SPO13_YEAST
ID SPO13_YEAST Reviewed; 291 AA.
AC P23624; D3DKV9;
DT 01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1991, sequence version 1.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=Meiosis-specific protein SPO13;
DE AltName: Full=Sporulation-specific protein 13;
GN Name=SPO13; OrderedLocusNames=YHR014W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX PubMed=2123556; DOI=10.1073/pnas.87.23.9406;
RA Buckingham L.E., Wang H.T., Elder R.T., McCarroll R.M., Slater M.R.,
RA Esposito R.E.;
RT "Nucleotide sequence and promoter analysis of SPO13, a meiosis-specific
RT gene of Saccharomyces cerevisiae.";
RL Proc. Natl. Acad. Sci. U.S.A. 87:9406-9410(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8091229; DOI=10.1126/science.8091229;
RA Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z.,
RA Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T.,
RA Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P., Louis E.J.,
RA Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L.,
RA St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P.,
RA Waterston R., Wilson R., Vaudin M.;
RT "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome
RT VIII.";
RL Science 265:2077-2082(1994).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [5]
RP FUNCTION.
RX PubMed=25533956; DOI=10.1038/nature14097;
RA Kim J., Ishiguro K., Nambu A., Akiyoshi B., Yokobayashi S., Kagami A.,
RA Ishiguro T., Pendas A.M., Takeda N., Sakakibara Y., Kitajima T.S.,
RA Tanno Y., Sakuno T., Watanabe Y.;
RT "Meikin is a conserved regulator of meiosis-I-specific kinetochore
RT function.";
RL Nature 517:466-471(2015).
CC -!- FUNCTION: Required for meiosis I segmentation (PubMed:2123556).
CC Probably acts as a regulator of kinetochore function during meiosis I:
CC required both for mono-orientation of kinetochores on sister
CC chromosomes and protection of centromeric cohesin from separase-
CC mediated cleavage (PubMed:25533956). {ECO:0000269|PubMed:2123556,
CC ECO:0000305|PubMed:25533956}.
CC -!- INTERACTION:
CC P23624; P32562: CDC5; NbExp=8; IntAct=EBI-17719, EBI-4440;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR EMBL; M38357; AAA35071.1; -; Genomic_DNA.
DR EMBL; U10400; AAB68941.1; -; Genomic_DNA.
DR EMBL; AY557825; AAS56151.1; -; Genomic_DNA.
DR EMBL; BK006934; DAA06703.1; -; Genomic_DNA.
DR PIR; A38426; A38426.
DR RefSeq; NP_011878.1; NM_001179144.1.
DR AlphaFoldDB; P23624; -.
DR BioGRID; 36441; 91.
DR DIP; DIP-1655N; -.
DR IntAct; P23624; 8.
DR MINT; P23624; -.
DR STRING; 4932.YHR014W; -.
DR iPTMnet; P23624; -.
DR PaxDb; P23624; -.
DR PRIDE; P23624; -.
DR EnsemblFungi; YHR014W_mRNA; YHR014W; YHR014W.
DR GeneID; 856405; -.
DR KEGG; sce:YHR014W; -.
DR SGD; S000001056; SPO13.
DR VEuPathDB; FungiDB:YHR014W; -.
DR HOGENOM; CLU_956961_0_0_1; -.
DR InParanoid; P23624; -.
DR OMA; NDSESXL; -.
DR BioCyc; YEAST:G3O-31076-MON; -.
DR PRO; PR:P23624; -.
DR Proteomes; UP000002311; Chromosome VIII.
DR RNAct; P23624; protein.
DR GO; GO:0000779; C:condensed chromosome, centromeric region; IDA:SGD.
DR GO; GO:0072687; C:meiotic spindle; IDA:SGD.
DR GO; GO:0005634; C:nucleus; IDA:SGD.
DR GO; GO:0051177; P:meiotic sister chromatid cohesion; IMP:SGD.
DR GO; GO:0045876; P:positive regulation of sister chromatid cohesion; IMP:SGD.
DR GO; GO:0071459; P:protein localization to chromosome, centromeric region; IMP:SGD.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Meiosis; Nucleus; Reference proteome; Sporulation.
FT CHAIN 1..291
FT /note="Meiosis-specific protein SPO13"
FT /id="PRO_0000072134"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 116..143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 271..291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 3..6
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 10..27
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 126..143
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 291 AA; 33295 MW; 3E277368AF234298 CRC64;
MAPRKRFRLL ELGSPTHSKR KVQKPLQEKT PNLRVSPLAF KIGKEIKNKE IRKTKKTESE
NIFNSKHVDL RLESPHPGLN FVSDAQQYSK AGDVRYLKNK SSNTLKNERQ TIERPSFDNS
LRFEDIEQPP KSTSTPVLSQ SSQINVEREA PMFPVPYYIA PSPMYNFSPY QNFVGNPTFL
TPSHNPNLNY AIPIQRPELL YPNVNVYDSP LFKKTRLPHQ TKSLDKEKNY QYLPIYPVSI
SNNGDFVGQE TPRAAPKLSK KRLSNTLDVN CSDYESSGQN ATYNDSESSL N
