ID   SPO2_SCHPO              Reviewed;         133 AA.
AC   C6Y4C2;
DT   24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   22-SEP-2009, sequence version 1.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=Sporulation-specific protein 2;
GN   Name=spo2; ORFNames=SPBC16C6.14;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   FUNCTION, INDUCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH SPO13 AND
RP   SPO15.
RX   PubMed=18367542; DOI=10.1091/mbc.e08-02-0118;
RA   Nakase Y., Nakamura-Kubo M., Ye Y., Hirata A., Shimoda C., Nakamura T.;
RT   "Meiotic spindle pole bodies acquire the ability to assemble the spore
RT   plasma membrane by sequential recruitment of sporulation-specific
RT   components in fission yeast.";
RL   Mol. Biol. Cell 19:2476-2487(2008).
CC   -!- FUNCTION: Involved in sporulation. Plays a significant role in
CC       modification of the spindle pole body prior to spore formation and is
CC       required for initiating forespore membrane formation. Assists in the
CC       localization of spo13 to the outer surface of the SPB.
CC       {ECO:0000269|PubMed:18367542}.
CC   -!- SUBUNIT: Interacts with spo13 and spo15. {ECO:0000269|PubMed:18367542}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, spindle pole body {ECO:0000269|PubMed:18367542}.
CC   -!- INDUCTION: Induced during meiosis by the transcription factor mei4.
CC       Protein levels rapidly increase during meiosis and then decline.
CC       {ECO:0000269|PubMed:18367542}.
CC   -!- MISCELLANEOUS: The sequence is 100 percent identical to the C-terminus
CC       of vps13b.
CC   -!- SIMILARITY: Belongs to the VPS13 family. {ECO:0000305}.
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DR   EMBL; CU329671; CBA11512.1; -; Genomic_DNA.
DR   RefSeq; XP_002788944.1; XM_002788898.2.
DR   AlphaFoldDB; C6Y4C2; -.
DR   SMR; C6Y4C2; -.
DR   BioGRID; 1028587; 3.
DR   STRING; 4896.SPBC16C6.14.1; -.
DR   PaxDb; C6Y4C2; -.
DR   EnsemblFungi; SPBC16C6.14.1; SPBC16C6.14.1:pep; SPBC16C6.14.
DR   PomBase; SPBC16C6.14; spo2.
DR   VEuPathDB; FungiDB:SPBC16C6.14; -.
DR   eggNOG; KOG1809; Eukaryota.
DR   HOGENOM; CLU_1907899_0_0_1; -.
DR   OMA; ERSCIEN; -.
DR   PRO; PR:C6Y4C2; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0035974; C:meiotic spindle pole body; IDA:PomBase.
DR   GO; GO:0030437; P:ascospore formation; IMP:PomBase.
DR   GO; GO:0031322; P:ascospore-type prospore-specific spindle pole body remodeling; IMP:PomBase.
PE   1: Evidence at protein level;
KW   Cytoplasm; Cytoskeleton; Meiosis; Reference proteome; Sporulation.
FT   CHAIN           1..133
FT                   /note="Sporulation-specific protein 2"
FT                   /id="PRO_0000389117"
SQ   SEQUENCE   133 AA;  15577 MW;  4FE8BF4809208560 CRC64;
     MSITMSDSSA YGEELMRERF EHLLKAYEKM ALMVAEQEEF NAKIEDMALK LLSEKYDNEA
     YQAELFYRLS NCVEKVLHNK ISITDLKTEY EEILEQTLKK ECKAYERSCI ENVKLKKRTE
     QATAYYASSS SEP