SPNXB_HUMAN
ID SPNXB_HUMAN Reviewed; 103 AA.
AC Q9NS25; A0A0G2JJ56; B2RPP2; Q32WQ7; Q5JYZ7; Q8TAD5;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2015, sequence version 2.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Sperm protein associated with the nucleus on the X chromosome B1 {ECO:0000305};
DE AltName: Full=Cancer/testis antigen 11.2 {ECO:0000305};
DE Short=CT11.2 {ECO:0000312|HGNC:HGNC:14329};
DE AltName: Full=Nuclear-associated protein SPAN-Xb {ECO:0000312|EMBL:AAF28421.1};
DE Short=SPANX-B {ECO:0000312|EMBL:AAW47348.1};
DE AltName: Full=SPANX family member B1 {ECO:0000312|HGNC:HGNC:14329};
DE AltName: Full=SPANX family member F1 {ECO:0000312|HGNC:HGNC:14329};
GN Name=SPANXB1 {ECO:0000312|HGNC:HGNC:14329};
GN Synonyms=SPANXB, SPANXB2 {ECO:0000312|HGNC:HGNC:14329},
GN SPANXF1 {ECO:0000312|HGNC:HGNC:14329};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, TISSUE SPECIFICITY,
RP VARIANT VAL-74, AND SUBCELLULAR LOCATION.
RC TISSUE=Testis;
RX PubMed=10906052; DOI=10.1093/biolreprod/63.2.469;
RA Westbrook V.A., Diekman A.B., Klotz K.L., Khole V.V., von Kap-Herr C.,
RA Golden W.L., Eddy R.L., Shows T.B., Stoler M.H., Lee C.-G.,
RA Flickinger C.J., Herr J.C.;
RT "Spermatid-specific expression of the novel X-linked gene product SPAN-X
RT localized to the nucleus of human spermatozoa.";
RL Biol. Reprod. 63:469-481(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANT VAL-74, DEVELOPMENTAL
RP STAGE, AND TISSUE SPECIFICITY.
RX PubMed=12758128; DOI=10.1016/s0378-1119(03)00497-9;
RA Zendman A.J., Zschocke J., van Kraats A.A., de Wit N.J.W., Kurpisz M.,
RA Weidle U.H., Ruiter D.J., Weiss E.H., van Muijen G.N.P.;
RT "The human SPANX multigene family: genomic organization, alignment and
RT expression in male germ cells and tumor cell lines.";
RL Gene 309:125-133(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT VAL-74.
RX PubMed=16251457; DOI=10.1101/gr.4212705;
RA Kouprina N., Pavlicek A., Noskov V.N., Solomon G., Otstot J., Isaacs W.,
RA Carpten J.D., Trent J.M., Schleutker J., Barrett J.C., Jurka J.,
RA Larionov V.;
RT "Dynamic structure of the SPANX gene cluster mapped to the prostate cancer
RT susceptibility locus HPCX at Xq27.";
RL Genome Res. 15:1477-1486(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT VAL-74.
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT VAL-74.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q9NS25; Q4LE39-3: ARID4B; NbExp=3; IntAct=EBI-17197485, EBI-11957452;
CC Q9NS25; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-17197485, EBI-741158;
CC Q9NS25; Q86XE0: SNX32; NbExp=3; IntAct=EBI-17197485, EBI-8099743;
CC Q9NS25; Q9BZL1: UBL5; NbExp=3; IntAct=EBI-17197485, EBI-607755;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10906052}. Nucleus
CC {ECO:0000269|PubMed:10906052}. Note=Associated with nuclear craters.
CC -!- TISSUE SPECIFICITY: Detected in testis and sperm.
CC {ECO:0000269|PubMed:10906052, ECO:0000269|PubMed:12758128}.
CC -!- DEVELOPMENTAL STAGE: Detected in round and elongating spermatids.
CC {ECO:0000269|PubMed:10906052, ECO:0000269|PubMed:12758128}.
CC -!- SIMILARITY: Belongs to the SPAN-X family. {ECO:0000305}.
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DR EMBL; AF098307; AAF28421.1; -; mRNA.
DR EMBL; AJ457789; CAD29838.1; -; Genomic_DNA.
DR EMBL; AJ457793; CAD29842.1; -; Genomic_DNA.
DR EMBL; AJ457796; CAD29845.1; -; mRNA.
DR EMBL; AY787057; AAW47348.1; -; Genomic_DNA.
DR EMBL; AY787058; AAW47349.1; -; Genomic_DNA.
DR EMBL; AY787059; AAW47350.1; -; Genomic_DNA.
DR EMBL; AY787060; AAW47351.1; -; Genomic_DNA.
DR EMBL; AY787061; AAW47352.1; -; Genomic_DNA.
DR EMBL; AY787062; AAW47353.1; -; Genomic_DNA.
DR EMBL; AY787063; AAW47354.1; -; Genomic_DNA.
DR EMBL; AY787064; AAW47355.1; -; Genomic_DNA.
DR EMBL; AY787065; AAW47356.1; -; Genomic_DNA.
DR EMBL; AY787066; AAW47357.1; -; Genomic_DNA.
DR EMBL; AY787067; AAW47358.1; -; Genomic_DNA.
DR EMBL; AY787068; AAW47359.1; -; Genomic_DNA.
DR EMBL; AY787069; AAW47360.1; -; Genomic_DNA.
DR EMBL; AY787070; AAW47361.1; -; Genomic_DNA.
DR EMBL; AY787071; AAW47362.1; -; Genomic_DNA.
DR EMBL; AY787072; AAW47363.1; -; Genomic_DNA.
DR EMBL; AY787073; AAW47364.1; -; Genomic_DNA.
DR EMBL; AY787074; AAW47365.1; -; Genomic_DNA.
DR EMBL; AY787075; AAW47366.1; -; Genomic_DNA.
DR EMBL; AY787076; AAW47367.1; -; Genomic_DNA.
DR EMBL; AY787077; AAW47368.1; -; Genomic_DNA.
DR EMBL; AY787078; AAW47369.1; -; Genomic_DNA.
DR EMBL; AY787079; AAW47370.1; -; Genomic_DNA.
DR EMBL; AY787080; AAW47371.1; -; Genomic_DNA.
DR EMBL; AY787081; AAW47372.1; -; Genomic_DNA.
DR EMBL; AY787082; AAW47373.1; -; Genomic_DNA.
DR EMBL; AY787083; AAW47374.1; -; Genomic_DNA.
DR EMBL; AY787090; AAW47376.1; -; Genomic_DNA.
DR EMBL; AY787092; AAW47377.1; -; Genomic_DNA.
DR EMBL; AY787127; AAW47380.1; -; Genomic_DNA.
DR EMBL; AY787130; AAW47382.1; -; Genomic_DNA.
DR EMBL; AY787632; AAW47383.1; -; Genomic_DNA.
DR EMBL; AL031078; CAI42717.1; -; Genomic_DNA.
DR EMBL; AL031078; CAI42718.1; -; Genomic_DNA.
DR EMBL; AL451048; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC034472; AAH34472.1; -; mRNA.
DR EMBL; BC137533; AAI37534.1; -; mRNA.
DR EMBL; BC137536; AAI37537.1; -; mRNA.
DR CCDS; CCDS44006.1; -.
DR RefSeq; NP_115850.2; NM_032461.3.
DR AlphaFoldDB; Q9NS25; -.
DR BioGRID; 609116; 13.
DR IntAct; Q9NS25; 7.
DR MINT; Q9NS25; -.
DR STRING; 9606.ENSP00000405202; -.
DR iPTMnet; Q9NS25; -.
DR PhosphoSitePlus; Q9NS25; -.
DR BioMuta; SPANXB1; -.
DR DMDM; 85700153; -.
DR EPD; Q9NS25; -.
DR MassIVE; Q9NS25; -.
DR MaxQB; Q9NS25; -.
DR PaxDb; Q9NS25; -.
DR PeptideAtlas; Q9NS25; -.
DR PRIDE; Q9NS25; -.
DR ProteomicsDB; 82473; -.
DR Antibodypedia; 30545; 92 antibodies from 19 providers.
DR DNASU; 728695; -.
DR Ensembl; ENST00000449283.2; ENSP00000405202.1; ENSG00000227234.2.
DR GeneID; 728695; -.
DR KEGG; hsa:728695; -.
DR MANE-Select; ENST00000449283.2; ENSP00000405202.1; NM_032461.4; NP_115850.2.
DR UCSC; uc004fbi.3; human.
DR CTD; 728695; -.
DR DisGeNET; 728695; -.
DR GeneCards; SPANXB1; -.
DR HGNC; HGNC:14329; SPANXB1.
DR HPA; ENSG00000227234; Tissue enriched (testis).
DR MIM; 300669; gene.
DR neXtProt; NX_Q9NS25; -.
DR OpenTargets; ENSG00000227234; -.
DR PharmGKB; PA37871; -.
DR VEuPathDB; HostDB:ENSG00000227234; -.
DR eggNOG; ENOG502TEHU; Eukaryota.
DR GeneTree; ENSGT00730000111796; -.
DR InParanoid; Q9NS25; -.
DR PhylomeDB; Q9NS25; -.
DR TreeFam; TF341404; -.
DR PathwayCommons; Q9NS25; -.
DR SignaLink; Q9NS25; -.
DR BioGRID-ORCS; 728695; 16 hits in 241 CRISPR screens.
DR ChiTaRS; SPANXB1; human.
DR GenomeRNAi; 728695; -.
DR Pharos; Q9NS25; Tbio.
DR PRO; PR:Q9NS25; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q9NS25; protein.
DR Bgee; ENSG00000227234; Expressed in left testis and 62 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; HDA:UniProtKB.
DR GO; GO:0007286; P:spermatid development; NAS:UniProtKB.
DR InterPro; IPR010007; SPAN-X_fam.
DR PANTHER; PTHR23425; PTHR23425; 1.
DR Pfam; PF07458; SPAN-X; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Nucleus; Reference proteome.
FT CHAIN 1..103
FT /note="Sperm protein associated with the nucleus on the X
FT chromosome B1"
FT /id="PRO_0000189550"
FT REGION 1..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 43..51
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 1..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..103
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 74
FT /note="L -> V (in dbSNP:rs878856926)"
FT /evidence="ECO:0000269|PubMed:10906052,
FT ECO:0000269|PubMed:12758128, ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:15772651, ECO:0000269|PubMed:16251457"
FT /id="VAR_021163"
SQ SEQUENCE 103 AA; 11840 MW; CABB0D7B5993266D CRC64;
MGQQSSVRRL KRSVPCESNE ANEANEANKT MPETPTGDSD PQPAPKKMKT SESSTILVVR
YRRNVKRTSP EELLNDHARE NRINPDQMEE EEFIEITTER PKK
