ID   SPO16_BOVIN             Reviewed;         181 AA.
AC   Q2TA05;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Protein SPO16 homolog {ECO:0000250|UniProtKB:Q3KQP7};
DE   AltName: Full=Synaptonemal complex reinforcing element {ECO:0000250|UniProtKB:Q3KQP7};
GN   Name=SPO16 {ECO:0000250|UniProtKB:Q3KQP7};
GN   Synonyms=SCRE {ECO:0000250|UniProtKB:Q3KQP7};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a key role in reinforcing the integrity of the central
CC       element of the synaptonemal complex (SC) thereby stabilizing SC,
CC       ensuring progression of meiotic prophase I in male and female germ
CC       cells (By similarity). Promotes homologous recombination and crossing-
CC       over in meiotic prophase I via its association with SHOC1 (By
CC       similarity). Required for the localization of TEX11 and MSH4 to
CC       recombination intermediates (By similarity).
CC       {ECO:0000250|UniProtKB:Q3KQP7}.
CC   -!- SUBUNIT: Homooligomer (By similarity). Interacts with SHOC1, SYCP1 and
CC       SYCE3 (By similarity). {ECO:0000250|UniProtKB:Q3KQP7}.
CC   -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000250|UniProtKB:Q3KQP7}.
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DR   EMBL; BC111182; AAI11183.1; -; mRNA.
DR   RefSeq; NP_001033113.1; NM_001038024.1.
DR   RefSeq; XP_005204319.1; XM_005204262.3.
DR   RefSeq; XP_005204320.1; XM_005204263.3.
DR   AlphaFoldDB; Q2TA05; -.
DR   SMR; Q2TA05; -.
DR   STRING; 9913.ENSBTAP00000040067; -.
DR   PaxDb; Q2TA05; -.
DR   PRIDE; Q2TA05; -.
DR   Ensembl; ENSBTAT00000040290; ENSBTAP00000040067; ENSBTAG00000027936.
DR   GeneID; 504212; -.
DR   KEGG; bta:504212; -.
DR   CTD; 123635407; -.
DR   VEuPathDB; HostDB:ENSBTAG00000027936; -.
DR   VGNC; VGNC:52708; C3H1orf146.
DR   eggNOG; ENOG502S1KQ; Eukaryota.
DR   GeneTree; ENSGT00390000008285; -.
DR   HOGENOM; CLU_097019_0_0_1; -.
DR   InParanoid; Q2TA05; -.
DR   OMA; SPVWKML; -.
DR   OrthoDB; 1325546at2759; -.
DR   TreeFam; TF333385; -.
DR   Proteomes; UP000009136; Chromosome 3.
DR   Bgee; ENSBTAG00000027936; Expressed in oocyte and 64 other tissues.
DR   GO; GO:0005694; C:chromosome; ISS:UniProtKB.
DR   GO; GO:0007131; P:reciprocal meiotic recombination; ISS:UniProtKB.
DR   GO; GO:0007130; P:synaptonemal complex assembly; ISS:UniProtKB.
DR   InterPro; IPR027857; SCRE.
DR   PANTHER; PTHR31408; PTHR31408; 1.
DR   Pfam; PF15162; SCRE; 1.
PE   2: Evidence at transcript level;
KW   Chromosome; Meiosis; Reference proteome.
FT   CHAIN           1..181
FT                   /note="Protein SPO16 homolog"
FT                   /id="PRO_0000299019"
SQ   SEQUENCE   181 AA;  20622 MW;  D775A5BC3FB6E2B5 CRC64;
     MAESDGKEKI KWTTTIIISS SLKSYEVAAA LENRSHKVRY SDSVENGSII FSLSGVAFLL
     MDARECFMSA EETFLAKIEK FINIHQNSFL VLFAALHGPE EWKLMFRIQQ RFLGSNLRIL
     PVHNTVNAIN LMCTIAKITS KSYIDSICYR MITTKAYIIE QSPVWKTLQK IKLSSDTFNP
     N