVVPNR RATAEALQIM VCHLLGDAGS
     PYLIGAISDS LSKYNTTDPS WDFRRLEYSV LLCPFIGVLG GLFFLMTSLY IKEDRKAAEL
     LTSGQTPQPE ITTVSESV