ID   SPO16_HUMAN             Reviewed;         180 AA.
AC   Q5VVC0; Q5VVC4;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Protein SPO16 homolog {ECO:0000250|UniProtKB:Q3KQP7};
DE   AltName: Full=Synaptonemal complex reinforcing element {ECO:0000250|UniProtKB:Q3KQP7};
GN   Name=SPO16 {ECO:0000250|UniProtKB:Q3KQP7};
GN   Synonyms=C1orf146, SCRE {ECO:0000250|UniProtKB:Q3KQP7};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Plays a key role in reinforcing the integrity of the central
CC       element of the synaptonemal complex (SC) thereby stabilizing SC,
CC       ensuring progression of meiotic prophase I in male and female germ
CC       cells (By similarity). Promotes homologous recombination and crossing-
CC       over in meiotic prophase I via its association with SHOC1 (By
CC       similarity). Required for the localization of TEX11 and MSH4 to
CC       recombination intermediates (By similarity).
CC       {ECO:0000250|UniProtKB:Q3KQP7}.
CC   -!- SUBUNIT: Homooligomer (By similarity). Interacts with SHOC, SYCP1 and
CC       SYCE3 (By similarity). {ECO:0000250|UniProtKB:Q3KQP7}.
CC   -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000250|UniProtKB:Q3KQP7}.
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DR   EMBL; AL451010; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC130499; AAI30500.1; -; mRNA.
DR   CCDS; CCDS30772.1; -.
DR   RefSeq; NP_001012425.1; NM_001012425.1.
DR   RefSeq; XP_011539749.1; XM_011541447.2.
DR   AlphaFoldDB; Q5VVC0; -.
DR   SMR; Q5VVC0; -.
DR   BioGRID; 132792; 7.
DR   STRING; 9606.ENSP00000359401; -.
DR   iPTMnet; Q5VVC0; -.
DR   PhosphoSitePlus; Q5VVC0; -.
DR   BioMuta; C1orf146; -.
DR   jPOST; Q5VVC0; -.
DR   PaxDb; Q5VVC0; -.
DR   PRIDE; Q5VVC0; -.
DR   ProteomicsDB; 65455; -.
DR   Antibodypedia; 53285; 50 antibodies from 11 providers.
DR   DNASU; 388649; -.
DR   Ensembl; ENST00000370375.8; ENSP00000359401.3; ENSG00000203910.9.
DR   GeneID; 388649; -.
DR   KEGG; hsa:388649; -.
DR   MANE-Select; ENST00000370375.8; ENSP00000359401.3; NM_001012425.2; NP_001012425.1.
DR   UCSC; uc001doq.4; human.
DR   CTD; 388649; -.
DR   GeneCards; C1orf146; -.
DR   HGNC; HGNC:24032; C1orf146.
DR   HPA; ENSG00000203910; Group enriched (retina, testis).
DR   MIM; 618968; gene.
DR   neXtProt; NX_Q5VVC0; -.
DR   PharmGKB; PA142672463; -.
DR   VEuPathDB; HostDB:ENSG00000203910; -.
DR   eggNOG; ENOG502S1KQ; Eukaryota.
DR   GeneTree; ENSGT00390000008285; -.
DR   HOGENOM; CLU_097019_0_0_1; -.
DR   InParanoid; Q5VVC0; -.
DR   OMA; SPVWKML; -.
DR   OrthoDB; 1325546at2759; -.
DR   PhylomeDB; Q5VVC0; -.
DR   TreeFam; TF333385; -.
DR   PathwayCommons; Q5VVC0; -.
DR   BioGRID-ORCS; 388649; 17 hits in 1026 CRISPR screens.
DR   ChiTaRS; C1orf146; human.
DR   GenomeRNAi; 388649; -.
DR   Pharos; Q5VVC0; Tdark.
DR   PRO; PR:Q5VVC0; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; Q5VVC0; protein.
DR   Bgee; ENSG00000203910; Expressed in right testis and 80 other tissues.
DR   ExpressionAtlas; Q5VVC0; baseline and differential.
DR   GO; GO:0005694; C:chromosome; ISS:UniProtKB.
DR   GO; GO:0007131; P:reciprocal meiotic recombination; ISS:UniProtKB.
DR   GO; GO:0007130; P:synaptonemal complex assembly; ISS:UniProtKB.
DR   InterPro; IPR027857; SCRE.
DR   PANTHER; PTHR31408; PTHR31408; 1.
DR   Pfam; PF15162; SCRE; 1.
PE   2: Evidence at transcript level;
KW   Chromosome; Meiosis; Reference proteome.
FT   CHAIN           1..180
FT                   /note="Protein SPO16 homolog"
FT                   /id="PRO_0000299020"
SQ   SEQUENCE   180 AA;  20418 MW;  5A3F31E07B9CA7A0 CRC64;
     MAESGKEKIK WTTTIIISSS LKSYEVATAL ENRSHKVRYS DSVENGSIIF SLSGVAFLLM
     DTKECLLSTE EIFLAKIEKF INIHQNSFLV LSAALHGPEE WKLMFRIQQR FLGCNLRILP
     VHNTVNAINL MCTIAKTTSK PYIDSICYRM ITAKAYIIEQ SPVWKTLQKI KLNSDSVNPN