SPO5_SCHPO
ID SPO5_SCHPO Reviewed; 567 AA.
AC Q2L4W6; O94381;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 1.
DT 25-MAY-2022, entry version 89.
DE RecName: Full=Sporulation-specific protein 5;
DE AltName: Full=Meiotic RNA-binding protein 1;
DE AltName: Full=Meiotically up-regulated gene 12 protein;
GN Name=spo5; Synonyms=mrb1, mug12; ORFNames=SPBC29A10.02, SPBC365.18;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=16896214; DOI=10.1128/ec.00099-06;
RA Kasama T., Shigehisa A., Hirata A., Saito T.T., Tougan T., Okuzaki D.,
RA Nojima H.;
RT "Spo5/Mug12, a putative meiosis-specific RNA-binding protein, is essential
RT for meiotic progression and forms Mei2 dot-like nuclear foci.";
RL Eukaryot. Cell 5:1301-1313(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [3]
RP FUNCTION IN SPORULATION.
RX PubMed=16303567; DOI=10.1016/j.cub.2005.10.038;
RA Martin-Castellanos C., Blanco M., Rozalen A.E., Perez-Hidalgo L.,
RA Garcia A.I., Conde F., Mata J., Ellermeier C., Davis L., San-Segundo P.,
RA Smith G.R., Moreno S.;
RT "A large-scale screen in S. pombe identifies seven novel genes required for
RT critical meiotic events.";
RL Curr. Biol. 15:2056-2062(2005).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: RNA-binding protein which plays a role in sporulation.
CC Regulates the progression of meiosis I and may function in the vicinity
CC of the Mei2 dot. {ECO:0000269|PubMed:16303567,
CC ECO:0000269|PubMed:16896214}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372,
CC ECO:0000269|PubMed:16896214}.
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DR EMBL; AB248101; BAE78593.1; -; Genomic_DNA.
DR EMBL; CU329671; CAB44770.1; -; Genomic_DNA.
DR PIR; T40057; T40057.
DR RefSeq; NP_596047.1; NM_001021957.2.
DR AlphaFoldDB; Q2L4W6; -.
DR SMR; Q2L4W6; -.
DR BioGRID; 277163; 11.
DR STRING; 4896.SPBC29A10.02.1; -.
DR PaxDb; Q2L4W6; -.
DR EnsemblFungi; SPBC29A10.02.1; SPBC29A10.02.1:pep; SPBC29A10.02.
DR GeneID; 2540637; -.
DR KEGG; spo:SPBC29A10.02; -.
DR PomBase; SPBC29A10.02; spo5.
DR VEuPathDB; FungiDB:SPBC29A10.02; -.
DR eggNOG; KOG4733; Eukaryota.
DR HOGENOM; CLU_447703_0_0_1; -.
DR InParanoid; Q2L4W6; -.
DR OMA; CISAMTL; -.
DR PhylomeDB; Q2L4W6; -.
DR PRO; PR:Q2L4W6; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005737; C:cytoplasm; IDA:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; IDA:PomBase.
DR GO; GO:1990904; C:ribonucleoprotein complex; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; ISM:PomBase.
DR GO; GO:0030437; P:ascospore formation; IMP:PomBase.
DR GO; GO:0031322; P:ascospore-type prospore-specific spindle pole body remodeling; IMP:PomBase.
DR GO; GO:0007127; P:meiosis I; IMP:PomBase.
DR GO; GO:0007135; P:meiosis II; IMP:PomBase.
DR GO; GO:0071763; P:nuclear membrane organization; IMP:PomBase.
DR GO; GO:0034504; P:protein localization to nucleus; IMP:PomBase.
DR Gene3D; 3.30.70.330; -; 2.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR Pfam; PF00076; RRM_1; 2.
DR SMART; SM00360; RRM; 2.
DR SUPFAM; SSF54928; SSF54928; 2.
DR PROSITE; PS50102; RRM; 2.
PE 1: Evidence at protein level;
KW Cytoplasm; Meiosis; Reference proteome; Repeat; RNA-binding; Sporulation.
FT CHAIN 1..567
FT /note="Sporulation-specific protein 5"
FT /id="PRO_0000300506"
FT DOMAIN 296..380
FT /note="RRM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 384..462
FT /note="RRM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 52..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 567 AA; 62945 MW; 9176EF6D8BC7BBBF CRC64;
MNGIITPQKQ KQLMSSPSRD PLSTTELSTP TSQTTVDVND TKKSEGLDST IILLTPGTSP
NATPGSSELG LSKKPNSIKN NTYSTAAQAA YLNRRAADQS TVMTTDPISY ANNNINNGTL
PQQNAYYANS YYPSYYAQSQ AISNNRPGVS GFRPAFNSVA PCYGSQWQTH QSVHPYHVNN
THQYLKPYVQ NVYPQMPSLN QPGLHIVNQP TYLAPVPSAT VPTNSVSLSM PSFSQGQKNI
PAAINQEMSV GTTKENTNYL SQLVGLHPAI PPAIPSMFPM SHDNKKSNME STSRTRNVYI
RGLPPNTSDE NLLLYTNRFG KVSSSKAIID METNLCKGYG FACFEEEKSA LICISAMTLC
GYQCSFAKES FSARLQSLQD TESTNLYISN LPLHWNESDI STLFKPSKII SNRVLRDSKE
QSRGVGFARM QDRKTAEDII NKFNNFVLDP ALPPLQIRFA DSTDQKKFKG QTQKRRLWRA
REYSVLTKGM TANNAFSKVE EFANNSMPSK VGMYVPLESN TVYQHSPTYD TYGWQSMYPS
YSVYPSNYEN SRSTTPYHAH PATSAAN
