SPNXD_HUMAN
ID SPNXD_HUMAN Reviewed; 97 AA.
AC Q9BXN6; Q5JWI1;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Sperm protein associated with the nucleus on the X chromosome D {ECO:0000305};
DE AltName: Full=Cancer/testis antigen 11.4;
DE Short=CT11.4;
DE AltName: Full=Nuclear-associated protein SPAN-Xd;
DE Short=SPANX-D {ECO:0000312|EMBL:AAY18634.1};
DE AltName: Full=SPANX family member D {ECO:0000312|HGNC:HGNC:14332};
GN Name=SPANXD {ECO:0000312|HGNC:HGNC:14332};
GN Synonyms=SPANXE {ECO:0000312|HGNC:HGNC:14332};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Testis;
RA Westbrook V.A., Coppola M.A., Diekman A.B., Herr J.C.;
RT "The genes encoding the cancer testis associated protein SPAN-X exist as a
RT multiple gene family.";
RL Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], DEVELOPMENTAL STAGE, AND TISSUE
RP SPECIFICITY.
RX PubMed=12758128; DOI=10.1016/s0378-1119(03)00497-9;
RA Zendman A.J., Zschocke J., van Kraats A.A., de Wit N.J.W., Kurpisz M.,
RA Weidle U.H., Ruiter D.J., Weiss E.H., van Muijen G.N.P.;
RT "The human SPANX multigene family: genomic organization, alignment and
RT expression in male germ cells and tumor cell lines.";
RL Gene 309:125-133(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=16251457; DOI=10.1101/gr.4212705;
RA Kouprina N., Pavlicek A., Noskov V.N., Solomon G., Otstot J., Isaacs W.,
RA Carpten J.D., Trent J.M., Schleutker J., Barrett J.C., Jurka J.,
RA Larionov V.;
RT "Dynamic structure of the SPANX gene cluster mapped to the prostate cancer
RT susceptibility locus HPCX at Xq27.";
RL Genome Res. 15:1477-1486(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q9BXN6; P21333-2: FLNA; NbExp=3; IntAct=EBI-10301202, EBI-9641086;
CC Q9BXN6; Q9Y6X0: SETBP1; NbExp=3; IntAct=EBI-10301202, EBI-2548259;
CC Q9BXN6; Q9Y6X0-2: SETBP1; NbExp=3; IntAct=EBI-10301202, EBI-12235818;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC Note=Associated with nuclear craters. {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Detected in testis, sperm and a melanoma cell line.
CC {ECO:0000269|PubMed:12758128}.
CC -!- DEVELOPMENTAL STAGE: Detected in round and elongating spermatids.
CC {ECO:0000269|PubMed:12758128}.
CC -!- SIMILARITY: Belongs to the SPAN-X family. {ECO:0000305}.
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DR EMBL; AF312765; AAK28485.1; -; mRNA.
DR EMBL; AJ457791; CAD29840.1; -; Genomic_DNA.
DR EMBL; AY920931; AAY18634.1; -; Genomic_DNA.
DR EMBL; AY920933; AAY18636.1; -; Genomic_DNA.
DR EMBL; AY920934; AAY18637.1; -; Genomic_DNA.
DR EMBL; AY920935; AAY18638.1; -; Genomic_DNA.
DR EMBL; AY920936; AAY18639.1; -; Genomic_DNA.
DR EMBL; AY920937; AAY18640.1; -; Genomic_DNA.
DR EMBL; AY920939; AAY18642.1; -; Genomic_DNA.
DR EMBL; AY920940; AAY18643.1; -; Genomic_DNA.
DR EMBL; AY920941; AAY18644.1; -; Genomic_DNA.
DR EMBL; AY920942; AAY18645.1; -; Genomic_DNA.
DR EMBL; AY920943; AAY18646.1; -; Genomic_DNA.
DR EMBL; AY920944; AAY18647.1; -; Genomic_DNA.
DR EMBL; AY920945; AAY18648.1; -; Genomic_DNA.
DR EMBL; AY920946; AAY18649.1; -; Genomic_DNA.
DR EMBL; AY920947; AAY18650.1; -; Genomic_DNA.
DR EMBL; AY920948; AAY18651.1; -; Genomic_DNA.
DR EMBL; AY920949; AAY18652.1; -; Genomic_DNA.
DR EMBL; AY920950; AAY18653.1; -; Genomic_DNA.
DR EMBL; AY920951; AAY18654.1; -; Genomic_DNA.
DR EMBL; AY920952; AAY18655.1; -; Genomic_DNA.
DR EMBL; AY920953; AAY18656.1; -; Genomic_DNA.
DR EMBL; AY920954; AAY18657.1; -; Genomic_DNA.
DR EMBL; AY920955; AAY18658.1; -; Genomic_DNA.
DR EMBL; AY920956; AAY18659.1; -; Genomic_DNA.
DR EMBL; AY920957; AAY18660.1; -; Genomic_DNA.
DR EMBL; AY920958; AAY18661.1; -; Genomic_DNA.
DR EMBL; AY920959; AAY18662.1; -; Genomic_DNA.
DR EMBL; AY920960; AAY18663.1; -; Genomic_DNA.
DR EMBL; AY920961; AAY18664.1; -; Genomic_DNA.
DR EMBL; AY920962; AAY18665.1; -; Genomic_DNA.
DR EMBL; AY920963; AAY18666.1; -; Genomic_DNA.
DR EMBL; AY920965; AAY18668.1; -; Genomic_DNA.
DR EMBL; AY920966; AAY18669.1; -; Genomic_DNA.
DR EMBL; AY920967; AAY18670.1; -; Genomic_DNA.
DR EMBL; AY920968; AAY18671.1; -; Genomic_DNA.
DR EMBL; AY920969; AAY18672.1; -; Genomic_DNA.
DR EMBL; AY920970; AAY18673.1; -; Genomic_DNA.
DR EMBL; AY920971; AAY18674.1; -; Genomic_DNA.
DR EMBL; AY920972; AAY18675.1; -; Genomic_DNA.
DR EMBL; AY920973; AAY18676.1; -; Genomic_DNA.
DR EMBL; AY920974; AAY18677.1; -; Genomic_DNA.
DR EMBL; AY920975; AAY18678.1; -; Genomic_DNA.
DR EMBL; AY920976; AAY18679.1; -; Genomic_DNA.
DR EMBL; AY920977; AAY18680.1; -; Genomic_DNA.
DR EMBL; AY920978; AAY18681.1; -; Genomic_DNA.
DR EMBL; AY920979; AAY18682.1; -; Genomic_DNA.
DR EMBL; AY920980; AAY18683.1; -; Genomic_DNA.
DR EMBL; AY920981; AAY18684.1; -; Genomic_DNA.
DR EMBL; AY920982; AAY18685.1; -; Genomic_DNA.
DR EMBL; AY920985; AAY18688.1; -; Genomic_DNA.
DR EMBL; AY920986; AAY18689.1; -; Genomic_DNA.
DR EMBL; AY920987; AAY18690.1; -; Genomic_DNA.
DR EMBL; AL121881; CAI42368.1; -; Genomic_DNA.
DR EMBL; BC103961; AAI03962.1; -; mRNA.
DR EMBL; BC121070; AAI21071.1; -; mRNA.
DR EMBL; BC134418; AAI34419.1; -; mRNA.
DR CCDS; CCDS14675.1; -.
DR RefSeq; NP_115793.1; NM_032417.3.
DR AlphaFoldDB; Q9BXN6; -.
DR BioGRID; 122224; 4.
DR IntAct; Q9BXN6; 4.
DR MINT; Q9BXN6; -.
DR STRING; 9606.ENSP00000359546; -.
DR iPTMnet; Q9BXN6; -.
DR PhosphoSitePlus; Q9BXN6; -.
DR BioMuta; SPANXD; -.
DR DMDM; 85543355; -.
DR MassIVE; Q9BXN6; -.
DR MaxQB; Q9BXN6; -.
DR PaxDb; Q9BXN6; -.
DR PeptideAtlas; Q9BXN6; -.
DR PRIDE; Q9BXN6; -.
DR ProteomicsDB; 79471; -.
DR Antibodypedia; 63413; 65 antibodies from 12 providers.
DR DNASU; 64648; -.
DR Ensembl; ENST00000370515.3; ENSP00000359546.3; ENSG00000196406.4.
DR GeneID; 64648; -.
DR KEGG; hsa:64648; -.
DR MANE-Select; ENST00000370515.3; ENSP00000359546.3; NM_032417.4; NP_115793.1.
DR UCSC; uc004fbq.5; human.
DR CTD; 64648; -.
DR DisGeNET; 64648; -.
DR GeneCards; SPANXD; -.
DR HGNC; HGNC:14332; SPANXD.
DR HPA; ENSG00000196406; Tissue enriched (testis).
DR MIM; 300670; gene.
DR neXtProt; NX_Q9BXN6; -.
DR OpenTargets; ENSG00000196406; -.
DR PharmGKB; PA37874; -.
DR VEuPathDB; HostDB:ENSG00000196406; -.
DR eggNOG; ENOG502TEHU; Eukaryota.
DR GeneTree; ENSGT00730000111796; -.
DR HOGENOM; CLU_140435_1_0_1; -.
DR InParanoid; Q9BXN6; -.
DR OrthoDB; 1820184at2759; -.
DR PhylomeDB; Q9BXN6; -.
DR TreeFam; TF341404; -.
DR PathwayCommons; Q9BXN6; -.
DR SignaLink; Q9BXN6; -.
DR BioGRID-ORCS; 64648; 18 hits in 662 CRISPR screens.
DR GenomeRNAi; 64648; -.
DR Pharos; Q9BXN6; Tdark.
DR PRO; PR:Q9BXN6; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q9BXN6; protein.
DR Bgee; ENSG00000196406; Expressed in right testis and 18 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; HDA:UniProtKB.
DR InterPro; IPR010007; SPAN-X_fam.
DR PANTHER; PTHR23425; PTHR23425; 1.
DR Pfam; PF07458; SPAN-X; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Nucleus; Reference proteome.
FT CHAIN 1..97
FT /note="Sperm protein associated with the nucleus on the X
FT chromosome D"
FT /id="PRO_0000189552"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 37..45
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 22..46
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 68
FT /note="V -> L (in dbSNP:rs5953618)"
FT /id="VAR_034516"
SQ SEQUENCE 97 AA; 11029 MW; 33EDEC18FF9F96D1 CRC64;
MDKQSSAGGV KRSVPCDSNE ANEMMPETSS GYSDPQPAPK KLKTSESSTI LVVRYRRNFK
RTSPEELVND HARKNRINPL QMEEEEFMEI MVEIPAK
