SPO13_SCHPO
ID SPO13_SCHPO Reviewed; 138 AA.
AC C6Y4C9;
DT 24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 22-SEP-2009, sequence version 1.
DT 25-MAY-2022, entry version 63.
DE RecName: Full=Sporulation-specific protein 13;
GN Name=spo13; ORFNames=SPCC1183.12;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP FUNCTION, INDUCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH SPO2.
RX PubMed=18367542; DOI=10.1091/mbc.e08-02-0118;
RA Nakase Y., Nakamura-Kubo M., Ye Y., Hirata A., Shimoda C., Nakamura T.;
RT "Meiotic spindle pole bodies acquire the ability to assemble the spore
RT plasma membrane by sequential recruitment of sporulation-specific
RT components in fission yeast.";
RL Mol. Biol. Cell 19:2476-2487(2008).
CC -!- FUNCTION: Involved in sporulation. Plays a significant role in
CC modification of the spindle pole body prior to spore formation and is
CC required for initiating forespore membrane formation.
CC {ECO:0000269|PubMed:18367542}.
CC -!- SUBUNIT: Interacts with spo2. {ECO:0000269|PubMed:18367542}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, spindle pole body {ECO:0000269|PubMed:18367542}.
CC -!- INDUCTION: Induced during meiosis by the transcription factor mei4.
CC Protein levels rapidly increase during meiosis and then decline.
CC {ECO:0000269|PubMed:18367542}.
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DR EMBL; CU329672; CBA11516.1; -; Genomic_DNA.
DR RefSeq; XP_002788948.1; XM_002788902.2.
DR AlphaFoldDB; C6Y4C9; -.
DR SMR; C6Y4C9; -.
DR BioGRID; 1028402; 4.
DR STRING; 4896.SPCC1183.12.1; -.
DR PaxDb; C6Y4C9; -.
DR EnsemblFungi; SPCC1183.12.1; SPCC1183.12.1:pep; SPCC1183.12.
DR PomBase; SPCC1183.12; spo13.
DR VEuPathDB; FungiDB:SPCC1183.12; -.
DR HOGENOM; CLU_1856456_0_0_1; -.
DR InParanoid; C6Y4C9; -.
DR OMA; RELDYHE; -.
DR Reactome; R-SPO-5620912; Anchoring of the basal body to the plasma membrane.
DR Reactome; R-SPO-8876198; RAB GEFs exchange GTP for GDP on RABs.
DR PRO; PR:C6Y4C9; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0051286; C:cell tip; IBA:GO_Central.
DR GO; GO:0070319; C:Golgi to plasma membrane transport vesicle; IBA:GO_Central.
DR GO; GO:0035974; C:meiotic spindle pole body; IDA:PomBase.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IGI:PomBase.
DR GO; GO:0030437; P:ascospore formation; IMP:PomBase.
DR GO; GO:0032120; P:ascospore-type prospore membrane formation; IMP:PomBase.
DR GO; GO:0031322; P:ascospore-type prospore-specific spindle pole body remodeling; IMP:PomBase.
DR GO; GO:0006887; P:exocytosis; IBA:GO_Central.
DR GO; GO:1902441; P:protein localization to meiotic spindle pole body; IMP:PomBase.
DR InterPro; IPR040351; RAB3IL/RAB3IP/Sec2.
DR InterPro; IPR009449; Sec2_N.
DR PANTHER; PTHR14430; PTHR14430; 1.
DR Pfam; PF06428; Sec2p; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Cytoplasm; Cytoskeleton; Meiosis; Reference proteome;
KW Sporulation.
FT CHAIN 1..138
FT /note="Sporulation-specific protein 13"
FT /id="PRO_0000389118"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 16..104
FT /evidence="ECO:0000255"
SQ SEQUENCE 138 AA; 15862 MW; 3F037E23F0098696 CRC64;
MMSNSQISKL FSSISNKENS NENALKESTN KQLNNANTLA ITHLKEQLSR EVQRREELEG
LLEQSQKEME DLSVSLFTEA NEMVAKARQD TEVLKRELDY LRAKEKGRIG KLRSIQTAVR
TSIEARKLLS YSNESNYH
