SPNXC_HUMAN
ID SPNXC_HUMAN Reviewed; 97 AA.
AC Q9NY87; Q32WL2; Q32WL9; Q32WM0; Q5JX88; Q8TAD1; Q9BS24;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2015, sequence version 2.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Sperm protein associated with the nucleus on the X chromosome C {ECO:0000305};
DE AltName: Full=Cancer/testis antigen 11.3;
DE Short=CT11.3 {ECO:0000312|HGNC:HGNC:14331};
DE AltName: Full=Cancer/testis-associated protein CTp11 {ECO:0000312|EMBL:CAB75344.1};
DE AltName: Full=Nuclear-associated protein SPAN-Xc;
DE Short=SPANX-C {ECO:0000312|EMBL:AAW47309.1};
DE AltName: Full=SPANX family member C;
GN Name=SPANXC;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC TISSUE=Melanoma;
RX PubMed=10626816;
RA Zendman A.J.W., Cornelissen I.M.H.A., Weidle U.H., Ruiter D.J.,
RA Van Muijen G.N.P.;
RT "CTp11, a novel member of the family of cancer-testis antigens.";
RL Cancer Res. 59:6223-6229(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], DEVELOPMENTAL STAGE, AND TISSUE
RP SPECIFICITY.
RX PubMed=12758128; DOI=10.1016/s0378-1119(03)00497-9;
RA Zendman A.J., Zschocke J., van Kraats A.A., de Wit N.J.W., Kurpisz M.,
RA Weidle U.H., Ruiter D.J., Weiss E.H., van Muijen G.N.P.;
RT "The human SPANX multigene family: genomic organization, alignment and
RT expression in male germ cells and tumor cell lines.";
RL Gene 309:125-133(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT PHE-59.
RX PubMed=16251457; DOI=10.1101/gr.4212705;
RA Kouprina N., Pavlicek A., Noskov V.N., Solomon G., Otstot J., Isaacs W.,
RA Carpten J.D., Trent J.M., Schleutker J., Barrett J.C., Jurka J.,
RA Larionov V.;
RT "Dynamic structure of the SPANX gene cluster mapped to the prostate cancer
RT susceptibility locus HPCX at Xq27.";
RL Genome Res. 15:1477-1486(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT PHE-59.
RX PubMed=17373721; DOI=10.1002/pros.20561;
RA Kouprina N., Noskov V.N., Solomon G., Otstot J., Isaacs W., Xu J.,
RA Schleutker J., Larionov V.;
RT "Mutational analysis of SPANX genes in families with X-linked prostate
RT cancer.";
RL Prostate 67:820-828(2007).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Bone marrow, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q9NY87; P42858: HTT; NbExp=3; IntAct=EBI-10316585, EBI-466029;
CC Q9NY87; Q9Y6X0: SETBP1; NbExp=3; IntAct=EBI-10316585, EBI-2548259;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10626816}. Nucleus
CC {ECO:0000269|PubMed:10626816}. Note=Associated with nuclear craters.
CC -!- TISSUE SPECIFICITY: Detected in testis, melanoma and bladder carcinoma.
CC {ECO:0000269|PubMed:10626816, ECO:0000269|PubMed:12758128}.
CC -!- DEVELOPMENTAL STAGE: Detected in round and elongating spermatids.
CC {ECO:0000269|PubMed:12758128}.
CC -!- SIMILARITY: Belongs to the SPAN-X family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJ238277; CAB75344.1; -; mRNA.
DR EMBL; AJ457790; CAD29839.1; -; Genomic_DNA.
DR EMBL; AJ457792; CAD29841.1; -; Genomic_DNA.
DR EMBL; AJ457795; CAD29844.1; -; mRNA.
DR EMBL; AY787084; AAW47309.1; -; Genomic_DNA.
DR EMBL; AY787086; AAW47310.1; -; Genomic_DNA.
DR EMBL; AY787088; AAW47312.1; -; Genomic_DNA.
DR EMBL; AY787089; AAW47313.1; -; Genomic_DNA.
DR EMBL; AY787091; AAW47314.1; -; Genomic_DNA.
DR EMBL; AY787093; AAW47315.1; -; Genomic_DNA.
DR EMBL; AY787095; AAW47317.1; -; Genomic_DNA.
DR EMBL; AY787096; AAW47318.1; -; Genomic_DNA.
DR EMBL; AY787097; AAW47319.1; -; Genomic_DNA.
DR EMBL; AY787098; AAW47320.1; -; Genomic_DNA.
DR EMBL; AY787099; AAW47321.1; -; Genomic_DNA.
DR EMBL; AY787100; AAW47322.1; -; Genomic_DNA.
DR EMBL; AY787102; AAW47324.1; -; Genomic_DNA.
DR EMBL; AY787103; AAW47325.1; -; Genomic_DNA.
DR EMBL; AY787104; AAW47326.1; -; Genomic_DNA.
DR EMBL; AY787105; AAW47327.1; -; Genomic_DNA.
DR EMBL; AY787106; AAW47328.1; -; Genomic_DNA.
DR EMBL; AY787107; AAW47329.1; -; Genomic_DNA.
DR EMBL; AY787108; AAW47330.1; -; Genomic_DNA.
DR EMBL; AY787109; AAW47331.1; -; Genomic_DNA.
DR EMBL; AY787110; AAW47332.1; -; Genomic_DNA.
DR EMBL; AY787111; AAW47333.1; -; Genomic_DNA.
DR EMBL; AY787112; AAW47334.1; -; Genomic_DNA.
DR EMBL; AY787113; AAW47335.1; -; Genomic_DNA.
DR EMBL; AY787114; AAW47336.1; -; Genomic_DNA.
DR EMBL; AY787116; AAW47338.1; -; Genomic_DNA.
DR EMBL; AY787117; AAW47339.1; -; Genomic_DNA.
DR EMBL; AY787119; AAW47341.1; -; Genomic_DNA.
DR EMBL; AY787121; AAW47343.1; -; Genomic_DNA.
DR EMBL; AY787122; AAW47344.1; -; Genomic_DNA.
DR EMBL; AY787124; AAW47346.1; -; Genomic_DNA.
DR EMBL; DQ994211; ABK19852.1; -; Genomic_DNA.
DR EMBL; DQ994213; ABK19854.1; -; Genomic_DNA.
DR EMBL; DQ994214; ABK19855.1; -; Genomic_DNA.
DR EMBL; DQ994215; ABK19856.1; -; Genomic_DNA.
DR EMBL; DQ994216; ABK19857.1; -; Genomic_DNA.
DR EMBL; DQ994217; ABK19858.1; -; Genomic_DNA.
DR EMBL; DQ994218; ABK19859.1; -; Genomic_DNA.
DR EMBL; DQ994219; ABK19860.1; -; Genomic_DNA.
DR EMBL; DQ994220; ABK19861.1; -; Genomic_DNA.
DR EMBL; DQ994222; ABK19863.1; -; Genomic_DNA.
DR EMBL; DQ994223; ABK19864.1; -; Genomic_DNA.
DR EMBL; DQ994225; ABK19866.1; -; Genomic_DNA.
DR EMBL; DQ994227; ABK19868.1; -; Genomic_DNA.
DR EMBL; DQ994228; ABK19869.1; -; Genomic_DNA.
DR EMBL; DQ994229; ABK19870.1; -; Genomic_DNA.
DR EMBL; DQ994230; ABK19871.1; -; Genomic_DNA.
DR EMBL; DQ994231; ABK19872.1; -; Genomic_DNA.
DR EMBL; DQ994232; ABK19873.1; -; Genomic_DNA.
DR EMBL; DQ994233; ABK19874.1; -; Genomic_DNA.
DR EMBL; DQ994234; ABK19875.1; -; Genomic_DNA.
DR EMBL; DQ994235; ABK19876.1; -; Genomic_DNA.
DR EMBL; DQ994238; ABK19879.1; -; Genomic_DNA.
DR EMBL; DQ994239; ABK19880.1; -; Genomic_DNA.
DR EMBL; EF101635; ABK96942.1; -; Genomic_DNA.
DR EMBL; EF101636; ABK96943.1; -; Genomic_DNA.
DR EMBL; EF101638; ABK96945.1; -; Genomic_DNA.
DR EMBL; EF101639; ABK96946.1; -; Genomic_DNA.
DR EMBL; EF101640; ABK96947.1; -; Genomic_DNA.
DR EMBL; EF101641; ABK96948.1; -; Genomic_DNA.
DR EMBL; EF101642; ABK96949.1; -; Genomic_DNA.
DR EMBL; EF101643; ABK96950.1; -; Genomic_DNA.
DR EMBL; EF101644; ABK96951.1; -; Genomic_DNA.
DR EMBL; EF101645; ABK96952.1; -; Genomic_DNA.
DR EMBL; EF101646; ABK96953.1; -; Genomic_DNA.
DR EMBL; EF101647; ABK96954.1; -; Genomic_DNA.
DR EMBL; EF101648; ABK96955.1; -; Genomic_DNA.
DR EMBL; EF101649; ABK96956.1; -; Genomic_DNA.
DR EMBL; EF101651; ABK96958.1; -; Genomic_DNA.
DR EMBL; EF101652; ABK96959.1; -; Genomic_DNA.
DR EMBL; EF101653; ABK96960.1; -; Genomic_DNA.
DR EMBL; EF101654; ABK96961.1; -; Genomic_DNA.
DR EMBL; EF101655; ABK96962.1; -; Genomic_DNA.
DR EMBL; EF101656; ABK96963.1; -; Genomic_DNA.
DR EMBL; EF101657; ABK96964.1; -; Genomic_DNA.
DR EMBL; EF101658; ABK96965.1; -; Genomic_DNA.
DR EMBL; EF101659; ABK96966.1; -; Genomic_DNA.
DR EMBL; AL109799; CAI41662.1; -; Genomic_DNA.
DR EMBL; AC234777; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC005382; AAH05382.1; -; mRNA.
DR EMBL; BC062672; AAH62672.1; -; mRNA.
DR EMBL; BC054023; AAH54023.1; -; mRNA.
DR CCDS; CCDS14673.1; -.
DR RefSeq; NP_073152.2; NM_022661.3.
DR RefSeq; XP_016855456.1; XM_016999967.1.
DR RefSeq; XP_016855457.1; XM_016999968.1.
DR AlphaFoldDB; Q9NY87; -.
DR BioGRID; 122228; 8.
DR IntAct; Q9NY87; 2.
DR STRING; 9606.ENSP00000351884; -.
DR iPTMnet; Q9NY87; -.
DR PhosphoSitePlus; Q9NY87; -.
DR BioMuta; SPANXC; -.
DR DMDM; 85700154; -.
DR MassIVE; Q9NY87; -.
DR MaxQB; Q9NY87; -.
DR PeptideAtlas; Q9NY87; -.
DR PRIDE; Q9NY87; -.
DR ProteomicsDB; 83195; -.
DR Antibodypedia; 30548; 132 antibodies from 24 providers.
DR DNASU; 64663; -.
DR Ensembl; ENST00000358993.3; ENSP00000351884.2; ENSG00000198573.7.
DR GeneID; 64663; -.
DR KEGG; hsa:64663; -.
DR MANE-Select; ENST00000358993.3; ENSP00000351884.2; NM_022661.4; NP_073152.2.
DR UCSC; uc033exl.2; human.
DR CTD; 64663; -.
DR DisGeNET; 64663; -.
DR GeneCards; SPANXC; -.
DR HGNC; HGNC:14331; SPANXC.
DR HPA; ENSG00000198573; Tissue enriched (testis).
DR MIM; 300330; gene.
DR neXtProt; NX_Q9NY87; -.
DR OpenTargets; ENSG00000198573; -.
DR PharmGKB; PA37873; -.
DR VEuPathDB; HostDB:ENSG00000198573; -.
DR eggNOG; ENOG502TEHU; Eukaryota.
DR GeneTree; ENSGT00730000111796; -.
DR HOGENOM; CLU_140435_1_0_1; -.
DR InParanoid; Q9NY87; -.
DR OMA; NEANEAM; -.
DR OrthoDB; 1820184at2759; -.
DR PhylomeDB; Q9NY87; -.
DR TreeFam; TF341404; -.
DR PathwayCommons; Q9NY87; -.
DR SignaLink; Q9NY87; -.
DR BioGRID-ORCS; 64663; 17 hits in 570 CRISPR screens.
DR BioGRID-ORCS; 728712; 58 hits in 566 CRISPR screens.
DR Pharos; Q9NY87; Tbio.
DR PRO; PR:Q9NY87; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q9NY87; protein.
DR Bgee; ENSG00000198573; Expressed in testis and 30 other tissues.
DR Genevisible; Q9NY87; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; HDA:UniProtKB.
DR InterPro; IPR010007; SPAN-X_fam.
DR PANTHER; PTHR23425; PTHR23425; 1.
DR Pfam; PF07458; SPAN-X; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Nucleus; Reference proteome.
FT CHAIN 1..97
FT /note="Sperm protein associated with the nucleus on the X
FT chromosome C"
FT /id="PRO_0000189551"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 37..45
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 22..47
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 59
FT /note="V -> F"
FT /evidence="ECO:0000269|PubMed:16251457,
FT ECO:0000269|PubMed:17373721"
FT /id="VAR_032024"
FT CONFLICT 17..32
FT /note="DSNEANEMMPETSSGY -> ESNEVNETMPETPTGD (in Ref. 1;
FT CAB75344, 2; CAD29839, 3; AAW47309/AAW47312/AAW47313/
FT AAW47314/AAW47315/AAW47317/AAW47319/AAW47320/AAW47321/
FT AAW47322/AAW47325/AAW47327/AAW47328/AAW47329/AAW47330/
FT AAW47331/AAW47333/AAW47334/AAW47335/AAW47336/AAW47338/
FT AAW47339/AAW47343/AAW47344/AAW47346, 4; ABK19854/ABK19856/
FT ABK19857/ABK19864/ABK19866/ABK19868/ABK19869/ABK19870/
FT ABK19871/ABK19872/ABK19873/ABK19879/ABK19880/ABK96948/
FT ABK96950/ABK96951/ABK96952/ABK96953/ABK96958/ABK96961/
FT ABK96963/ABK96966 and 6; AAH54023)"
FT /evidence="ECO:0000305"
FT CONFLICT 42
FT /note="L -> M (in Ref. 1; CAB75344, 2; CAD29839, 3;
FT AAW47309/AAW47312/AAW47313/AAW47314/AAW47315/AAW47317/
FT AAW47319/AAW47320/AAW47321/AAW47322/AAW47325/AAW47327/
FT AAW47328/AAW47329/AAW47330/AAW47331/AAW47333/AAW47334/
FT AAW47335/AAW47336/AAW47338/AAW47339/AAW47343/AAW47344/
FT AAW47346, 4; ABK19854/ABK19856/ABK19857/ABK19864/ABK19866/
FT ABK19868/ABK19869/ABK19870/ABK19871/ABK19872/ABK19873/
FT ABK19879/ABK19880/ABK96948/ABK96950/ABK96951/ABK96952/
FT ABK96953/ABK96958/ABK96961/ABK96963/ABK96966 and 6;
FT AAH54023)"
FT /evidence="ECO:0000305"
FT CONFLICT 68
FT /note="V -> L (in Ref. 1; CAB75344, 2; CAD29839, 3;
FT AAW47309/AAW47312/AAW47313/AAW47314/AAW47315/AAW47317/
FT AAW47319/AAW47320/AAW47321/AAW47322/AAW47325/AAW47326/
FT AAW47327/AAW47328/AAW47329/AAW47330/AAW47331/AAW47333/
FT AAW47334/AAW47335/AAW47336/AAW47338/AAW47339/AAW47343/
FT AAW47344/AAW47346, 4; ABK19854/ABK19856/ABK19857/ABK19863/
FT ABK19864/ABK19866/ABK19868/ABK19869/ABK19870/ABK19871/
FT ABK19872/ABK19873/ABK19879/ABK19880/ABK96945/ABK96947/
FT ABK96948/ABK96950/ABK96951/ABK96952/ABK96953/ABK96958/
FT ABK96961/ABK96962/ABK96963/ABK96966 and 6; AAH05382/
FT AAH54023/AAH62672)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 97 AA; 10982 MW; D253EC18FF9F8C6A CRC64;
MDKQSSAGGV KRSVPCDSNE ANEMMPETSS GYSDPQPAPK KLKTSESSTI LVVRYRRNVK
RTSPEELVND HARENRINPL QMEEEEFMEI MVEIPAK
