SPO22_YEAST
ID SPO22_YEAST Reviewed; 975 AA.
AC P40511; D6VVL1;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2005, sequence version 2.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Sporulation-specific protein 22;
GN Name=SPO22; OrderedLocusNames=YIL073C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169870;
RA Churcher C.M., Bowman S., Badcock K., Bankier A.T., Brown D.,
RA Chillingworth T., Connor R., Devlin K., Gentles S., Hamlin N., Harris D.E.,
RA Horsnell T., Hunt S., Jagels K., Jones M., Lye G., Moule S., Odell C.,
RA Pearson D., Rajandream M.A., Rice P., Rowley N., Skelton J., Smith V.,
RA Walsh S.V., Whitehead S., Barrell B.G.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome IX.";
RL Nature 387:84-87(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP FUNCTION.
RX PubMed=11101837; DOI=10.1038/82539;
RA Primig M., Williams R.M., Winzeler E.A., Tevzadze G.G., Conway A.R.,
RA Hwang S.Y., Davis R.W., Esposito R.E.;
RT "The core meiotic transcriptome in budding yeasts.";
RL Nat. Genet. 26:415-423(2000).
RN [4]
RP FUNCTION.
RX PubMed=11470404; DOI=10.1016/s0960-9822(01)00274-3;
RA Rabitsch K.P., Toth A., Galova M., Schleiffer A., Schaffner G., Aigner E.,
RA Rupp C., Penkner A.M., Moreno-Borchart A.C., Primig M., Esposito R.E.,
RA Klein F., Knop M., Nasmyth K.;
RT "A screen for genes required for meiosis and spore formation based on
RT whole-genome expression.";
RL Curr. Biol. 11:1001-1009(2001).
RN [5]
RP IDENTIFICATION OF PROBABLE INITIATION SITE.
RX PubMed=12775844; DOI=10.1126/science.1084337;
RA Cliften P.F., Sudarsanam P., Desikan A., Fulton L., Fulton B., Majors J.,
RA Waterston R., Cohen B.A., Johnston M.;
RT "Finding functional features in Saccharomyces genomes by phylogenetic
RT footprinting.";
RL Science 301:71-76(2003).
CC -!- FUNCTION: Involved in chromosome segregation during sporulation.
CC {ECO:0000269|PubMed:11101837, ECO:0000269|PubMed:11470404}.
CC -!- SIMILARITY: Belongs to the SPO22 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA86097.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; Z37997; CAA86097.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BK006942; DAA08477.1; -; Genomic_DNA.
DR PIR; S48371; S48371.
DR RefSeq; NP_012192.2; NM_001179423.1.
DR AlphaFoldDB; P40511; -.
DR BioGRID; 34919; 103.
DR ComplexPortal; CPX-1386; Synapsis initiation complex.
DR ComplexPortal; CPX-5442; ZZS complex.
DR IntAct; P40511; 1.
DR STRING; 4932.YIL073C; -.
DR PaxDb; P40511; -.
DR PRIDE; P40511; -.
DR EnsemblFungi; YIL073C_mRNA; YIL073C; YIL073C.
DR GeneID; 854737; -.
DR KEGG; sce:YIL073C; -.
DR SGD; S000001335; SPO22.
DR VEuPathDB; FungiDB:YIL073C; -.
DR eggNOG; KOG4814; Eukaryota.
DR HOGENOM; CLU_308367_0_0_1; -.
DR InParanoid; P40511; -.
DR OMA; EIEWFAS; -.
DR BioCyc; YEAST:MON3O-290031; -.
DR PRO; PR:P40511; -.
DR Proteomes; UP000002311; Chromosome IX.
DR RNAct; P40511; protein.
DR GO; GO:0000794; C:condensed nuclear chromosome; IC:ComplexPortal.
DR GO; GO:0005634; C:nucleus; HDA:SGD.
DR GO; GO:0106069; C:synapsis initiation complex; IC:ComplexPortal.
DR GO; GO:0007129; P:homologous chromosome pairing at meiosis; IC:ComplexPortal.
DR GO; GO:0035825; P:homologous recombination; IC:ComplexPortal.
DR GO; GO:0033235; P:positive regulation of protein sumoylation; IMP:SGD.
DR GO; GO:0016925; P:protein sumoylation; IC:ComplexPortal.
DR GO; GO:0007131; P:reciprocal meiotic recombination; IC:ComplexPortal.
DR GO; GO:0090173; P:regulation of synaptonemal complex assembly; IMP:SGD.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR InterPro; IPR039057; Spo22.
DR InterPro; IPR013940; Spo22/ZIP4/TEX11.
DR PANTHER; PTHR40375; PTHR40375; 1.
DR Pfam; PF08631; SPO22; 1.
PE 3: Inferred from homology;
KW Meiosis; Reference proteome; Sporulation.
FT CHAIN 1..975
FT /note="Sporulation-specific protein 22"
FT /id="PRO_0000072137"
SQ SEQUENCE 975 AA; 112434 MW; 084720F5C64E2114 CRC64;
MSDHNVNSTF RKTLVELCET ATWITSQVYA AKNLEKNDLI TVDNKISALY PIAEKYDRSF
RTTTVILDEE LILKLENAAS SLWNSLTIAM KAEKASDKYF NEVFCKCKIF ATKLLSIHEA
LFRTNTNLLR NFKCYISSFK SASEYRFDDL ITNTQQHSEK YLQIINENVE SFSNEEKTEF
KKLTFEFYLV NFQLYLSEND LDTANIYTAK VNITDNSKYM DADLLIELCR MIYNSTVMLK
EINNPETQLV DVNIISFLKD VEKYLELPVE NLKSHTDYSN LKYSVLIFMA NCLVEGHPQA
SELEQCDHYL SLLQNEYPNK VDPFILAINL TKRRNIVNPA ETIEEILMRM IMSVDVISNF
QAVIASINDL SKMNTKFSIV CLDYLLINKL NSKNDSKFLG KAICSRFLIT TQSKTMNDSE
IAESLENFST QMERIVSEPL TKHAISCIIT LLWNTGKKLE KMEKYVVSIR FYKLALKDII
SQNYSDRGKI QRALQVVYNK IEDYSNTVRV YQDMDEVDRQ SPLCQLLMLQ SFLADDKTEE
ALTCLQKIKS SEDEKSTDAL ILAVAECKRK TDLSVQGLLM IFDKLQSKSN SQTISSTSSS
QTLSILRYTL QMIVKVSEEE PLETFINYLP TVQKLLQKAV EFLKTVKLLN QLPPDVEKEA
IYQQSVAVNE IEWFASFSYN VAVKCLVDQS CESISEFPQY CIQFIDLIPV QDFTFPKMYH
FTYWRFKATI LQLIIAKEKA KQDQHQKDWD IYEKSEELVN SINVMKKSSE FKDGSSLEDR
NTLHECFLEA LTIHLESALM MPDQTRILDI LKKTELYQDS RVDALLIDIS SNMEDLPKGV
LIEILETVLK RNMGPEVKER ELCSWLRILL ENAINLNHEV ELRILDRVLK ILNINQSSLQ
DTDGVLQTEL ETIATYCWNI GVNYIIKDNK SNGIVWCKHS MGFANMVNEG LQEQLYSLWE
SLASSANIDI NSIAK
