SPNXA_HUMAN
ID SPNXA_HUMAN Reviewed; 97 AA.
AC Q9NS26; Q5JWI0;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Sperm protein associated with the nucleus on the X chromosome A {ECO:0000305};
DE AltName: Full=Cancer/testis antigen 11.1;
DE Short=CT11.1 {ECO:0000312|HGNC:HGNC:11218};
DE AltName: Full=Nuclear-associated protein SPAN-Xa {ECO:0000312|EMBL:AAF28420.1};
DE Short=SPAN-X;
DE Short=SPANX-A;
DE AltName: Full=SPANX family member A;
GN Name=SPANXA1 {ECO:0000312|HGNC:HGNC:11218}; Synonyms=SPANXA;
GN and
GN Name=SPANXA2 {ECO:0000312|HGNC:HGNC:14328};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, TISSUE SPECIFICITY, AND
RP SUBCELLULAR LOCATION.
RC TISSUE=Testis;
RX PubMed=10906052; DOI=10.1093/biolreprod/63.2.469;
RA Westbrook V.A., Diekman A.B., Klotz K.L., Khole V.V., von Kap-Herr C.,
RA Golden W.L., Eddy R.L., Shows T.B., Stoler M.H., Lee C.-G.,
RA Flickinger C.J., Herr J.C.;
RT "Spermatid-specific expression of the novel X-linked gene product SPAN-X
RT localized to the nucleus of human spermatozoa.";
RL Biol. Reprod. 63:469-481(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], DEVELOPMENTAL STAGE, AND TISSUE
RP SPECIFICITY.
RX PubMed=12758128; DOI=10.1016/s0378-1119(03)00497-9;
RA Zendman A.J., Zschocke J., van Kraats A.A., de Wit N.J.W., Kurpisz M.,
RA Weidle U.H., Ruiter D.J., Weiss E.H., van Muijen G.N.P.;
RT "The human SPANX multigene family: genomic organization, alignment and
RT expression in male germ cells and tumor cell lines.";
RL Gene 309:125-133(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=16251457; DOI=10.1101/gr.4212705;
RA Kouprina N., Pavlicek A., Noskov V.N., Solomon G., Otstot J., Isaacs W.,
RA Carpten J.D., Trent J.M., Schleutker J., Barrett J.C., Jurka J.,
RA Larionov V.;
RT "Dynamic structure of the SPANX gene cluster mapped to the prostate cancer
RT susceptibility locus HPCX at Xq27.";
RL Genome Res. 15:1477-1486(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=17373721; DOI=10.1002/pros.20561;
RA Kouprina N., Noskov V.N., Solomon G., Otstot J., Isaacs W., Xu J.,
RA Schleutker J., Larionov V.;
RT "Mutational analysis of SPANX genes in families with X-linked prostate
RT cancer.";
RL Prostate 67:820-828(2007).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q9NS26; A0A0C4DGQ7: EML2; NbExp=3; IntAct=EBI-10313181, EBI-12112376;
CC Q9NS26; Q9Y6X0: SETBP1; NbExp=3; IntAct=EBI-10313181, EBI-2548259;
CC Q9NS26; Q9Y6X0-2: SETBP1; NbExp=3; IntAct=EBI-10313181, EBI-12235818;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10906052}. Nucleus
CC {ECO:0000269|PubMed:10906052}. Note=Associated with nuclear craters.
CC -!- TISSUE SPECIFICITY: Detected in testis and sperm.
CC {ECO:0000269|PubMed:10906052, ECO:0000269|PubMed:12758128}.
CC -!- DEVELOPMENTAL STAGE: Detected in round and elongating spermatids.
CC {ECO:0000269|PubMed:10906052, ECO:0000269|PubMed:12758128}.
CC -!- SIMILARITY: Belongs to the SPAN-X family. {ECO:0000305}.
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DR EMBL; AF098306; AAF28420.1; -; mRNA.
DR EMBL; AJ457794; CAD29843.1; -; Genomic_DNA.
DR EMBL; AY920732; AAY16548.1; -; mRNA.
DR EMBL; AY920733; AAY16549.1; -; mRNA.
DR EMBL; AY920735; AAY16551.1; -; mRNA.
DR EMBL; AY920736; AAY16552.1; -; mRNA.
DR EMBL; AY920738; AAY16554.1; -; mRNA.
DR EMBL; AY920739; AAY16555.1; -; mRNA.
DR EMBL; AY920741; AAY16557.1; -; mRNA.
DR EMBL; AY920742; AAY16558.1; -; mRNA.
DR EMBL; AY920743; AAY16559.1; -; mRNA.
DR EMBL; AY920744; AAY16560.1; -; mRNA.
DR EMBL; AY920745; AAY16561.1; -; mRNA.
DR EMBL; AY920746; AAY16562.1; -; mRNA.
DR EMBL; DQ994201; ABN68940.1; -; Genomic_DNA.
DR EMBL; DQ994202; ABN68941.1; -; Genomic_DNA.
DR EMBL; DQ994203; ABN68942.1; -; Genomic_DNA.
DR EMBL; DQ994204; ABN68943.1; -; Genomic_DNA.
DR EMBL; DQ994205; ABN68944.1; -; Genomic_DNA.
DR EMBL; DQ994206; ABN68945.1; -; Genomic_DNA.
DR EMBL; DQ994207; ABN68946.1; -; Genomic_DNA.
DR EMBL; DQ994208; ABN68947.1; -; Genomic_DNA.
DR EMBL; DQ994209; ABN68948.1; -; Genomic_DNA.
DR EMBL; DQ994210; ABN68949.1; -; Genomic_DNA.
DR EMBL; AL121881; CAD19068.1; -; Genomic_DNA.
DR EMBL; AL121881; CAI42369.1; -; Genomic_DNA.
DR EMBL; BC069393; AAH69393.1; -; mRNA.
DR EMBL; BC069816; AAH69816.1; -; mRNA.
DR CCDS; CCDS14674.1; -.
DR CCDS; CCDS44007.1; -.
DR RefSeq; NP_038481.2; NM_013453.3.
DR RefSeq; NP_663695.1; NM_145662.3.
DR AlphaFoldDB; Q9NS26; -.
DR BioGRID; 119032; 9.
DR BioGRID; 609133; 10.
DR IntAct; Q9NS26; 7.
DR MINT; Q9NS26; -.
DR STRING; 9606.ENSP00000359549; -.
DR iPTMnet; Q9NS26; -.
DR PhosphoSitePlus; Q9NS26; -.
DR BioMuta; SPANXA1; -.
DR DMDM; 77416663; -.
DR MassIVE; Q9NS26; -.
DR MaxQB; Q9NS26; -.
DR PaxDb; Q9NS26; -.
DR PeptideAtlas; Q9NS26; -.
DR PRIDE; Q9NS26; -.
DR ProteomicsDB; 82474; -.
DR Antibodypedia; 71820; 18 antibodies from 6 providers.
DR Antibodypedia; 74669; 18 antibodies from 5 providers.
DR DNASU; 30014; -.
DR Ensembl; ENST00000370518.4; ENSP00000359549.3; ENSG00000203926.5.
DR Ensembl; ENST00000370519.3; ENSP00000359550.3; ENSG00000198021.7.
DR GeneID; 30014; -.
DR GeneID; 728712; -.
DR KEGG; hsa:30014; -.
DR KEGG; hsa:728712; -.
DR MANE-Select; ENST00000370518.4; ENSP00000359549.3; NM_145662.4; NP_663695.1.
DR MANE-Select; ENST00000370519.4; ENSP00000359550.3; NM_013453.3; NP_038481.2.
DR UCSC; uc004fbn.4; human.
DR CTD; 30014; -.
DR CTD; 728712; -.
DR DisGeNET; 30014; -.
DR DisGeNET; 728712; -.
DR GeneCards; SPANXA1; -.
DR GeneCards; SPANXA2; -.
DR HGNC; HGNC:11218; SPANXA1.
DR HGNC; HGNC:14328; SPANXA2.
DR HPA; ENSG00000198021; Tissue enriched (testis).
DR HPA; ENSG00000203926; Tissue enriched (testis).
DR MIM; 300305; gene.
DR MIM; 300493; gene.
DR neXtProt; NX_Q9NS26; -.
DR OpenTargets; ENSG00000198021; -.
DR PharmGKB; PA37870; -.
DR VEuPathDB; HostDB:ENSG00000198021; -.
DR VEuPathDB; HostDB:ENSG00000203926; -.
DR eggNOG; ENOG502TEHU; Eukaryota.
DR GeneTree; ENSGT00730000111796; -.
DR HOGENOM; CLU_140435_1_0_1; -.
DR InParanoid; Q9NS26; -.
DR OMA; DETMPET; -.
DR OrthoDB; 1820184at2759; -.
DR PhylomeDB; Q9NS26; -.
DR TreeFam; TF341404; -.
DR PathwayCommons; Q9NS26; -.
DR SignaLink; Q9NS26; -.
DR BioGRID-ORCS; 30014; 13 hits in 219 CRISPR screens.
DR BioGRID-ORCS; 728712; 58 hits in 566 CRISPR screens.
DR Pharos; Q9NS26; Tbio.
DR PRO; PR:Q9NS26; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q9NS26; protein.
DR Bgee; ENSG00000198021; Expressed in left testis and 8 other tissues.
DR Genevisible; Q9NS26; HS.
DR GO; GO:0005737; C:cytoplasm; TAS:ProtInc.
DR GO; GO:0005634; C:nucleus; HDA:UniProtKB.
DR GO; GO:0007283; P:spermatogenesis; TAS:ProtInc.
DR InterPro; IPR010007; SPAN-X_fam.
DR PANTHER; PTHR23425; PTHR23425; 1.
DR Pfam; PF07458; SPAN-X; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Nucleus; Reference proteome.
FT CHAIN 1..97
FT /note="Sperm protein associated with the nucleus on the X
FT chromosome A"
FT /id="PRO_0000189549"
FT REGION 1..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 37..45
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
SQ SEQUENCE 97 AA; 11038 MW; 35DD0CEDF8A71376 CRC64;
MDKQSSAGGV KRSVPCDSNE ANEMMPETPT GDSDPQPAPK KMKTSESSTI LVVRYRRNFK
RTSPEELLND HARENRINPL QMEEEEFMEI MVEIPAK
