ID   SPO23_YEAST             Reviewed;         523 AA.
AC   P33757; D6VQP6;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=Sporulation protein 23;
GN   Name=SPO23; OrderedLocusNames=YBR250W; ORFNames=YBR1702;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=8256522; DOI=10.1002/yea.320091014;
RA   Doignon F., Biteau N., Aigle M., Crouzet M.;
RT   "The complete sequence of a 6794 bp segment located on the right arm of
RT   chromosome II of Saccharomyces cerevisiae. Finding of a putative dUTPase in
RT   a yeast.";
RL   Yeast 9:1131-1137(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=7813418; DOI=10.1002/j.1460-2075.1994.tb06923.x;
RA   Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C.,
RA   Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M.,
RA   Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M.,
RA   Cziepluch C., Demolis N., Delaveau T., Doignon F., Domdey H.,
RA   Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D.,
RA   Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N.,
RA   Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J.,
RA   Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C.,
RA   Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P.,
RA   Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y.,
RA   Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F.,
RA   Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E.,
RA   Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M.,
RA   Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B.,
RA   Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L.,
RA   Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M.,
RA   Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S.,
RA   Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K.,
RA   Mewes H.-W., Kleine K.;
RT   "Complete DNA sequence of yeast chromosome II.";
RL   EMBO J. 13:5795-5809(1994).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [4]
RP   FUNCTION.
RX   PubMed=15755922; DOI=10.1128/ec.4.3.604-614.2005;
RA   Gardocki M.E., Bakewell M., Kamath D., Robinson K., Borovicka K.,
RA   Lopes J.M.;
RT   "Genomic analysis of PIS1 gene expression.";
RL   Eukaryot. Cell 4:604-614(2005).
RN   [5]
RP   INTERACTION WITH SPO1, AND DISRUPTION PHENOTYPE.
RX   PubMed=17179081; DOI=10.1534/genetics.106.069252;
RA   Tevzadze G.G., Pierce J.V., Esposito R.E.;
RT   "Genetic evidence for a SPO1-dependent signaling pathway controlling
RT   meiotic progression in yeast.";
RL   Genetics 175:1213-1227(2007).
CC   -!- FUNCTION: Regulates expression of PIS1. {ECO:0000269|PubMed:15755922}.
CC   -!- SUBUNIT: Interacts with SPO1 in meiosis. {ECO:0000269|PubMed:17179081}.
CC   -!- DISRUPTION PHENOTYPE: Has a moderate sporulation defect.
CC       {ECO:0000269|PubMed:17179081}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L20296; AAA65608.1; -; Genomic_DNA.
DR   EMBL; Z36119; CAA85213.1; -; Genomic_DNA.
DR   EMBL; BK006936; DAA07366.1; -; Genomic_DNA.
DR   PIR; S38186; S38186.
DR   RefSeq; NP_009809.1; NM_001178598.1.
DR   AlphaFoldDB; P33757; -.
DR   BioGRID; 32945; 63.
DR   DIP; DIP-1651N; -.
DR   IntAct; P33757; 5.
DR   MINT; P33757; -.
DR   STRING; 4932.YBR250W; -.
DR   PaxDb; P33757; -.
DR   PRIDE; P33757; -.
DR   EnsemblFungi; YBR250W_mRNA; YBR250W; YBR250W.
DR   GeneID; 852552; -.
DR   KEGG; sce:YBR250W; -.
DR   SGD; S000000454; SPO23.
DR   VEuPathDB; FungiDB:YBR250W; -.
DR   eggNOG; ENOG502S0PG; Eukaryota.
DR   HOGENOM; CLU_038191_0_0_1; -.
DR   InParanoid; P33757; -.
DR   OMA; TTIMRIP; -.
DR   BioCyc; YEAST:G3O-29176-MON; -.
DR   PRO; PR:P33757; -.
DR   Proteomes; UP000002311; Chromosome II.
DR   RNAct; P33757; protein.
DR   GO; GO:0051321; P:meiotic cell cycle; IMP:SGD.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.640; -; 1.
DR   InterPro; IPR014752; Arrestin-like_C.
DR   InterPro; IPR011021; Arrestin-like_N.
DR   Pfam; PF00339; Arrestin_N; 1.
PE   1: Evidence at protein level;
KW   Meiosis; Reference proteome; Sporulation.
FT   CHAIN           1..523
FT                   /note="Sporulation protein 23"
FT                   /id="PRO_0000202524"
SQ   SEQUENCE   523 AA;  59919 MW;  429BCF463A14E544 CRC64;
     MLFSSSSSSL NSEVSQVFSE NISSRSTTLT ESSTQSEIRQ HFGNEDFSGE LPKKLIQLKK
     LKNGGTTIKK AKEDLEYCYD SLRLYENPYV TSSVDKKCGY SIELYLDNKY KTLMFSDLQL
     NADYPLYYDS SLDNISTNVE RERATPLQIK GKIRINIDRE DQALLITSHS ISLKCFTKEY
     ACFVNSETSK NSYSDKIIKE LNHTEFFESS TYPKQQLRVI HHSLNDKKIL LTKGTYDYPF
     TFTLQANTFP ASFSSFFGKT HFRIESLTTI MRIPSKPKNL LKFLKNESFT DKIILTEEIK
     VKRVLPSTSM LKFETFQLRS YNTASEIVVS VIGNSKLIEI GMPFQMILSI TKTDSSIELQ
     EASLAVAQRM AIPSIDLKTK KILREPYIKK SEYLLRTVES QSFDSDKTIF GFCFDDVVIP
     TYADGLPSWF KTFYCEPSSF YPNHAALKVT HLLLFRITYS RNELVEGLEM KKNYRITVNF
     PILVGDSDIS TSSLLPKYEK FENISDLQDE PPLYSMVAGE NSL